PANDERM Ointment

What is PANDERM

PANDERM Ointment is a topical combination medication designed to treat skin conditions involving mixed bacterial and fungal infections accompanied by inflammation. It is formulated with four active ingredients: Gramicidin, Neomycin (as sulphate), Nystatin, and Triamcinolone acetonide. This multipurpose ointment offers broad-spectrum antimicrobial action along with potent anti-inflammatory properties.

• Generic Components:
• Gramicidin: A polypeptide antibiotic effective against Gram-positive bacteria
• Neomycin sulphate: An aminoglycoside antibiotic with broad-spectrum antibacterial activity
• Nystatin: An antifungal agent active against Candida species
• Triamcinolone acetonide: A medium-potency corticosteroid that reduces inflammation, redness, and itching
• Form: Ointment, ideal for dry or scaly skin lesions
• Size: 15g collapsible tube
• Uses:
• Dermatitis with secondary infection
• Candidal intertrigo
• Bacterial-fungal mixed infections
• Inflammatory skin disorders with microbial involvement

This ointment is particularly beneficial for chronic or dry skin lesions due to its occlusive and moisturizing base, enhancing absorption and healing.

How to use PANDERM

PANDERM Ointment is intended for external use only and should be applied according to your doctor’s instructions. Proper application is essential for optimal effectiveness and minimizing the risk of adverse reactions.

• Preparation:
• Wash hands before and after applying the ointment
• Gently cleanse and dry the affected area
• Application:
• Apply a thin layer of the ointment directly to the affected area
• Rub in gently until it is evenly distributed over the lesion
• Do not use bandages or occlusive dressings unless advised by a healthcare provider
• Frequency: Typically applied 2–3 times daily or as prescribed
• Important Notes:
• Avoid contact with eyes, mucous membranes, or open wounds
• Do not use on large areas of skin or for prolonged periods without medical supervision
• If irritation, burning, or worsening occurs, discontinue and consult a doctor

Follow-up with your healthcare provider is important, especially if symptoms persist beyond 7–10 days.

Mode of Action PANDERM

The therapeutic effectiveness of PANDERM Ointment comes from the synergistic action of its four active ingredients, each targeting a different aspect of skin infections and inflammation.

• Gramicidin: A peptide antibiotic that disrupts the integrity of Gram-positive bacterial membranes, causing cell death
• Neomycin sulphate: Inhibits bacterial protein synthesis by binding to ribosomal subunits, effective against Gram-negative and some Gram-positive organisms
• Nystatin: Binds to ergosterol in fungal membranes, leading to pore formation, leakage of cellular contents, and fungal cell death, particularly effective against Candida species
• Triamcinolone acetonide: A corticosteroid that suppresses the release of inflammatory cytokines, reducing redness, swelling, and itching

This combination ensures that PANDERM Ointment not only treats infections but also provides symptomatic relief from associated discomfort such as itching and inflammation.

PANDERM Interactions PANDERM

Although systemic absorption is generally minimal with topical products, interactions can occur, particularly with extensive or long-term use, or when applied to broken skin.

• Drug Interactions:
• Other topical antibiotics or antifungals – may increase skin irritation or allergic responses
• Topical corticosteroids – using additional steroids can increase the risk of side effects like skin thinning
• Ototoxic and nephrotoxic drugs – systemic absorption of neomycin can be enhanced with large area application, raising the risk of toxicity
• Vaccines – corticosteroids may reduce the immune response to live vaccines if absorbed systemically
• Precautions:
• Inform your healthcare provider of all medications and skin products in use
• Avoid combining with other skin treatments unless specifically directed
• Do not apply on broken or mucosal surfaces unless instructed

While rare, serious interactions may develop if the ointment is overused or misused. Monitor closely for adverse reactions when using alongside other medications.

Dosage of PANDERM

The dosage of PANDERM Ointment depends on the type and severity of the skin condition, and should always be guided by a medical professional.

• Typical Adult Dosage:
• Apply a thin layer to the affected skin area 2 to 3 times daily
• Treatment duration ranges from 7–14 days, depending on clinical response
• Special Populations:
• Children: Use cautiously under medical supervision, especially in infants
• Elderly: Use normal adult dosage, but monitor for increased skin sensitivity
• Pregnancy/Breastfeeding: Use only if prescribed, avoid application to breast or large areas
• Additional Guidelines:
• Do not exceed the recommended frequency or duration
• If symptoms persist beyond the recommended course, reevaluate with a doctor

Improper or prolonged use of corticosteroid-antibiotic combinations can result in side effects such as skin thinning, microbial resistance, or superinfection.

Possible side effects of PANDERM

Most patients tolerate PANDERM Ointment well when used as directed. However, side effects may occur, particularly with prolonged use or in individuals with sensitive skin.

• Common Side Effects:
• Skin irritation or burning at the application site
• Dryness, redness, or peeling
• Itching or rash
• Less Common / Serious Side Effects:
• Skin atrophy (thinning)
• Stretch marks (striae)
• Telangiectasia (visible small blood vessels)
• Secondary infections from prolonged corticosteroid use
• Systemic effects (e.g., adrenal suppression) if absorbed in large amounts
• Allergic Reactions: Hives, swelling, or breathing difficulty require immediate discontinuation and medical attention

Monitor the skin regularly during treatment. Report any unusual changes or lack of improvement to your healthcare provider.

PANDERM Contraindications PANDERM

There are specific situations where PANDERM Ointment should not be used due to the risk of aggravating the condition or causing harm.

• Absolute Contraindications:
• Hypersensitivity to any of the components (Gramicidin, Neomycin, Nystatin, or Triamcinolone)
• Viral skin infections (e.g., herpes simplex, varicella)
• Tuberculous or syphilitic skin lesions
• Ulcerated or weeping wounds
• Relative Contraindications / Precautions:
• Children under 2 years old – increased systemic absorption risk
• Use over large body areas – raises potential for systemic corticosteroid effects
• Pregnancy and lactation – use only if clearly indicated

Always seek medical advice before starting treatment, especially if you have underlying skin or immune conditions, or are taking other medications.

Storage of PANDERM

To ensure PANDERM Ointment maintains its effectiveness and safety, proper storage is essential.

• Storage Conditions: Store at temperatures below 25°C (77°F)
• Protection: Keep the tube tightly closed and away from direct sunlight, heat, and moisture
• Shelf-life: Do not use after the expiry date mentioned on the packaging
• Disposal:
• Do not flush or pour down the drain
• Dispose of through a pharmacy or follow local regulations
• Child Safety: Keep out of reach of children and pets

Check for any changes in the ointment's color, texture, or smell before each use. Discard if any abnormalities are observed.