ADOL 120mg/5ml Suspension

What is ADOL 120mg/5ml

ADOL 120mg/5ml Suspension is an oral liquid formulation that contains Paracetamol (also known as acetaminophen) as the active ingredient. It is commonly used as an analgesic (pain reliever) and antipyretic (fever reducer), especially in pediatric patients. This particular concentration—120mg per 5ml—is specifically designed for children, making it easier to dose based on body weight and age.

• Therapeutic Class: Analgesic and Antipyretic
• Generic Name: Paracetamol
• Form: Oral Suspension
• Strength: 120mg per 5ml
• Pack Size: 100ml bottle

Paracetamol works by reducing the synthesis of prostaglandins in the brain, which helps control pain and regulate body temperature. It is often used to relieve mild to moderate pain such as headaches, toothaches, and musculoskeletal discomfort, as well as to reduce fever in children associated with infections, vaccinations, or other conditions.

ADOL Suspension is considered safe when used according to dosing instructions, and it's a go-to choice for pediatricians and parents alike due to its effectiveness and favorable safety profile compared to other pain relievers like ibuprofen or aspirin, especially in infants and younger children.

How to use ADOL 120mg/5ml

ADOL Suspension must be used exactly as prescribed by a healthcare provider or according to the dosage instructions provided on the label. It is especially important to follow proper dosing in children to prevent the risk of overdose.

• Shake Well: Always shake the bottle well before each use to ensure uniform distribution of the medication.
• Use Measuring Device: Use the measuring spoon or oral syringe provided with the medication. Avoid using kitchen teaspoons as they may lead to inaccurate dosing.
• Administer Orally: Give the suspension by mouth. It can be given with or without food.
• Dosage Interval: Doses can typically be repeated every 4 to 6 hours as needed, but do not exceed 4 doses in 24 hours unless directed by a healthcare provider.
• Age and Weight Considerations: The dose is usually calculated based on the child's weight. A general guideline is 10–15 mg/kg per dose.
• Do Not Exceed Maximum Daily Dose: For children, the maximum dose should not exceed 60 mg/kg/day in divided doses unless prescribed by a doctor.

If a dose is missed, administer it as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give a double dose to make up for a missed one.

Mode of Action ADOL 120mg/5ml

ADOL Suspension contains Paracetamol, which acts both as an analgesic and antipyretic. The precise mechanism of action is not fully understood but is believed to involve central inhibition of prostaglandin synthesis in the brain.

• Analgesic Effect: Paracetamol inhibits cyclooxygenase (COX) enzymes in the brain, particularly COX-3. This reduces the synthesis of prostaglandins that are involved in the transmission of pain signals. As a result, the perception of pain is diminished.
• Antipyretic Effect: It acts on the hypothalamic heat-regulating center to reduce fever. By lowering elevated body temperature through vasodilation and increased heat loss, it provides effective antipyresis without affecting the normal body temperature.
• Peripheral vs Central Action: Unlike nonsteroidal anti-inflammatory drugs (NSAIDs), Paracetamol has minimal anti-inflammatory activity and primarily acts in the central nervous system rather than peripheral tissues.
• Onset of Action: The therapeutic effects typically begin within 30 to 60 minutes after oral administration, with peak effects occurring around 1 to 2 hours.

Due to its central mode of action and low risk of gastrointestinal irritation or bleeding, Paracetamol is often preferred in children and individuals with sensitive stomachs or contraindications to NSAIDs.

ADOL 120mg/5ml Interactions ADOL 120mg/5ml

Although Paracetamol is generally well-tolerated and considered safe, it may interact with certain other drugs. It is important to inform the healthcare provider about all medications the patient is taking, including over-the-counter drugs, herbal supplements, and vitamins.

