PANDERM Cream

What is PANDERM

PANDERM Cream is a topical dermatological medication formulated with a combination of four active ingredients: Gramicidin, Neomycin (as sulphate), Nystatin, and Triamcinolone acetonide. It is indicated for the treatment of mixed bacterial and fungal skin infections that are also associated with inflammation and itching.

• Generic Ingredients:
• Gramicidin – an antibiotic effective against Gram-positive bacteria
• Neomycin sulphate – a broad-spectrum aminoglycoside antibiotic
• Nystatin – an antifungal agent used for candidiasis
• Triamcinolone acetonide – a corticosteroid that reduces inflammation and itching
• Form: Cream for topical application
• Packaging: 15g collapsible tube
• Indications:
• Fungal skin infections (e.g., candidiasis, ringworm)
• Bacterial superinfections
• Inflammatory dermatoses with secondary infection
• Mixed infections with associated itching, redness, or scaling

PANDERM Cream provides broad-spectrum antimicrobial activity alongside anti-inflammatory relief, making it useful in treating various skin infections where both fungi and bacteria are involved.

How to use PANDERM

PANDERM Cream should be used as directed by a healthcare professional. It is meant for **external use only** and should never be applied to open wounds or mucous membranes.

• Step-by-step Application:
• Clean the affected area gently with mild soap and water; pat dry
• Apply a thin layer of the cream to the affected area
• Rub it in gently until fully absorbed
• Wash hands immediately after application, unless hands are being treated
• Frequency of Use: Usually applied 2 to 3 times daily, depending on the severity and medical advice
• Important Tips:
• Do not cover with occlusive dressings unless directed by your physician
• Avoid contact with eyes, nose, mouth, and broken skin
• Do not use for longer than prescribed to avoid resistance or steroid-related side effects

If symptoms do not improve after 7 days or worsen, consult your doctor. Improper use can lead to treatment failure or complications such as skin thinning or secondary infections.

Mode of Action PANDERM

PANDERM Cream combines four active components that work synergistically to treat skin infections:

• Gramicidin: Disrupts bacterial cell membranes of Gram-positive organisms, leading to cell death.
• Neomycin (as sulphate): Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, effective against Gram-negative and some Gram-positive bacteria.
• Nystatin: Binds to ergosterol in fungal cell membranes, forming pores that lead to leakage and fungal cell death.
• Triamcinolone acetonide: A corticosteroid that reduces inflammation, swelling, redness, and itching by inhibiting multiple inflammatory cytokines and prostaglandin synthesis.

The unique combination in PANDERM Cream addresses both microbial infection and inflammatory symptoms, promoting healing while controlling pain, irritation, and infection simultaneously.

PANDERM Interactions PANDERM

Topical interactions are less common than systemic ones, but caution should still be exercised, especially if other topical or systemic treatments are in use.

• Potential Drug Interactions:
• Other topical antibiotics or antifungals – risk of additive irritation or hypersensitivity
• Topical corticosteroids – may lead to skin thinning or systemic absorption if used concurrently
• Ototoxic or nephrotoxic agents (when using large surface areas) – increased systemic absorption of neomycin may raise toxicity risk
• Live vaccines – topical corticosteroids may suppress immune response if absorbed systemically
• Precautionary Measures:
• Inform your healthcare provider about all current topical and oral medications
• Avoid using PANDERM Cream simultaneously with other skin treatments unless advised

While systemic absorption is minimal with topical use, it can become significant if used on large areas or broken skin, especially in infants or elderly individuals. Monitor for potential interactions and systemic side effects accordingly.

Dosage of PANDERM

The appropriate dosage of PANDERM Cream depends on the severity and extent of the skin condition. It should always be used as per a healthcare provider's direction.

• General Dosage Guidelines:
• Apply a thin layer to the affected area 2–3 times daily
• Use for 7–14 days depending on clinical response
• Do not use more than prescribed quantity to avoid adverse effects
• Maximum Duration: Avoid prolonged use (beyond 2 weeks) unless medically justified
• Pediatric Use: Use with caution and under medical supervision; thinner skin increases absorption risk
• Geriatric Use: Standard adult dosage applies, but monitor for systemic effects

Excessive application or long-term use may lead to corticosteroid side effects or antibiotic resistance. Always complete the full course even if symptoms improve early to ensure full eradication of infection.

Possible side effects of PANDERM

While PANDERM Cream is generally well-tolerated, especially for short-term use, side effects may occur due to either the corticosteroid or antimicrobial components.

• Common Side Effects:
• Skin irritation or burning sensation
• Dryness or redness at the site of application
• Peeling or itching
• Less Common but Serious Effects:
• Skin thinning (atrophy)
• Stretch marks or pigmentation changes
• Secondary bacterial or fungal infections due to immunosuppression
• Systemic absorption effects (adrenal suppression, especially in infants or with prolonged use)
• Allergic Reactions: Rash, swelling, or difficulty breathing – discontinue use and seek medical attention

If any adverse effect becomes severe or persistent, consult your doctor immediately. Discontinue the cream if allergic reactions or worsening of the infection occur.

PANDERM Contraindications PANDERM

PANDERM Cream should not be used in certain conditions where the ingredients may exacerbate the situation or cause harm.

• Absolute Contraindications:
• Known hypersensitivity to Gramicidin, Neomycin, Nystatin, or Triamcinolone
• Viral skin infections (e.g., herpes simplex, chickenpox)
• Tubercular or syphilitic skin lesions
• Open wounds or deep skin ulcers
• Relative Contraindications / Cautions:
• Pregnancy and breastfeeding – use only if clearly needed
• Prolonged use in children – increased systemic absorption risk
• Large surface area application – monitor for systemic corticosteroid side effects

Always consult a healthcare provider before starting treatment with PANDERM Cream, especially if there’s a history of allergic skin reactions, chronic conditions, or concurrent medication use.

Storage of PANDERM

Proper storage of PANDERM Cream is essential to maintain its stability and effectiveness. Follow the storage instructions on the packaging carefully.

• Storage Temperature: Store below 25°C
• Humidity and Light: Keep away from direct sunlight and moisture
• Container: Keep the tube tightly closed when not in use
• Children Safety: Store out of reach of children
• Disposal:
• Do not flush down the toilet or pour into drains
• Dispose of unused or expired cream through a pharmacy or as per local regulations

Do not use the cream after the expiry date printed on the packaging. Discard any cream that has changed color, consistency, or smell.