ACEFLAM 100mg Tablets/Film-coated

What is ACEFLAM 100mg

ACEFLAM 100 mg is a prescription medication that contains Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID). It is primarily used for the treatment of pain and inflammation associated with musculoskeletal disorders and arthritis-related conditions.

This medication is commonly prescribed for the following indications:

• Osteoarthritis – Degenerative joint disease causing pain and stiffness
• Rheumatoid arthritis – An autoimmune condition that causes joint inflammation
• Ankylosing spondylitis – A chronic inflammatory disease of the spine and sacroiliac joints
• Musculoskeletal injuries – Such as strains, sprains, and soft tissue trauma

ACEFLAM is valued for its relatively favorable gastrointestinal tolerability compared to older NSAIDs and provides a balance of anti-inflammatory and analgesic activity. It does not cure the underlying condition but helps reduce symptoms and improve mobility and quality of life.

How to use ACEFLAM 100mg

Proper usage of ACEFLAM 100 mg ensures maximum efficacy and minimizes the risk of adverse effects. Follow your healthcare provider’s instructions precisely.

• Dosage frequency: Typically one tablet (100 mg) twice daily – once in the morning and once in the evening.
• Administration: Take the tablet orally with a full glass of water. Swallow whole without chewing or crushing.
• Timing: Take the tablet with or immediately after food to reduce stomach irritation.
• Consistency: Take it at the same times each day to maintain even levels in your system.
• Missed dose: If you miss a dose, take it when you remember. If it’s almost time for your next dose, skip the missed one. Never double the dose.

Important: Do not exceed the recommended dose or duration unless specifically directed by your doctor.

Mode of Action ACEFLAM 100mg

Aceclofenac, the active ingredient in ACEFLAM, works by inhibiting an enzyme called cyclooxygenase (COX). This enzyme is responsible for the production of prostaglandins—chemical mediators that play a key role in pain, inflammation, and fever.

Mechanisms of action include:

• Inhibition of COX-2: Reduces the synthesis of pro-inflammatory prostaglandins at the site of injury or inflammation.
• Peripheral analgesic effect: Blocks the generation of pain signals in injured tissues.
• Improved gastrointestinal tolerance: Aceclofenac is selectively COX-2 preferential, meaning it causes less COX-1 inhibition (responsible for protecting the gastric lining) than some other NSAIDs like diclofenac or indomethacin.

The onset of action is usually within a few hours, and the therapeutic effects can be observed with consistent use over a few days, particularly in chronic conditions like arthritis.

ACEFLAM 100mg Interactions ACEFLAM 100mg

Aceclofenac may interact with various medications, either by enhancing side effects or reducing the effectiveness of one or both drugs. Be sure to inform your doctor of all prescription, OTC, and herbal products you’re using.

• Anticoagulants (e.g., warfarin): May increase bleeding risk.
• Antihypertensives (ACE inhibitors, ARBs, beta-blockers): NSAIDs may reduce their blood pressure-lowering effect.
• Diuretics: Risk of kidney impairment increases.
• Methotrexate: May increase toxicity due to decreased renal clearance.
• Cyclosporine: Enhanced nephrotoxic potential.
• Other NSAIDs or corticosteroids: Higher chance of gastrointestinal bleeding or ulceration.
• Digoxin: Potential increase in plasma digoxin concentration.

Use of alcohol can further irritate the stomach lining and increase the risk of GI side effects when combined with ACEFLAM.

Dosage of ACEFLAM 100mg

The standard dosing guideline for ACEFLAM 100 mg is as follows:

• Adults: One tablet (100 mg) twice daily
• Take with food: To minimize the risk of gastrointestinal disturbances

Special considerations:

• Elderly patients: Start at the lowest effective dose due to increased sensitivity and risk of side effects
• Hepatic or renal impairment: Use with caution; consult a physician for dosage adjustment or alternative therapies
• Children: Not recommended for pediatric use unless specifically directed by a specialist

Do not take more than 200 mg in a 24-hour period unless advised by a healthcare professional. Regular follow-up is important if the medication is used for prolonged periods.

Possible side effects of ACEFLAM 100mg

ACEFLAM 100 mg is generally well tolerated but may cause side effects in some individuals. These can range from mild to serious:

Common side effects:

• Stomach pain, indigestion, or nausea
• Diarrhea or constipation
• Dizziness or headache
• Skin rash or itching

Less common but potentially serious side effects:

• Gastrointestinal bleeding or ulcers (signs include black stools or vomiting blood)
• Elevated liver enzymes or jaundice
• Kidney dysfunction (e.g., changes in urination, swelling in legs)
• Allergic reactions including angioedema, anaphylaxis (rare but severe)

Warning: Stop using ACEFLAM and seek immediate medical attention if you experience difficulty breathing, severe stomach pain, visual disturbances, or symptoms suggestive of an allergic reaction.

ACEFLAM 100mg Contraindications ACEFLAM 100mg

ACEFLAM should not be used in patients with the following conditions:

• Allergy to Aceclofenac or other NSAIDs
• History of NSAID-induced asthma or allergic reactions
• Active peptic ulcer disease or history of recurrent GI bleeding
• Severe hepatic, renal, or cardiac impairment
• Third trimester of pregnancy
• Breastfeeding women (use only if benefits outweigh risks)
• Children and adolescents under 18 years (unless prescribed by a specialist)

Always consult your doctor to evaluate the risks and benefits before initiating treatment, especially if you have a history of cardiovascular disease or gastrointestinal disorders.

Storage of ACEFLAM 100mg

Proper storage ensures the safety and effectiveness of your medication. Follow these storage recommendations:

• Temperature: Store below 25°C (77°F) in a dry place
• Humidity: Keep away from moisture and humidity; avoid storing in the bathroom
• Original packaging: Keep tablets in the original blister pack to protect from light and contamination
• Children and pets: Store out of reach to prevent accidental ingestion
• Expiration date: Do not use after the expiry date printed on the packaging

If the tablets appear discolored or altered, do not use them. Return any expired or unused medication to your pharmacy for proper disposal.