What is ACYCLOVIR SODIUM FOR INJECTION 1g
Acyclovir Sodium for Injection 1g is a sterile, lyophilized powder intended for intravenous infusion after reconstitution and dilution. It contains the antiviral agent acyclovir, a synthetic purine nucleoside analog with potent activity against herpesviruses.
Indications:
- Herpes Simplex Virus (HSV) Infections: Treatment of initial and recurrent mucocutaneous HSV infections in immunocompromised patients.
- Herpes Simplex Encephalitis: Management of HSV infections of the central nervous system.
- Neonatal HSV Infections: Treatment of disseminated or localized HSV infections in neonates.
- Varicella-Zoster Virus (VZV) Infections: Treatment of varicella (chickenpox) and herpes zoster (shingles) in immunocompromised individuals.
This formulation is particularly beneficial for patients unable to take oral medications or those requiring high plasma concentrations of acyclovir.
How to use ACYCLOVIR SODIUM FOR INJECTION 1g
Preparation:
- Reconstitute the 1g vial with 20 mL of sterile water for injection to obtain a solution with a concentration of 50 mg/mL.
- Shake well until the powder dissolves completely.
- Further dilute the reconstituted solution in a compatible intravenous fluid (e.g., 0.9% Sodium Chloride Injection) to achieve a final concentration not exceeding 5 mg/mL.
Administration:
- Infuse the diluted solution intravenously over at least 1 hour to minimize the risk of renal toxicity.
- Ensure adequate hydration of the patient during treatment to support renal function.
- Do not administer as a bolus injection or via intramuscular or subcutaneous routes.
Precautions:
- Monitor renal function before and during therapy, especially in patients with pre-existing renal impairment.
- Adjust dosage accordingly to prevent accumulation and toxicity.
Mode of Action ACYCLOVIR SODIUM FOR INJECTION 1g
Acyclovir exhibits antiviral activity by interfering with viral DNA synthesis. Its mechanism involves:
- Selective Uptake: Acyclovir is preferentially taken up by virus-infected cells.
- Phosphorylation: Viral thymidine kinase phosphorylates acyclovir to acyclovir monophosphate.
- Further Activation: Host cell enzymes convert the monophosphate to acyclovir triphosphate.
- Inhibition of Viral DNA Polymerase: Acyclovir triphosphate competitively inhibits viral DNA polymerase, leading to chain termination during viral DNA replication.
This selective mechanism ensures minimal impact on uninfected cells, thereby reducing host toxicity.
ACYCLOVIR SODIUM FOR INJECTION 1g Interactions ACYCLOVIR SODIUM FOR INJECTION 1g
Drug-Drug Interactions:
- Probenecid: May decrease renal clearance of acyclovir, leading to increased plasma concentrations.
- Other Nephrotoxic Agents: Concurrent use with drugs like cyclosporine or tacrolimus can enhance the risk of renal dysfunction.
- Mycophenolate Mofetil: Co-administration may increase plasma levels of both drugs.
Laboratory Test Interactions:
- No significant interference with laboratory tests has been reported.
Always review the patient's medication profile to identify potential interactions before initiating therapy.
Dosage of ACYCLOVIR SODIUM FOR INJECTION 1g
General Guidelines:
- Dosage is based on the patient's weight, renal function, and the severity of the infection.
- Administered intravenously over at least 1 hour.
Adults and Adolescents (≥12 years):
- HSV Infections: 5 mg/kg every 8 hours for 7 days.
- Herpes Encephalitis: 10 mg/kg every 8 hours for 10 days.
- VZV Infections: 10 mg/kg every 8 hours for 7 days.
Children (3 months to 12 years):
- HSV Infections: 10 mg/kg every 8 hours for 7 days.
- Herpes Encephalitis: 20 mg/kg every 8 hours for 10 days.
- VZV Infections: 20 mg/kg every 8 hours for 7 days.
Neonates (≤28 days):
- HSV Infections: 20 mg/kg every 8 hours for 21 days.
Renal Impairment:
- Dosage adjustments are necessary based on creatinine clearance levels.
- Monitor renal function closely during therapy.
