LINCOCIN 500mg Capsules (Hard Gelatin)

What is LINCOCIN 500mg

LINCOCIN 500 mg capsules contain Roxithromycin, a macrolide antibiotic used to treat a variety of bacterial infections, particularly of the respiratory tract, skin, soft tissues, and urogenital system. As a derivative of erythromycin, Roxithromycin is known for its improved gastrointestinal tolerability and better pharmacokinetics, which makes it suitable for once or twice daily oral administration.

• Generic Name: Roxithromycin
• Pharmaceutical Class: Macrolide antibiotic
• Strength: 500 mg per capsule
• Common Uses: Bronchitis, tonsillitis, pharyngitis, sinusitis, skin infections, non-gonococcal urethritis

Roxithromycin works by inhibiting the protein synthesis of bacteria, thereby preventing their growth and spread. It is only effective against bacterial infections and should not be used for viral illnesses such as colds or flu.

How to use LINCOCIN 500mg

LINCOCIN 500 mg capsules are meant to be taken orally with water. The capsules should not be chewed or crushed. They are usually taken once or twice daily, depending on the doctor's prescription and the nature of the infection.

• Standard Adult Dosage: 300–600 mg daily (commonly 150–300 mg twice daily or 500 mg once daily)
• Timing: Best taken on an empty stomach, at least 15 minutes before or 3 hours after meals
• Course Completion: Complete the full course even if symptoms improve early
• Missed Dose: Take it as soon as possible, unless it's almost time for the next dose

Always follow the exact instructions provided by your healthcare provider.

Mode of Action LINCOCIN 500mg

Roxithromycin acts by binding to the 50S ribosomal subunit of susceptible bacteria. This action inhibits the translocation of peptides during protein synthesis, thereby halting bacterial growth.

• Bacteriostatic Action: Inhibits the ability of bacteria to synthesize proteins
• Targets: Effective primarily against Gram-positive cocci and some Gram-negative organisms
• Pharmacokinetics: High tissue penetration, long half-life (~12 hours), and stable serum levels

This mechanism allows for sustained therapeutic levels with relatively fewer doses per day compared to older macrolides.

LINCOCIN 500mg Interactions LINCOCIN 500mg

Roxithromycin can interact with several other medications. These interactions may increase the concentration of other drugs or alter their efficacy.

• Warfarin: May potentiate anticoagulant effect; monitor INR closely
• Cyclosporine: May increase blood levels; dosage adjustment may be needed
• Digoxin: Plasma levels may increase, requiring monitoring
• Theophylline: Risk of increased theophylline levels and potential toxicity
• QT-Prolonging Agents: Co-administration may increase risk of arrhythmias

Inform your healthcare provider of all prescription, over-the-counter, and herbal products you are using.

Dosage of LINCOCIN 500mg

The dosage of LINCOCIN 500 mg depends on the severity of the infection and the patient’s weight, age, and kidney/liver function.

• Adults: 500 mg once daily or 250 mg twice daily
• Children (under 40 kg): Typically not recommended in capsule form; pediatric formulations are advised
• Renal Impairment: No dosage adjustment generally required
• Hepatic Impairment: Use with caution; may require dose modification

Always complete the prescribed course to reduce the risk of bacterial resistance.

Possible side effects of LINCOCIN 500mg

Roxithromycin is generally well tolerated, but some patients may experience side effects.

• Common: Nausea, abdominal discomfort, diarrhea, headache
• Less Common: Taste disturbances, skin rash, elevated liver enzymes
• Serious: Liver dysfunction, QT prolongation, hypersensitivity reactions

Seek immediate medical attention if you develop symptoms such as swelling of the face/lips, difficulty breathing, or severe skin rash.

LINCOCIN 500mg Contraindications LINCOCIN 500mg

• Known allergy to Roxithromycin or other macrolides
• Severe hepatic impairment
• History of cholestatic jaundice with prior macrolide use
• Use in patients with QT prolongation or ventricular arrhythmia (use caution)

Not suitable for viral infections or when bacterial resistance is known or suspected.

Storage of LINCOCIN 500mg

• Store below 25°C (77°F)
• Keep in original packaging to protect from moisture and light
• Keep out of reach of children
• Do not use after the expiration date on the blister or box

Improper storage may reduce the effectiveness and safety of the medicine.