DELTACEF 2g Powder for Solution for Injection or Infusion

What is DELTACEF 2g

DELTACEF 2g is a broad-spectrum antibiotic that contains the active ingredient Cefepime, a fourth-generation cephalosporin. It is primarily used to treat severe bacterial infections such as pneumonia, urinary tract infections (UTIs), skin infections, and intra-abdominal infections. It is also effective against neutropenic fever, a condition commonly seen in cancer patients undergoing chemotherapy. As a powder for solution, DELTACEF 2g is administered either through injection or infusion under medical supervision, typically in a hospital setting.

Cefepime works by inhibiting bacterial cell wall synthesis, which leads to the destruction of the bacteria. This antibiotic is particularly effective against a wide range of gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa, which is often resistant to other antibiotics. DELTACEF 2g is especially useful in treating complicated infections where other antibiotics have failed or where drug resistance is suspected.

DELTACEF 2g is available in powder form, which must be reconstituted by a healthcare professional before administration. The powder is dissolved in sterile water or a suitable diluent to prepare the solution for injection or infusion. The choice between intravenous (IV) injection or infusion depends on the severity of the infection and the patient’s overall health condition.

How to use DELTACEF 2g

How to use DELTACEF 2g:

• DELTACEF 2g is administered by a healthcare professional through intravenous injection or infusion. It is not intended for self-administration.
• The powder must be dissolved in sterile water, saline, or another approved diluent before use. This process, known as reconstitution, should be performed by a trained healthcare provider under sterile conditions.
• Once reconstituted, the solution should be used immediately or stored according to the manufacturer’s instructions if not used right away.
• The dosage and frequency of administration are determined by the treating physician, based on the type of infection, its severity, and the patients overall health, including kidney function.
• For intravenous injection, the solution is administered over 30 minutes to 1 hour. In cases of severe infection, an infusion may be used for prolonged treatment.
• If a dose is missed, it should be administered as soon as possible under medical supervision, without doubling up on doses.

Always follow your healthcare provider’s instructions regarding the dosage and duration of treatment. Completing the full course of antibiotics is crucial to ensure the infection is fully eradicated and to reduce the risk of resistance.

Mode of Action DELTACEF 2g

Mode of action of DELTACEF 2g:

Cefepime, the active ingredient in DELTACEF 2g, is a fourth-generation cephalosporin antibiotic that works by disrupting the synthesis of the bacterial cell wall. This leads to bacterial cell death, effectively treating the infection. Cefepime is unique in its broad-spectrum activity, making it effective against both gram-positive and gram-negative bacteria. It has a higher affinity for penicillin-binding proteins (PBPs), which are critical for cell wall formation in bacteria.

The bactericidal activity of Cefepime extends to many drug-resistant strains, including certain strains of Pseudomonas aeruginosa and Enterobacteriaceae. This makes DELTACEF 2g an essential option in treating infections caused by multi-drug resistant organisms (MDROs).

• Inhibition of cell wall synthesis: Cefepime binds to specific PBPs located on the bacterial cell wall. This binding inhibits the final stage of cell wall synthesis, leading to the rupture of the bacterial cell.
• Broad-spectrum activity: Cefepime is effective against a wide range of pathogens, including Streptococcus pneumoniae, Escherichia coli, and Klebsiella pneumoniae, as well as many gram-negative bacteria that are resistant to other antibiotics.

By targeting bacterial cell walls, DELTACEF 2g disrupts critical life processes in the bacteria, making it a powerful weapon against serious infections.

DELTACEF 2g Interactions DELTACEF 2g

Drug interactions with DELTACEF 2g:

• Aminoglycosides: Combining Cefepime with aminoglycoside antibiotics can increase the risk of nephrotoxicity (kidney damage). Monitoring of kidney function is essential if these drugs are used together.
• Loop diuretics: Using DELTACEF 2g with loop diuretics (e.g., furosemide) may enhance the risk of kidney toxicity. Careful monitoring is recommended when these drugs are co-administered.
• Probenecid: Probenecid can slow the renal excretion of Cefepime, leading to increased blood levels of the antibiotic. This may require dose adjustments to avoid toxicity.
• Vaccines: The effectiveness of certain live vaccines, such as the BCG vaccine for tuberculosis or typhoid vaccine, may be reduced when administered with antibiotics like Cefepime. Avoid vaccination during treatment with DELTACEF unless advised otherwise by your healthcare provider.

Always inform your doctor about all medications, supplements, and herbal products you are taking before starting treatment with DELTACEF 2g. This will help to avoid potential drug interactions that may affect your treatment.

Dosage of DELTACEF 2g

Dosage of DELTACEF 2g:

The dosage of DELTACEF 2g is determined by the type and severity of the infection being treated, as well as the patient’s kidney function. The typical dosage for adults ranges from 1 to 2 grams of Cefepime administered every 8 to 12 hours by intravenous injection or infusion. For life-threatening infections, higher doses may be required.

• Adult dosage: For moderate to severe infections, the recommended dose is 1 to 2 grams every 8 to 12 hours. For severe infections such as sepsis or pneumonia, higher doses may be administered.
• Renal impairment: In patients with renal impairment, the dose must be adjusted based on creatinine clearance. This helps to avoid excessive drug accumulation, which could lead to toxicity.
• Children: DELTACEF 2g is not commonly used in pediatric patients, but if required, the dosage is based on body weight and the type of infection.

Dosage adjustments are crucial for patients with compromised kidney function. Your healthcare provider will monitor your kidney function through blood tests and adjust the dose accordingly. Do not adjust the dose on your own or stop the medication without medical guidance.

Possible side effects of DELTACEF 2g

Possible side effects of DELTACEF 2g:

Like all medications, DELTACEF 2g can cause side effects, although not everyone will experience them. Most side effects are mild and resolve after treatment ends, but serious side effects can occur in some cases.

• Common side effects: These may include nausea, vomiting, diarrhea, and local irritation at the injection site. These side effects are generally mild and temporary.
• Serious side effects: Serious reactions, though rare, can include allergic reactions (rash, swelling, difficulty breathing), seizures (especially in patients with kidney dysfunction), and Clostridium difficile-associated diarrhea, which can occur during or after treatment.
• Nephrotoxicity: In rare cases, Cefepime can cause kidney damage, particularly when combined with other nephrotoxic drugs such as aminoglycosides or diuretics.
• Blood disorders: Cefepime may cause changes in blood counts, including low white blood cells (leukopenia) and platelets (thrombocytopenia). Monitoring of blood counts may be required during long-term treatment.

If you experience severe or persistent side effects, seek medical attention immediately. It is important to inform your healthcare provider about any side effects you experience during treatment with DELTACEF 2g.

DELTACEF 2g Contraindications DELTACEF 2g

Information not available.

Storage of DELTACEF 2g

Storage instructions for DELTACEF 2g:

• Store DELTACEF 2g powder in its original glass vial at room temperature (15°C to 25°C).
• Once reconstituted, the solution should be used immediately or stored according to the manufacturer’s instructions for a short period. Do not freeze the reconstituted solution.
• Keep the vial tightly sealed when not in use and out of the reach of children.
• Do not use the medication after the expiration date printed on the packaging.
• Dispose of any unused or expired medication following local regulations for medical waste disposal.

Proper storage ensures the medication’s potency and safety. If you have any questions regarding the storage or disposal of DELTACEF 2g, consult your healthcare provider or pharmacist.