Possible side effects of ACYCLOVIR SODIUM FOR INJECTION 1g
Common Adverse Effects:
- Local Reactions: Inflammation or phlebitis at the injection site.
- Gastrointestinal: Nausea, vomiting, abdominal pain.
- Neurological: Headache, dizziness.
Serious Adverse Effects:
- Renal: Elevated blood urea nitrogen (BUN) and serum creatinine, acute renal failure.
- Neurological: Agitation, hallucinations, confusion, seizures (particularly in patients with renal impairment).
- Hematologic: Thrombocytopenia, leukopenia.
- Hypersensitivity: Rash, pruritus, anaphylaxis.
Promptly report any severe or unusual symptoms to a healthcare provider.
ACYCLOVIR SODIUM FOR INJECTION 1g Contraindications ACYCLOVIR SODIUM FOR INJECTION 1g
Absolute Contraindications:
- Known hypersensitivity to acyclovir, valacyclovir, or any component of the formulation.
Relative Contraindications:
- Renal Impairment: Use with caution; dosage adjustments required.
- Neurological Disorders: History of seizures or other neurological abnormalities may increase risk of neurotoxicity.
Assess patient history thoroughly before initiating therapy.
Storage of ACYCLOVIR SODIUM FOR INJECTION 1g
Unreconstituted Vials:
- Store at controlled room temperature between 20°C to 25°C (68°F to 77°F).
- Protect from light and moisture.
Reconstituted Solution:
- Use immediately after reconstitution.
- If necessary, store at 2°C to 8°C (36°F to 46°F) for up to 24 hours.
Diluted Infusion Solution:
- Use within 24 hours when stored at 2°C to 8°C (36°F to 46°F).
- Discard any unused portion after this period.
Always adhere to institutional guidelines and manufacturer's instructions for preparation and storage.
ACYCLOVIR SODIUM FOR INJECTION 1g features an exceptional active ingredient renowned for its potent effects, comprising Aciclovir. This powerful formulation provides a superior solution for addressing diverse health concerns. With 1g/Vial concentration and an easily manageable Infusion/Powder for, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ACYCLOVIR SODIUM FOR INJECTION 1g .
Welcome to Dwaey, specifically on ACYCLOVIR SODIUM FOR INJECTION 1g page.
This medicine contains an important and useful components, as it consists of Aciclovir.
ACYCLOVIR SODIUM FOR INJECTION 1g is available in the market in concentration 1g/Vial and in the form of Infusion/Powder for.
ABBOTT LABORATORIES is the producer of ACYCLOVIR SODIUM FOR INJECTION 1g and it is imported from USA,
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Frequently Asked Questions
ACYCLOVIR SODIUM FOR INJECTION 1g should be stored according to the instructions provided by ABBOTT LABORATORIES.
In general, it is recommended to store ACYCLOVIR SODIUM FOR INJECTION 1g in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ACYCLOVIR SODIUM FOR INJECTION 1g may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ACYCLOVIR SODIUM FOR INJECTION 1g for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ACYCLOVIR SODIUM FOR INJECTION 1g. Some medications, including
ACYCLOVIR SODIUM FOR INJECTION 1g, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ACYCLOVIR SODIUM FOR INJECTION 1g, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ACYCLOVIR SODIUM FOR INJECTION 1g without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ACYCLOVIR SODIUM FOR INJECTION 1g if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ACYCLOVIR SODIUM FOR INJECTION 1g during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 1g/Vial,
and the specific recommendations of ABBOTT LABORATORIES.
The effects of ACYCLOVIR SODIUM FOR INJECTION 1g on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 1g/Vial, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ACYCLOVIR SODIUM FOR INJECTION 1g with or without food may vary depending on the medication
and the recommendations of ABBOTT LABORATORIES. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ACYCLOVIR SODIUM FOR INJECTION 1g in children or elderly individuals may depend on various factors, including
the specific medication, type Infusion/Powder for, and the recommendations of ABBOTT LABORATORIES. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ACYCLOVIR SODIUM FOR INJECTION 1g in children or elderly individuals.
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All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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