ADOL 125mg Rectal Suppositories

What is ADOL 125mg

ADOL 125mg Rectal Suppository is a pediatric formulation of Paracetamol designed for rectal administration. It is used primarily for its antipyretic (fever-reducing) and analgesic (pain-relieving) properties in children. Each suppository contains 125mg of Paracetamol, making it suitable for young children who may have difficulty swallowing oral medications or are vomiting.

• Pharmaceutical Form: Rectal suppository
• Packaging: 10 suppositories (2 blisters of 5 each)
• Active Ingredient: Paracetamol 125mg
• Therapeutic Class: Analgesic and antipyretic

This rectal form is an effective alternative for managing pain and fever in pediatric patients, particularly during episodes of nausea, vomiting, or other gastrointestinal disturbances. It is commonly used in pediatric outpatient settings or at home for acute conditions like viral fever, teething, or post-vaccination discomfort.

How to use ADOL 125mg

Administering ADOL suppositories properly ensures optimal absorption and effectiveness. This dosage form is especially helpful when oral intake is not feasible due to vomiting or difficulty swallowing.

• Step 1: Wash your hands with soap and water before handling the suppository.
• Step 2: Remove the suppository from its blister packaging gently to avoid breaking it.
• Step 3: Have the child lie on their side with one leg bent towards the chest.
• Step 4: Gently insert the suppository into the rectum, pointed end first, pushing it in about 2–3 cm (for children).
• Step 5: Hold the buttocks together for a few seconds to prevent expulsion. Let the child lie still for 10–15 minutes.
• Step 6: Wash your hands again after administration.

Important Notes:

• Use only as directed by your pediatrician.
• Do not exceed the recommended dose or frequency.
• If the suppository is too soft, refrigerate it briefly before use.
• Avoid using suppositories if there are signs of rectal irritation or bleeding.

Mode of Action ADOL 125mg

ADOL 125mg contains Paracetamol, a widely used analgesic and antipyretic agent. Although its exact mechanism of action is not fully understood, Paracetamol is believed to exert its effects through several physiological pathways:

• Centrally Acting Analgesic: Paracetamol primarily works in the central nervous system (CNS). It inhibits the enzyme cyclooxygenase (COX), particularly COX-3, which is involved in the synthesis of prostaglandins. Prostaglandins are substances that mediate pain and inflammation. By reducing prostaglandin production in the brain, Paracetamol lowers the sensation of pain.
• Antipyretic Action: Paracetamol lowers fever by acting on the hypothalamic heat-regulating center. It helps to dissipate body heat through vasodilation and increased peripheral blood flow, leading to a reduction in elevated body temperature.
• No Significant Anti-inflammatory Effect: Unlike NSAIDs, Paracetamol does not have significant peripheral anti-inflammatory activity. Therefore, it is better suited for mild to moderate pain and fever rather than inflammatory conditions.

Key Advantages:

• Does not irritate the stomach lining, making it safer for children.
• Suitable for children who cannot tolerate oral medications.
• No effect on platelet function or bleeding time, unlike NSAIDs.

ADOL 125mg Interactions ADOL 125mg

Although Paracetamol is considered relatively safe, it may still interact with other medications. It is essential to inform the healthcare provider of all medicines the child is taking, including over-the-counter drugs and supplements.

• Enzyme Inducers (e.g., Carbamazepine, Rifampicin, Phenytoin): These drugs can increase the metabolism of Paracetamol, reducing its effectiveness and increasing the risk of liver toxicity at higher doses.
• Chloramphenicol: Paracetamol may increase the plasma concentration and toxicity of chloramphenicol in children.
• Warfarin and other anticoagulants: Prolonged use of Paracetamol at high doses may enhance the anticoagulant effect of Warfarin, increasing bleeding risk.
• Alcohol: Chronic alcohol consumption can enhance the hepatotoxic effects of Paracetamol.
• Metoclopramide and Domperidone: May increase the rate of absorption of Paracetamol by accelerating gastric emptying.

Clinical Recommendation:

• Avoid combining with other products containing Paracetamol to prevent overdose.
• Monitor liver function when used long-term or with hepatotoxic agents.
• Use with caution if the child is taking anticonvulsants or undergoing antibiotic therapy.

Dosage of ADOL 125mg

The dosage of ADOL 125mg should be based on the child’s age and weight, and should always follow the guidance of a healthcare professional.

• General Pediatric Dose (for 125mg strength):
• For children 6 to 12 months: 1 suppository every 6 to 8 hours as needed
• For children 1 to 5 years: May use 1 to 2 suppositories every 6 to 8 hours as prescribed
• Maximum: Do not exceed 4 doses (500mg) in 24 hours
• Use in special populations:
• In case of hepatic or renal impairment, dose adjustments are necessary.
• In neonates and infants below 6 months, dose must be strictly determined by a physician.

Key Tips:

• Do not use longer than 3 consecutive days without medical advice.
• Monitor for signs of overdose such as nausea, vomiting, or abdominal pain.
• Maintain dosing intervals and do not double doses if a dose is missed.

Possible side effects of ADOL 125mg

Paracetamol, while generally well-tolerated in children, may occasionally cause side effects. These are usually mild and resolve on their own, but some reactions require medical attention.

• Common Side Effects:
• Mild rectal discomfort or irritation after insertion
• Nausea or mild stomach upset
• Skin rash or allergic reaction
• Rare but Serious Side Effects:
• Allergic reactions including swelling of the lips, tongue, or throat (angioedema)
• Hepatotoxicity (especially in case of overdose)
• Severe skin reactions (e.g., Stevens-Johnson syndrome – extremely rare)
• Signs of Overdose:
• Pale skin, sweating, fatigue
• Nausea, vomiting, right upper abdominal pain
• Confusion, irritability, or drowsiness

If any unusual symptoms appear or an overdose is suspected, seek immediate medical attention.

ADOL 125mg Contraindications ADOL 125mg

While Paracetamol suppositories are widely used, there are specific situations where ADOL 125mg should be avoided or used with caution.

• Known Hypersensitivity: Contraindicated in children with known allergy to Paracetamol or any of the suppository’s excipients.
• Severe Hepatic Impairment: Avoid in children with severe liver disease due to the risk of hepatotoxicity.
• Severe Renal Impairment: Use with caution and under strict medical supervision.
• Rectal Conditions: Not recommended in children with rectal bleeding, hemorrhoids, or inflammation as insertion may worsen the condition.
• Multiple Paracetamol Products: Avoid concurrent use with other Paracetamol-containing medications.

Always consult a pediatrician before starting any new medication to ensure safe use.

Storage of ADOL 125mg

Proper storage is essential to preserve the stability and efficacy of rectal suppositories.

• Storage Temperature: Store below 25°C (77°F). Do not freeze.
• Protect from Heat: Avoid exposing the suppositories to high temperatures or direct sunlight, as they can melt.
• Original Packaging: Keep in original blister pack until use to protect from moisture and contamination.
• Keep Out of Reach of Children: Store the medicine in a secure place away from children to prevent accidental ingestion or misuse.
• Do Not Use After Expiry Date: Check the expiry date on the package and discard any expired suppositories.

If the suppository becomes discolored, unusually soft, or shows signs of deterioration, do not use it even if it's within the expiry date.