ACETAMOL ADULTS 500mg Tablets

What is ACETAMOL ADULTS 500mg

ACETAMOL ADULTS 500mg is an oral tablet formulation of Paracetamol (also known as Acetaminophen), widely recognized for its analgesic (pain-relieving) and antipyretic (fever-reducing) properties. It is one of the most commonly used medications worldwide due to its effectiveness and safety profile when used appropriately.

This specific 500mg strength is intended for adults and adolescents over 12 years of age. It is often used to treat a variety of conditions such as:

• Headaches and migraines
• Muscle aches, back pain, and general body pain
• Dental pain or toothache
• Fever associated with infections like influenza or colds
• Menstrual cramps
• Minor arthritis pain or osteoarthritis

ACETAMOL does not possess anti-inflammatory effects, making it ideal for patients who need pain relief but cannot tolerate non-steroidal anti-inflammatory drugs (NSAIDs).

How to use ACETAMOL ADULTS 500mg

Proper usage of ACETAMOL ADULTS 500mg ensures optimal relief with minimal risk of adverse effects. Follow these usage guidelines:

• Dosage form: Oral tablet. Swallow whole with a glass of water. Do not chew or crush unless directed.
• With or without food: Can be taken on an empty stomach; however, taking it with food can reduce gastrointestinal discomfort.
• Timing: Usually every 4 to 6 hours as needed for pain or fever.

Key recommendations:

• Do not exceed 4000mg (8 tablets) in a 24-hour period.
• Minimum interval between doses should be 4 hours.
• Avoid using other products that contain paracetamol to prevent overdose.
• Discontinue use and consult a healthcare provider if symptoms last more than 3 days (fever) or 5 days (pain).

Mode of Action ACETAMOL ADULTS 500mg

Paracetamol works by affecting both the central nervous system and the body’s temperature regulation system:

• Analgesic action: It inhibits the enzyme cyclooxygenase (COX) in the brain, reducing the synthesis of prostaglandins—chemicals involved in pain signaling. This results in effective central pain relief.
• Antipyretic action: It acts on the hypothalamus (the body's thermostat) to lower elevated body temperature by increasing peripheral blood flow and sweating, thereby dissipating heat.

Notably, unlike NSAIDs, paracetamol has minimal anti-inflammatory effects and does not cause gastrointestinal irritation or platelet inhibition, making it safer for people with gastric ulcers or bleeding disorders.

ACETAMOL ADULTS 500mg Interactions ACETAMOL ADULTS 500mg

While paracetamol has a relatively low interaction profile, some substances can increase the risk of toxicity or reduce efficacy:

• Alcohol: Chronic alcohol use increases the risk of liver damage with paracetamol.
• Warfarin and other anticoagulants: Regular use may enhance anticoagulant effect, increasing the risk of bleeding.
• Rifampicin, Phenytoin, Carbamazepine: These drugs can increase metabolism of paracetamol into toxic metabolites.
• Isoniazid: May increase the risk of hepatotoxicity.
• Cholestyramine: May reduce paracetamol absorption if taken too closely together.
• Metoclopramide or Domperidone: May increase the speed of paracetamol absorption and onset of action.

Always disclose all medications and supplements to your healthcare provider to avoid harmful interactions.

Dosage of ACETAMOL ADULTS 500mg

Correct dosing is critical to ensure efficacy and safety:

• Adults and adolescents over 12 years: 500mg to 1000mg (1–2 tablets) every 4–6 hours as needed.
• Maximum daily dose: Do not exceed 4000mg (8 tablets) in 24 hours.
• Elderly: Same dosing as adults, but monitor liver function closely.

Missed Dose:

• Take as soon as you remember unless it's almost time for the next dose.
• Do not double the dose to make up for a missed one.

Overdose Warning: Taking more than the recommended dose can cause serious liver damage. In cases of overdose, seek emergency medical attention immediately—even if symptoms are not yet present.

Possible side effects of ACETAMOL ADULTS 500mg

Paracetamol is generally well tolerated, but side effects can occasionally occur:

• Common: Generally rare at recommended doses. Most users experience no side effects.
• Uncommon to Rare:
  • Nausea or abdominal discomfort
  • Allergic skin reactions (rash, itching)
  • Blood disorders such as thrombocytopenia or leukopenia
• Serious (usually linked to overdose or prolonged use):
  • Hepatic injury or liver failure
  • Renal dysfunction
  • Anaphylactic reactions (swelling, breathing difficulty)

If you experience yellowing of the eyes or skin, dark urine, or unusual bleeding, stop taking the medicine and consult a healthcare provider immediately.

ACETAMOL ADULTS 500mg Contraindications ACETAMOL ADULTS 500mg

ACETAMOL should not be used in the following scenarios:

• Known hypersensitivity to paracetamol or any excipients in the tablet
• Severe liver disease or active hepatic impairment
• History of alcohol abuse or dependence

Use with caution in:

• Renal impairment
• Malnourished individuals (increased risk of liver toxicity)
• Dehydrated patients
• Chronic use or prolonged treatment duration

Always consult a doctor before long-term use or if you are on multiple medications.

Storage of ACETAMOL ADULTS 500mg

Proper storage maintains the quality and effectiveness of the medicine:

• Temperature: Store at controlled room temperature, typically between 15°C and 30°C (59°F to 86°F).
• Moisture: Keep in a dry place; avoid storing in bathrooms or humid areas.
• Light: Protect from direct sunlight. Keep in original packaging.
• Child safety: Store out of reach of children to prevent accidental ingestion.
• Expiry: Do not use the medication past the expiration date indicated on the packaging.

Unused or expired medicine should be discarded safely in accordance with local regulations to avoid accidental misuse or environmental harm.