• Warfarin and Other Anticoagulants: Regular or high doses of Paracetamol may increase the risk of bleeding in patients on anticoagulant therapy.
• Enzyme Inducers (e.g., Carbamazepine, Rifampin, Phenytoin): These drugs can enhance the metabolism of Paracetamol, leading to reduced efficacy or increased hepatotoxicity.
• Alcohol: Chronic alcohol use increases the risk of liver damage with Paracetamol, especially if taken in high doses.
• Isoniazid: Co-administration may increase the hepatotoxic potential of Paracetamol.
• Cholestyramine: May reduce the absorption of Paracetamol if given simultaneously. Space the administration times by at least 1 hour.
• Metoclopramide and Domperidone: May increase the absorption rate of Paracetamol by enhancing gastric emptying.

Always consult with a pharmacist or doctor before starting or stopping any medication when taking ADOL Suspension.

Dosage of ADOL 120mg/5ml

The dosage of ADOL Suspension should be determined based on the child’s weight and age. The usual pediatric dosage is 10 to 15 mg/kg every 4 to 6 hours as needed, but should not exceed 60 mg/kg/day unless prescribed.

• Infants (2–3 months): Only under doctor’s supervision, usually 2.5ml (60mg) once, may be repeated after 4–6 hours if necessary.
• Infants (3–12 months): 2.5ml to 5ml (60–120mg) every 4–6 hours as needed.
• Children (1–5 years): 5ml to 10ml (120–240mg) every 4–6 hours as needed.
• Children (6–12 years): Consider higher-strength formulations or adjust dose accordingly, not typically recommended with 120mg/5ml suspension.
• Maximum Daily Dose: Do not exceed 60 mg/kg/day or 4 doses in 24 hours without medical advice.

ADOL should only be used short-term unless otherwise directed by a physician. For fever longer than 3 days or pain lasting more than 5 days, medical attention is necessary.

Possible side effects of ADOL 120mg/5ml

ADOL is generally well-tolerated in recommended doses, but side effects can occur, particularly with prolonged use or overdose.

• Common Side Effects (rare at therapeutic doses):
  • Nausea
  • Vomiting
  • Loss of appetite
  • Mild abdominal pain
• Allergic Reactions (rare):
  • Rash
  • Itching or hives
  • Swelling of face, lips, or tongue
  • Difficulty breathing (seek emergency care)
• Liver Toxicity (usually in overdose):
  • Yellowing of the skin or eyes (jaundice)
  • Dark urine
  • Unusual tiredness

In children, signs of overdose may also include nausea, vomiting, confusion, and drowsiness. Immediate medical attention is required in such cases.

ADOL 120mg/5ml Contraindications ADOL 120mg/5ml

ADOL Suspension should not be used in individuals who have the following conditions unless advised by a healthcare provider:

• Hypersensitivity: Known allergy to Paracetamol or any other component of the suspension.
• Severe Liver Impairment: Due to the risk of hepatotoxicity, avoid use in patients with serious hepatic dysfunction.
• Severe Renal Impairment: Caution is advised in patients with compromised kidney function; dose adjustments may be needed.
• Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency: Use with caution as Paracetamol may induce hemolysis in rare cases.

Always consult a pediatrician before initiating any treatment in infants, particularly those under 2 months of age.

Storage of ADOL 120mg/5ml

Proper storage of ADOL Suspension ensures its effectiveness and safety for use. The following storage recommendations should be followed:

• Temperature: Store below 25°C (77°F). Do not freeze.
• Keep Away from Sunlight: Protect from direct sunlight and heat sources, as this may degrade the medication.
• Container: Keep the bottle tightly closed and store in its original container.
• After Opening: Once opened, use within the period specified on the bottle (usually 2–3 months) or as instructed by the pharmacist.
• Keep Out of Reach of Children: Store in a secure place to avoid accidental ingestion or misuse.
• Disposal: Do not use expired medication. Dispose of properly through a pharmacy or as per local waste management guidelines.

Always read the storage instructions on the packaging and consult with a healthcare professional if unsure.