ACEREM 250mg Tablets

What is ACEREM 250mg

ACEREM 250 mg contains acetazolamide, a carbonic anhydrase inhibitor used to manage various conditions by altering fluid and electrolyte balance in the body. It is commonly prescribed for:

• Glaucoma: Reduces intraocular pressure by decreasing aqueous humor production.
• Epilepsy: Serves as an adjunctive therapy for certain seizure types, including absence seizures.
• Altitude Sickness: Prevents and alleviates symptoms by promoting acclimatization.
• Edema: Addresses fluid retention associated with congestive heart failure or drug-induced causes.
• Idiopathic Intracranial Hypertension: Lowers cerebrospinal fluid production to reduce intracranial pressure.

Acetazolamide's versatility stems from its ability to inhibit carbonic anhydrase, affecting various physiological processes.

How to use ACEREM 250mg

Proper administration of ACEREM ensures optimal efficacy and minimizes potential side effects:

• Dosage: Follow your healthcare provider's instructions. Dosage varies based on the condition being treated.
• Administration: Take orally with a full glass of water. It can be taken with or without food.
• Consistency: Take at the same times each day to maintain steady blood levels.
• Missed Dose: If you miss a dose, take it as soon as you remember. If it's near the time of your next dose, skip the missed dose. Do not double up.
• Hydration: Maintain adequate fluid intake to prevent kidney stones and dehydration.
• Monitoring: Regularly monitor blood electrolytes and kidney function during prolonged use.

Always consult your doctor before making any changes to your medication regimen.

Mode of Action ACEREM 250mg

Acetazolamide exerts its therapeutic effects by inhibiting the enzyme carbonic anhydrase, leading to:

• Renal Effects: Decreased reabsorption of bicarbonate, sodium, and chloride in the proximal tubules, resulting in increased diuresis and altered acid-base balance.
• Ocular Effects: Reduced aqueous humor formation, lowering intraocular pressure beneficial in glaucoma management.
• Central Nervous System Effects: Modulation of neuronal excitability, contributing to its anticonvulsant properties.
• Respiratory Effects: Induction of metabolic acidosis stimulates ventilation, aiding in acclimatization to high altitudes.

This multifaceted mechanism allows acetazolamide to be effective across various medical conditions.

ACEREM 250mg Interactions ACEREM 250mg

Acetazolamide may interact with several medications, necessitating caution:

• Aspirin: High doses may increase the risk of metabolic acidosis and CNS toxicity.
• Phenytoin: May alter phenytoin metabolism, affecting seizure control.
• Primidone: Can decrease serum levels, reducing its anticonvulsant efficacy.
• Lithium: Increases lithium excretion, potentially reducing its effectiveness.
• Cyclosporine: May elevate cyclosporine levels, increasing toxicity risk.
• Antidiabetic Agents: Can cause fluctuations in blood glucose levels.
• Methenamine: Reduces its urinary antiseptic effect.
• Sodium Bicarbonate: Concurrent use increases the risk of kidney stone formation.

Always inform your healthcare provider about all medications and supplements you are taking.

Dosage of ACEREM 250mg

Dosage should be individualized based on the specific condition and patient response:

• Glaucoma: 250 mg to 1000 mg daily in divided doses.
• Epilepsy: 8 to 30 mg/kg/day in divided doses; adjust based on therapeutic response.
• Altitude Sickness: 250 mg twice daily, starting 1-2 days before ascent and continuing for 48 hours after reaching altitude.
• Edema: 250 mg to 375 mg once daily in the morning; may be increased as needed.
• Idiopathic Intracranial Hypertension: Dosage varies; initiate at 500 mg to 1000 mg daily in divided doses, adjusting as necessary.

Regular monitoring of blood electrolytes and kidney function is recommended during therapy.

Possible side effects of ACEREM 250mg

While acetazolamide is generally well-tolerated, some individuals may experience side effects:

• Common: Paresthesia (tingling), fatigue, dizziness, nausea, vomiting, loss of appetite, and increased urination.
• Less Common: Taste alterations, diarrhea, photosensitivity, and mood changes.
• Serious: Severe skin reactions (e.g., Stevens-Johnson syndrome), blood disorders, liver dysfunction, electrolyte imbalances, and kidney stones.

Seek immediate medical attention if you experience signs of a severe allergic reaction, significant mood changes, or symptoms of electrolyte imbalance.

ACEREM 250mg Contraindications ACEREM 250mg

Do not use acetazolamide if you have:

• Known hypersensitivity to acetazolamide or sulfonamide derivatives.
• Severe liver disease or dysfunction.
• Severe kidney impairment or disease.
• Adrenal gland failure (e.g., Addison's disease).
• Electrolyte imbalances such as hyponatremia or hypokalemia.
• Hyperchloremic acidosis.
• Chronic non-congestive angle-closure glaucoma.

Consult your healthcare provider before initiating therapy, especially if you have underlying health conditions.

Storage of ACEREM 250mg

Proper storage ensures medication efficacy and safety:

• Store at room temperature between 20°C and 25°C (68°F–77°F).
• Keep in the original blister packaging to protect from moisture and light.
• Do not store in the bathroom or areas with high humidity.
• Keep out of reach of children and pets.
• Do not use beyond the expiration date printed on the packaging.
• Dispose of unused or expired medication according to local regulations or return to a pharmacy.

Maintaining proper storage conditions preserves the medication's integrity and effectiveness.