LINCOCIN 300mg/ml Injection

What is LINCOCIN 300mg/ml

LINCOCIN 300 mg/ml is a prescription injectable antibiotic containing Roxithromycin, a macrolide-class antimicrobial agent. It is designed to treat a wide range of bacterial infections by inhibiting bacterial protein synthesis. Roxithromycin is typically administered orally; however, in specialized clinical formulations like this injection, it can be used for acute management of infections when oral administration is not feasible.

• Generic Name: Roxithromycin
• Pharmaceutical Form: Injection solution
• Concentration: 300 mg of Roxithromycin per ml
• Primary Uses: Respiratory tract infections, skin and soft tissue infections, and ENT infections caused by susceptible organisms

This medication is to be used under the supervision of a healthcare professional, particularly when oral antibiotics are not effective or cannot be used due to patient condition.

How to use LINCOCIN 300mg/ml

LINCOCIN injection should only be administered by a qualified healthcare provider, either in a hospital or clinical setting. It is typically given via deep intramuscular injection.

• Administration Route: Intramuscular (IM) injection
• Dosage Timing: Usually once or twice daily depending on the infection type and severity
• Do Not Self-Inject: This product is not intended for patient self-administration
• Duration of Treatment: Typically 5–10 days, or as directed by the physician

Your doctor will determine the exact dosage and duration of therapy based on your weight, kidney/liver function, and the nature of the infection.

Mode of Action LINCOCIN 300mg/ml

Roxithromycin, like other macrolides, acts by binding to the 50S subunit of bacterial ribosomes. This prevents the translocation step in protein synthesis, ultimately inhibiting bacterial growth.

• Bacteriostatic Action: Slows bacterial growth and reproduction
• Spectrum: Active against Gram-positive bacteria and some Gram-negative and atypical organisms
• Onset: Depends on infection type; clinical improvement typically seen within 48–72 hours of therapy

It is not effective against viral infections or fungal pathogens.

LINCOCIN 300mg/ml Interactions LINCOCIN 300mg/ml

Roxithromycin may interact with other medications, potentially increasing their effects or risks. Always inform your doctor about any current medications.

• Warfarin or other anticoagulants: May enhance the anticoagulant effect, increasing bleeding risk
• Cyclosporine: Roxithromycin may increase serum levels, requiring monitoring
• Theophylline: May result in elevated blood levels of theophylline
• Digoxin: Roxithromycin may increase digoxin plasma concentration

Avoid combining with other macrolides or QT-prolonging drugs without medical guidance.

Dosage of LINCOCIN 300mg/ml

The exact dosage of LINCOCIN depends on patient-specific factors such as age, weight, severity of infection, and kidney function.

• Adults: Typically 300 mg (1 ml) once or twice daily
• Children: Use with caution; dose based on weight and only under medical supervision
• Renal Impairment: No adjustment usually required, but caution is advised
• Liver Impairment: Dose modification may be necessary

Always follow the physician’s instructions exactly. Do not adjust or skip doses without approval.

Possible side effects of LINCOCIN 300mg/ml

Like all antibiotics, LINCOCIN may cause side effects. While many are mild and self-limiting, some may require medical attention.

• Common: Pain or irritation at injection site, gastrointestinal discomfort, nausea, abdominal pain
• Less Common: Headache, rash, dizziness
• Serious: Liver dysfunction, jaundice, QT interval prolongation, allergic reactions (e.g., anaphylaxis)

Contact a healthcare provider immediately if you experience difficulty breathing, facial swelling, or severe rash.

LINCOCIN 300mg/ml Contraindications LINCOCIN 300mg/ml

• Known hypersensitivity to Roxithromycin or any macrolide antibiotics
• Severe hepatic impairment
• History of cholestatic jaundice related to macrolide use
• Use in patients with QT prolongation or ventricular arrhythmias (with caution)

LINCOCIN is not intended for use in viral infections or when bacterial resistance is suspected.

Storage of LINCOCIN 300mg/ml

• Store at 15°C to 25°C (59°F to 77°F)
• Protect from light and moisture
• Do not freeze
• Keep vials in the original carton until ready for use

Discard any unused or expired vials in accordance with local pharmaceutical waste regulations.