LINCOCIN 600mg/2ml Injection

What is LINCOCIN 600mg/2ml

LINCOCIN 600 mg/2 ml is an injectable formulation that contains Roxithromycin, a semi-synthetic macrolide antibiotic used for the treatment of various bacterial infections. While Roxithromycin is more commonly available as an oral medication, this injectable version is formulated for rapid systemic absorption in clinical scenarios where oral administration is not feasible or practical.

• Generic Name: Roxithromycin
• Formulation: 600 mg per 2 ml (300 mg/ml)
• Pharmaceutical Class: Macrolide antibiotic
• Primary Uses: Respiratory tract infections, skin infections, ENT infections, and some urogenital infections

Roxithromycin works by inhibiting bacterial protein synthesis, thus preventing the bacteria from multiplying. It is not effective against viral infections.

How to use LINCOCIN 600mg/2ml

LINCOCIN 600 mg/2 ml should be administered by a qualified healthcare professional. It is typically given via deep intramuscular (IM) injection. It may also be diluted and administered intravenously in some cases, though this depends on formulation specifics and clinical judgment.

• Route: Intramuscular injection
• Dosage Frequency: Typically once or twice daily
• Administration: Under strict aseptic technique
• Monitoring: Monitor for allergic reactions or injection site reactions

Do not self-administer this injection. Always follow the dosing schedule provided by the physician.

Mode of Action LINCOCIN 600mg/2ml

Roxithromycin acts by binding to the 50S ribosomal subunit of susceptible bacteria. This binding inhibits the translocation process of protein elongation, halting bacterial protein synthesis and effectively stopping bacterial replication.

• Bacteriostatic: Stops bacterial growth without directly killing them
• Effective Against: Gram-positive organisms and some Gram-negative and atypical pathogens
• Onset of Action: Typically within 24–48 hours of administration

Its long half-life allows for sustained activity, making it effective with fewer doses compared to some older antibiotics.

LINCOCIN 600mg/2ml Interactions LINCOCIN 600mg/2ml

Roxithromycin, like other macrolides, can interact with several drugs, altering their plasma levels or causing additive effects.

• Warfarin: May enhance anticoagulant effects; monitor INR closely
• Cyclosporine: May increase cyclosporine plasma concentration
• Digoxin: May increase digoxin serum levels, leading to toxicity
• Theophylline: Risk of increased theophylline toxicity
• QT-Prolonging Drugs: Concomitant use increases the risk of arrhythmias

Always inform your healthcare provider about all medications and supplements you're taking.

Dosage of LINCOCIN 600mg/2ml

The exact dosage of LINCOCIN 600 mg/2 ml is determined based on infection severity, patient weight, renal/liver function, and clinical response.

• Typical Adult Dose: 600 mg once daily or 300 mg twice daily via injection
• Pediatric Use: Not commonly recommended; if used, dosing is strictly weight-based
• Renal Impairment: Usually no dose adjustment needed
• Hepatic Impairment: Use with caution; liver enzymes should be monitored

Treatment duration is usually 5–10 days but may be adjusted by the physician.

Possible side effects of LINCOCIN 600mg/2ml

While LINCOCIN is generally well-tolerated, some patients may experience side effects, ranging from mild to serious.

• Common: Injection site pain or redness, nausea, abdominal cramps, diarrhea
• Less Common: Headache, dizziness, skin rash
• Serious: Hepatic dysfunction, severe allergic reaction (anaphylaxis), QT prolongation, arrhythmia

Seek medical attention if you notice signs of liver problems (e.g., yellowing of the skin/eyes), irregular heartbeat, or signs of severe allergic reactions.

LINCOCIN 600mg/2ml Contraindications LINCOCIN 600mg/2ml

• Known hypersensitivity to Roxithromycin or other macrolide antibiotics
• Severe hepatic impairment
• History of cholestatic jaundice during previous macrolide use
• Known QT interval prolongation or use of QT-prolonging medications (use with caution)

Avoid use if the infection is caused by organisms known to be resistant to macrolides.

Storage of LINCOCIN 600mg/2ml

• Store between 15°C and 25°C (59°F–77°F)
• Protect from direct light and moisture
• Do not freeze
• Keep vials in their original box until use

Keep out of reach of children and dispose of unused vials according to local pharmaceutical waste protocols.