HEMADID 200 mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Dried Ferrous Sulphateis available in the market in concentration

Name

Human Albumin

Precaution

Before receiving **Human Albumin**, patients should always consult with their healthcare provider to ensure its suitability. Key precautions include: - **Allergy**: Although rare, some individuals may have an allergic reaction to **Human Albumin**. If a patient has known allergies to human proteins, they should inform their healthcare provider. - **Cardiovascular Disease**: **Human Albumin** may cause **fluid overload**, especially in patients with **heart failure**, **renal failure**, or **pre-existing cardiovascular conditions**. Close monitoring is necessary for these patients, and the dosage may need adjustment. - **Renal Impairment**: In patients with **severe renal disease**, the administration of albumin must be carefully monitored, as it may exacerbate **fluid retention**. - **Coagulation Disorders**: Albumin should be used with caution in patients with **severe bleeding disorders** or those who are receiving anticoagulant therapy. - **Pregnancy**: The **Human Albumin** preparation is typically considered safe for use during pregnancy, but the benefits should always be weighed against potential risks. It is recommended to consult a healthcare provider before use during pregnancy. - **Children**: While **Human Albumin** can be used in pediatric patients, particularly for **neonates** and **infants**, the dosing and administration require careful monitoring due to the increased risk of **fluid overload**.

Indication

**Human Albumin** is used to restore or maintain **blood volume** and **protein levels** in patients suffering from conditions such as: - **Hypovolemia**: The replacement of lost fluids during **shock** (due to trauma, burns, surgery, or major hemorrhage) can be achieved with **Human Albumin** to improve blood pressure and volume. - **Neonatal Conditions**: **Human Albumin** is used in neonates, particularly in the treatment of **hypoalbuminemia** (low levels of albumin in the blood) and conditions like **neonatal sepsis**. - **Liver Disease**: It is commonly used in the management of **cirrhosis**, particularly in the treatment of **ascites** (fluid buildup in the abdomen) and **hepatorenal syndrome** (kidney failure associated with liver disease). - **Burns**: After **severe burns**, **Human Albumin** can be administered to restore protein levels and prevent fluid loss. - **Kidney Disease**: Used to treat patients with **nephrotic syndrome**, in which there is a significant loss of **albumin** in the urine leading to low plasma protein levels. - **Acute Respiratory Distress Syndrome (ARDS)**: In some cases, **Human Albumin** is used to maintain oncotic pressure and treat **acute respiratory distress syndrome** when complications from infection or injury lead to fluid shifts in the body.

Contra indication

**Human Albumin** should be avoided in the following situations: - **Hypersensitivity to Albumin**: Individuals who have a history of **severe allergic reactions** to human albumin should not receive this product. - **Hypervolemia**: Patients with **fluid overload** conditions, including those with **severe heart failure**, **pulmonary edema**, or **chronic kidney disease**, should not receive **Human Albumin** without careful monitoring, as it may exacerbate these conditions. - **Severe Anemia**: In patients with significant **anemia** (a condition in which the blood lacks sufficient red blood cells), the use of **Human Albumin** may not be appropriate unless there is a concurrent need for volume expansion.

Side Effect

Although **Human Albumin** is generally well tolerated, it can cause some side effects, including: - **Allergic Reactions**: Mild symptoms may include **rash**, **urticaria** (hives), or **itching**. More severe allergic reactions, like **anaphylaxis**, are rare but can occur. - **Fluid Overload**: The most common side effect is **fluid overload**, which can lead to **pulmonary edema**, **dyspnea** (difficulty breathing), or **heart failure**. Monitoring of **fluid balance** and **cardiac status** is crucial. - **Hypotension**: Although less common, the administration of **Human Albumin** may lead to a drop in **blood pressure** in some patients. - **Fever**: Some patients may experience a mild fever after the infusion. - **Headache**: Mild to moderate headache can occur in some individuals. - **Nausea and Vomiting**: Gastrointestinal symptoms like nausea and vomiting can be associated with the infusion.

Pregnancy Category ID

3

Mode of Action

**Human Albumin** is a **protein solution** derived from human blood plasma. It primarily serves to **increase oncotic pressure**, which helps to retain fluid within the blood vessels and maintain proper fluid balance in the body. Its mechanism of action includes: - **Restoration of Plasma Volume**: By increasing **oncotic pressure**, **Human Albumin** helps restore **blood volume**, which is vital in conditions like **hypovolemia** due to blood loss or fluid shifts. - **Transport of Molecules**: Albumin plays a critical role in the transport of various molecules such as **fatty acids**, **hormones**, **drugs**, and **bilirubin**. - **Maintaining Osmotic Pressure**: The main function of albumin in the body is to maintain **osmotic pressure**, preventing excessive leakage of fluids from the blood vessels into the surrounding tissues.

Interaction

There are no major known drug interactions with **Human Albumin**, but it’s important to be aware of the following: - **Diuretics**: When **Human Albumin** is administered alongside **diuretics** (such as **furosemide**), it can lead to more profound diuresis (fluid loss). This combination should be monitored carefully. - **Anticoagulants**: **Human Albumin** can affect the **viscosity** of blood, potentially altering the effectiveness of anticoagulants like **heparin** and **warfarin**. Regular blood coagulation tests are recommended. - **Corticosteroids**: When combined with **steroid therapy**, the use of **albumin** may increase fluid retention and aggravate conditions such as **heart failure** or **hypertension**.

Pregnancy Category Note

Information not available

Adult Dose

The **adult dose** of **Human Albumin** depends on the specific indication and patient condition. Typical dosing recommendations include: - **Hypovolemia or Shock**: **Human Albumin** is typically administered as a **5% or 25% solution**. The usual dose for **acute volume replacement** is between **500-1000 mL**, depending on the severity of the condition and patient weight. The dose can be repeated depending on the patient’s fluid status. - **Liver Disease (Ascites)**: **Human Albumin** may be used to treat **ascites** in liver cirrhosis. A typical dose ranges from **50-100 g** daily, depending on the severity of the condition. - **Neonatal**: For infants with **hypoalbuminemia**, doses typically range from **0.5 to 1.0 g/kg body weight**.

Child Dose

For pediatric patients, particularly **neonates**, **Human Albumin** dosing is based on **body weight** and the clinical indication: - **Neonatal Hypoalbuminemia**: The usual dose is typically around **0.5-1.0 g/kg** of body weight, administered as a slow intravenous infusion. - **Burns**: For pediatric patients with **severe burns**, the dose will depend on the extent of the burn injury, and volumes of up to **10-20 mL/kg** may be given initially, with subsequent doses depending on the fluid needs. - **Nephrotic Syndrome**: Children with **nephrotic syndrome** may require doses between **1-2 g/kg** body weight. It is important to adjust doses based on clinical evaluation, and always under the guidance of a healthcare provider. ---

Renal Dose

In patients with **renal impairment**, the dose of **Human Albumin** may need to be adjusted. However, renal failure does not significantly alter the dosage schedule of **Human Albumin** itself. Careful monitoring is essential to avoid **fluid overload**, especially in patients with **end-stage renal disease**. The goal is to balance **fluid replacement** with the patient's ability to excrete excess fluid.

Administration

Information not available