DAIVOBET Ointment

What is DAIVOBET

DAIVOBET Ointment is a topical dermatological medication containing Adapalene 0.3% as its active ingredient. It is specifically formulated for the treatment of severe acne vulgaris and related inflammatory skin conditions. Adapalene, a synthetic retinoid, regulates skin cell turnover and reduces inflammation, helping to prevent the formation of acne lesions such as comedones, papules, and pustules. Packaged in a convenient 30g collapsible tube, DAIVOBET ensures easy, hygienic, and precise application to affected areas.

• Generic Name: Adapalene 0.3%
• Form: Ointment
• Main Indications: Severe acne vulgaris, follicular keratosis, and sometimes off-label for other keratinization disorders.

Its higher concentration (0.3%) makes it particularly suited for patients whose acne is resistant to lower strength retinoid therapies.

How to use DAIVOBET

Correct use of DAIVOBET maximizes treatment benefits while minimizing side effects:

• Preparation: Gently cleanse the affected area with a mild soap or cleanser and allow it to dry completely before application.
• Application: Apply a thin layer of the ointment over the entire affected area once daily, preferably in the evening.
• Technique: Use clean fingers to spread the ointment lightly; avoid rubbing it in forcefully.
• Avoid Sensitive Areas: Do not apply near the eyes, lips, or inside the nostrils.
• Additional Measures: Moisturize regularly to combat dryness and always use sunscreen during the day.

Consistency is key; visible improvement may take several weeks, and initial irritation is common but typically resolves with continued use.

Mode of Action DAIVOBET

DAIVOBET exerts its therapeutic effects through the following mechanisms:

• Regulation of Keratinization: Adapalene normalizes the differentiation of follicular epithelial cells, thereby preventing the formation of microcomedones (early acne lesions).
• Anti-inflammatory Effects: It inhibits key inflammatory mediators such as prostaglandins and leukotrienes, reducing redness and swelling in acne lesions.
• Comedolytic Action: Adapalene helps to unclog pores by promoting the natural shedding of dead skin cells.
• Selective Retinoid Receptor Activity: It selectively binds to retinoic acid receptors (RAR-β and RAR-γ), minimizing irritation compared to first-generation retinoids.

This multi-pronged mode of action makes DAIVOBET highly effective for treating both inflammatory and non-inflammatory acne lesions.

DAIVOBET Interactions DAIVOBET

Certain drug interactions need to be considered when using DAIVOBET:

• Other Topical Products: Use caution when combining with other topical treatments containing sulfur, resorcinol, or salicylic acid, as this may lead to excessive skin irritation.
• Photosensitizing Agents: Concomitant use with medications that increase photosensitivity (such as certain antibiotics or diuretics) may enhance the risk of sunburn.
• Cosmetic Products: Avoid using abrasive soaps, cleansers, or skincare products that dry or irritate the skin.
• Alcohol-Containing Products: Alcohol-based astringents and toners can exacerbate dryness and irritation when used with DAIVOBET.

Always inform your healthcare provider about all skincare products and medications you are using before starting treatment with DAIVOBET.

Dosage of DAIVOBET

Following the correct dosage instructions is critical for safe and effective treatment:

• Adults and Adolescents (≥12 years): Apply a thin film to the affected area once daily at bedtime.
• Missed Dose: If a dose is missed, apply as soon as remembered. Skip if it’s near the next dose time. Do not double the application.
• Adjustment: Dosage may be reduced (e.g., every other night) if excessive irritation occurs.
• Duration: Continued use for 8-12 weeks is typically required for significant clinical improvement.

Patients should not self-adjust dosing without consulting a healthcare provider to avoid worsening of side effects.

Possible side effects of DAIVOBET

While DAIVOBET is generally safe, some patients may experience the following side effects:

• Very Common (≥10%): Redness, dryness, scaling, stinging, or burning at the application site.
• Common (1%-10%): Irritation, pruritus (itching), skin discomfort, and peeling.
• Less Common (<1%): Sun sensitivity, rash, or worsening of acne initially (known as "purging").
• Rare: Severe allergic reactions including swelling, difficulty breathing (medical emergency).

Symptoms often decrease with continued use. Moisturizers and a gentle skincare regimen can help alleviate irritation.

DAIVOBET Contraindications DAIVOBET

DAIVOBET should not be used under the following conditions:

• Hypersensitivity: Known allergy to Adapalene or any component of the ointment.
• Pregnancy: Contraindicated due to potential teratogenic effects; alternative acne treatments are recommended.
• Breastfeeding: Caution is advised, especially when applying near the chest area.
• Damaged Skin: Avoid use on cuts, abrasions, eczematous, or sunburned skin.
• Severe Skin Conditions: Should not be used in patients with severe eczema or other chronic inflammatory dermatoses unless directed by a healthcare provider.

Medical evaluation is essential before initiating treatment with DAIVOBET to rule out contraindications.

Storage of DAIVOBET

Correct storage preserves the efficacy and stability of DAIVOBET:

• Temperature: Store at 20°C to 25°C (68°F to 77°F). Allowable excursions between 15°C and 30°C.
• Protection: Keep the tube tightly closed and protect it from light and moisture.
• Handling: Do not freeze the ointment. Avoid exposing the product to extreme heat.
• Shelf Life: Check the expiration date printed on the packaging. Do not use after expiration.
• Safety: Keep out of the reach of children and pets to avoid accidental ingestion or misuse.

Following these guidelines ensures that DAIVOBET remains safe and effective throughout its intended shelf life.