DELTACEF 1g Powder for Solution for Injection or Infusion

What is DELTACEF 1g

DELTACEF 1g contains Cefepime, a fourth-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It is commonly used to treat severe infections caused by Gram-positive and Gram-negative bacteria, including respiratory tract infections, urinary tract infections, skin infections, and sepsis. Cefepime works by inhibiting bacterial cell wall synthesis, which leads to the destruction of the bacteria.

This medication is administered through injection or infusion, making it ideal for use in hospital settings for serious infections that require rapid and potent antibiotic intervention. DELTACEF is typically reserved for infections that are resistant to less potent antibiotics, and its broad-spectrum action makes it effective against a variety of difficult-to-treat pathogens.

DELTACEF is supplied as a powder in a 1g glass vial, which needs to be reconstituted with an appropriate solution before administration. This medication is usually administered by healthcare professionals in a clinical setting.

How to use DELTACEF 1g

DELTACEF 1g is administered either through intravenous (IV) infusion or intramuscular (IM) injection. The route of administration and the dosage will depend on the type and severity of the infection being treated. Follow these guidelines for proper use:

• Preparation: The powder must be reconstituted with a compatible solution, such as sterile water for injection or 0.9% sodium chloride solution, by a healthcare provider before administration.
• Intravenous Infusion: For IV infusion, the reconstituted solution is further diluted and infused over 30 minutes to 1 hour.
• Intramuscular Injection: For IM injection, the reconstituted solution is injected deep into a large muscle, such as the gluteus.
• Monitoring: Patients receiving DELTACEF should be monitored for allergic reactions or side effects during and after administration.

It is crucial to follow the dosing schedule prescribed by the healthcare provider. Do not skip doses or stop treatment prematurely, as this can lead to incomplete treatment of the infection and the development of antibiotic-resistant bacteria.

Mode of Action DELTACEF 1g

Cefepime, the active ingredient in DELTACEF 1g, is a broad-spectrum antibiotic that belongs to the cephalosporin class. It works by binding to specific penicillin-binding proteins (PBPs) in bacterial cell walls, leading to the inhibition of cell wall synthesis. Without a functional cell wall, bacteria cannot survive, leading to their destruction.

Cefepime is particularly effective against both Gram-positive and Gram-negative bacteria, including resistant strains such as Pseudomonas aeruginosa and Enterobacter species. Its broad spectrum of activity makes it a valuable option for treating severe, hospital-acquired infections or infections in patients with compromised immune systems.

• Bactericidal Action: Cefepime’s ability to destroy bacteria by inhibiting cell wall synthesis provides rapid relief from infections.
• Broad Spectrum: The drug is effective against a wide range of bacterial pathogens, making it useful in treating mixed infections or infections of unknown origin.

Because Cefepime is highly potent, it is generally reserved for serious bacterial infections and is often used when other antibiotics have failed or are not appropriate.

DELTACEF 1g Interactions DELTACEF 1g

DELTACEF 1g (Cefepime) can interact with other medications, potentially altering its effectiveness or increasing the risk of side effects. Some interactions to be aware of include:

• Aminoglycosides: Co-administration of Cefepime with aminoglycoside antibiotics may increase the risk of nephrotoxicity (kidney damage). Regular monitoring of kidney function is recommended.
• Diuretics: Loop diuretics like furosemide can increase the risk of kidney damage when used alongside Cefepime. Caution should be exercised when using these medications together.
• Probenecid: This medication can decrease the renal excretion of Cefepime, leading to higher concentrations of the drug in the blood and potentially increasing the risk of side effects.
• Live Vaccines: Cefepime may reduce the effectiveness of certain live bacterial vaccines, such as the typhoid vaccine. It is recommended to avoid live vaccines during treatment.

It is essential to inform your healthcare provider of all medications you are taking, including prescription, over-the-counter drugs, and supplements, to avoid harmful interactions.

Dosage of DELTACEF 1g

The dosage of DELTACEF 1g depends on the type and severity of the infection, the patient’s age, and kidney function. Common dosing recommendations include:

• Adults: For most infections, 1g to 2g of Cefepime is administered every 12 hours, either through IV or IM. For severe infections, such as febrile neutropenia, the dose may be increased to 2g every 8 hours.
• Children: The pediatric dose is typically based on body weight, with 50 mg/kg administered every 12 hours. Doses may be adjusted for severe infections or patients with impaired kidney function.
• Kidney Impairment: In patients with reduced kidney function, the dosage or frequency of administration should be adjusted to prevent accumulation of the drug and minimize the risk of toxicity.

Always follow the dosing instructions provided by your healthcare provider. Do not skip doses, and complete the full course of treatment even if you start to feel better.

Possible side effects of DELTACEF 1g

As with all medications, DELTACEF 1g (Cefepime) may cause side effects, though not everyone will experience them. Common side effects include:

• Local pain, redness, or swelling at the injection site
• Nausea, vomiting, or diarrhea
• Headache
• Rash or allergic reactions

Serious side effects are rare but may include:

• Severe allergic reactions (anaphylaxis)
• Clostridium difficile-associated diarrhea, which can occur after antibiotic use
• Kidney dysfunction, particularly in patients receiving high doses or with pre-existing kidney conditions
• Seizures, especially in patients with kidney problems or those receiving high doses of Cefepime

If you experience severe side effects, such as difficulty breathing, severe diarrhea, or signs of an allergic reaction, seek immediate medical attention.

DELTACEF 1g Contraindications DELTACEF 1g

Information not available.

Storage of DELTACEF 1g

Store DELTACEF 1g vials at room temperature, between 20°C and 25°C (68°F and 77°F). Keep the vials in their original packaging until use to protect them from light and moisture. Once the powder is reconstituted, the solution should be used immediately or stored in a refrigerator and used within a specified time frame, as indicated by the healthcare provider.

• Do not freeze the reconstituted solution.
• Keep the medication out of reach of children and pets.

Always follow the storage instructions provided by your healthcare provider or pharmacist. Dispose of any unused or expired medication properly, according to local regulations.