ACLONIA 70mg/2,800 IU Tablet

What is ACLONIA 70mg/2,800 IU

ACLONIA 70 mg/2,800 IU is a combination medication containing two active ingredients: Alendronic acid (70 mg), a bisphosphonate, and Cholecalciferol (Vitamin D3, 2800 IU). It is formulated in a tablet form, typically packed in 4's blisters and prescribed as a once-weekly treatment.

This combination is specifically indicated for the treatment of osteoporosis in postmenopausal women and men who are at increased risk of fractures. Osteoporosis is a condition where bones become thin and fragile, increasing the likelihood of fractures, especially in the spine, hips, and wrists.

Alendronic acid works by inhibiting the breakdown of bone (resorption), which helps to maintain or increase bone density. Cholecalciferol (Vitamin D3) supports calcium absorption from the intestine and plays a key role in bone health, making the combination effective in managing bone disorders related to calcium deficiency and bone turnover.

ACLONIA is ideal for patients requiring both osteoporosis treatment and Vitamin D supplementation in one convenient tablet, enhancing compliance and therapeutic benefit.

How to use ACLONIA 70mg/2,800 IU

Proper administration of ACLONIA is essential to maximize its benefits and minimize potential side effects, particularly gastrointestinal issues:

• Frequency: Take one tablet once a week on the same day each week.
• Timing: Take in the morning upon waking, before consuming any food, drink, or other medication.
• Swallow whole: Use a full glass (180–240 mL) of plain water. Do not chew, crush, or suck the tablet.
• Stay upright: Remain sitting or standing for at least 30 minutes after taking the tablet to prevent esophageal irritation or ulceration.
• Wait before eating: Do not eat or drink anything (other than water) or take other medications or supplements for at least 30 minutes after ingestion.
• Do not take at bedtime or before rising: This increases the risk of tablet reflux into the esophagus, which can cause damage.

If a dose is missed, take it the next morning after you remember, then return to your regular schedule. Do not take two tablets on the same day.

Mode of Action ACLONIA 70mg/2,800 IU

ACLONIA exerts its therapeutic effects through two synergistic mechanisms provided by its active ingredients:

• Alendronic acid:
  • It belongs to a class of drugs called bisphosphonates.
  • It inhibits the activity of osteoclasts, the cells responsible for breaking down bone tissue (bone resorption).
  • This leads to reduced bone turnover, resulting in increased bone mineral density (BMD) and reduced risk of fractures.
• Cholecalciferol (Vitamin D3):
  • Essential for calcium absorption from the gastrointestinal tract.
  • Helps maintain serum calcium and phosphate levels, which are critical for healthy bone mineralization.
  • Prevents secondary hyperparathyroidism and supports muscle function to reduce fall risk.

The combined action of Alendronic acid and Cholecalciferol in ACLONIA enhances both bone structure and calcium homeostasis, offering comprehensive osteoporosis treatment.

ACLONIA 70mg/2,800 IU Interactions ACLONIA 70mg/2,800 IU

Interactions with other drugs or substances can influence the effectiveness and safety of ACLONIA. Be cautious with the following:

• Calcium or antacids: Supplements containing calcium, magnesium, aluminum, or iron may reduce the absorption of Alendronic acid. Avoid taking them within 30 minutes of ACLONIA.
• NSAIDs: Concurrent use with non-steroidal anti-inflammatory drugs may increase the risk of gastrointestinal irritation or ulcers.
• Other bisphosphonates: Should not be taken with ACLONIA to prevent overdose or increased side effects.
• Diuretics (e.g., thiazides): May increase the risk of hypercalcemia when combined with high doses of Vitamin D.
• Digitalis glycosides (e.g., digoxin): Hypercalcemia from excessive Vitamin D may enhance digitalis toxicity.
• Vitamin D analogs: Using multiple sources of Vitamin D can increase the risk of toxicity. Total intake should be monitored.

Always inform your healthcare provider about all medications, including supplements and herbal products, to avoid harmful interactions.

Dosage of ACLONIA 70mg/2,800 IU

The dosage regimen for ACLONIA is straightforward and designed to enhance patient compliance:

• Standard dose: One tablet (70 mg Alendronic acid / 2800 IU Cholecalciferol) once weekly.
• Patient population: Primarily for adults with:
  • Postmenopausal osteoporosis
  • Osteoporosis in men
  • Vitamin D deficiency associated with bone loss
• Administration: Should be taken first thing in the morning, on an empty stomach, with a full glass of water.
• Missed dose: If you forget to take a dose, take it the next morning after you remember. Resume your usual schedule the following week. Do not double up.

Patients should also maintain adequate intake of calcium and other nutrients essential for bone health, unless contraindicated.

Possible side effects of ACLONIA 70mg/2,800 IU

While many patients tolerate ACLONIA well, some may experience side effects. These can be mild to serious and may include:

• Gastrointestinal:
  • Abdominal pain
  • Dyspepsia (indigestion)
  • Esophagitis or esophageal ulcers (especially if not taken properly)
  • Nausea or vomiting
• Musculoskeletal:
  • Bone, joint, or muscle pain
  • Rare cases of severe bone pain or atypical femoral fractures
• Oral and jaw issues:
  • Osteonecrosis of the jaw, especially after dental procedures
• Vitamin D effects:
  • Hypercalcemia (excess calcium in blood)
  • Symptoms may include fatigue, weakness, headache, or constipation
• Allergic reactions:
  • Rash, itching, or swelling
  • Rare: anaphylaxis

Report any unusual or persistent symptoms to your healthcare provider. Early identification helps prevent serious complications.

ACLONIA 70mg/2,800 IU Contraindications ACLONIA 70mg/2,800 IU

ACLONIA is not suitable for everyone. It is contraindicated in the following conditions:

• Hypersensitivity: Allergy to Alendronic acid, Cholecalciferol, or any excipients in the tablet.
• Esophageal abnormalities: Conditions that delay esophageal emptying such as strictures or achalasia.
• Inability to sit or stand upright: Patients who cannot remain upright for at least 30 minutes.
• Hypocalcemia: Low blood calcium must be corrected before starting treatment.
• Severe kidney impairment: Generally not recommended if creatinine clearance is <35 mL/min.
• Vitamin D toxicity: Should not be used in patients with hypervitaminosis D or those at risk for hypercalcemia.

A thorough evaluation by a healthcare provider is essential before initiating ACLONIA therapy.

Storage of ACLONIA 70mg/2,800 IU

• Store at room temperature: 15°C to 30°C (59°F to 86°F).
• Protect from moisture and direct sunlight.
• Keep tablets in their original blister packaging until time of use.
• Do not store in humid areas such as bathrooms.
• Keep out of reach of children and pets.
• Do not use beyond the expiry date mentioned on the packaging.
• Properly discard expired or unused medication according to local pharmacy or waste disposal guidelines.