PANADOL EXTRA WITH OPTIZORB Tablets/Optizorb

What is PANADOL EXTRA WITH OPTIZORB

PANADOL EXTRA WITH OPTIZORB is a fast-acting analgesic and antipyretic formulation, designed to relieve moderate pain and reduce fever. It is a combination of two active ingredients: Paracetamol (500 mg) and Caffeine (65 mg), formulated with Optizorb technology for faster absorption.

• Paracetamol is a widely used analgesic and antipyretic agent known for its safety and efficacy when used as directed.
• Caffeine is a mild stimulant that enhances the analgesic effects of paracetamol, especially in the treatment of tension-type headaches and migraines.
• Optizorb technology contains superdisintegrants that help the tablet break down faster, allowing quicker absorption into the bloodstream.
• Available in a pack size of 24 tablets (two 12-tablet blisters), ideal for short-term use as needed.

Panadol Extra with Optizorb is commonly used for:

• Headaches and migraines
• Toothaches
• Back pain
• Muscle aches
• Dysmenorrhea (period pain)
• Fever and mild cold or flu symptoms

How to use PANADOL EXTRA WITH OPTIZORB

Proper usage of Panadol Extra with Optizorb ensures maximum benefit and reduces the risk of adverse effects. It should always be used in accordance with package instructions or as directed by a healthcare provider.

• Administration Route: Oral – Swallow tablets with water. Do not chew or crush.
• Timing: Can be taken with or without food. Taking it after meals may help reduce the chance of stomach discomfort due to caffeine.
• Onset of Action: Due to Optizorb technology, onset of relief may begin as quickly as 15–20 minutes.

Tips for optimal use:

• Do not exceed 8 tablets in 24 hours (maximum paracetamol dose: 4000 mg).
• Maintain a minimum interval of 4 hours between doses.
• Avoid other medications containing paracetamol to prevent overdose.
• Avoid caffeine-rich beverages (e.g., coffee, energy drinks) to reduce the risk of caffeine-related side effects.
• If pain or symptoms persist beyond a few days, consult your doctor rather than increasing the dosage.

Always read the patient information leaflet before using this medication.

Mode of Action PANADOL EXTRA WITH OPTIZORB

Panadol Extra with Optizorb combines two active substances working synergistically to provide enhanced pain relief and fever reduction.

• Paracetamol:
  • Works by inhibiting the enzyme cyclooxygenase (COX), primarily in the central nervous system.
  • This leads to decreased synthesis of prostaglandins—chemicals responsible for pain and fever.
  • Unlike NSAIDs, paracetamol does not have significant anti-inflammatory properties.
• Caffeine:
  • A central nervous system stimulant that blocks adenosine receptors, enhancing alertness and reducing fatigue.
  • Amplifies the analgesic effect of paracetamol, particularly beneficial for headache relief.
  • May also contribute mild vasoconstrictive effects, helpful in managing vascular headaches like migraines.
• Optizorb Technology:
  • Incorporates disintegrants such as alginic acid, calcium carbonate, and crospovidone.
  • Facilitates rapid tablet disintegration in the stomach, accelerating absorption into the bloodstream.

Overall, this combination offers quicker onset and enhanced efficacy compared to standard paracetamol formulations.

PANADOL EXTRA WITH OPTIZORB Interactions PANADOL EXTRA WITH OPTIZORB

It is important to be aware of potential drug interactions when using Panadol Extra with Optizorb, particularly due to its caffeine content and widespread use of paracetamol.

• Alcohol: Increases the risk of liver toxicity when used with paracetamol. Avoid concurrent use.
• Other Paracetamol-containing products: Risk of overdose. Do not use simultaneously.
• Warfarin and other anticoagulants:
  • Paracetamol may enhance the anticoagulant effect with prolonged use.
  • Monitor INR levels if long-term paracetamol use is necessary.
• MAO Inhibitors (e.g., phenelzine, tranylcypromine):
  • Caffeine may cause hypertensive crisis when taken with MAOIs.
  • Avoid concurrent use or allow a 14-day washout period after stopping MAOIs.
• Stimulants (e.g., pseudoephedrine, theophylline): Caffeine may increase stimulatory side effects such as jitteriness, tachycardia.
• Anticonvulsants (e.g., phenytoin, carbamazepine): May reduce paracetamol efficacy and increase hepatotoxicity risk.

Always inform your healthcare provider of any medications, supplements, or herbal products you are taking.

Dosage of PANADOL EXTRA WITH OPTIZORB

Dosage of PANADOL EXTRA WITH OPTIZORB

Correct dosing is critical to ensuring safety and effectiveness. Below are the general dosage guidelines:

• Adults and Children over 12 years:
  • Take 1–2 tablets every 4 to 6 hours as required.
  • Do not take more than 8 tablets in 24 hours.
• Children under 12 years: Not recommended due to caffeine content and dosage strength.
• Geriatric population: Use with caution; monitor liver function if using for extended periods.

Important Dosage Tips:

• Do not exceed the stated dose or frequency.
• Allow a minimum of 4 hours between doses.
• Consult a healthcare professional if pain persists beyond 3 days or if fever persists beyond 2 days.

In Case of Overdose: Immediate medical attention is essential due to the risk of severe liver damage. Symptoms may include nausea, vomiting, pallor, and abdominal pain.

Possible side effects of PANADOL EXTRA WITH OPTIZORB

Most individuals tolerate Panadol Extra with Optizorb well when used at the recommended dose. However, side effects can occur, especially with misuse or prolonged use.

• Common Side Effects:
  • Insomnia (due to caffeine)
  • Nervousness or restlessness
  • Gastrointestinal discomfort
• Uncommon/Rare Side Effects:
  • Allergic reactions (rash, itching, swelling)
  • Hepatotoxicity (especially with overdose or alcohol use)
  • Tachycardia or palpitations (from caffeine)
  • Thrombocytopenia or other blood disorders (rare)

Seek medical help immediately if you notice:

• Swelling of the face, lips, tongue, or throat (possible anaphylaxis)
• Yellowing of the skin or eyes (signs of liver impairment)
• Persistent nausea or vomiting

Discontinue use and consult your healthcare provider if any unusual symptoms occur.

PANADOL EXTRA WITH OPTIZORB Contraindications PANADOL EXTRA WITH OPTIZORB

Panadol Extra with Optizorb should not be used in certain individuals or conditions. Awareness of these contraindications helps prevent harm.

• Hypersensitivity: Known allergy to paracetamol, caffeine, or any excipients in the formulation.
• Severe hepatic impairment: Risk of life-threatening liver toxicity due to impaired paracetamol metabolism.
• Active peptic ulcer disease or GI bleeding: Caffeine can aggravate gastrointestinal irritation.
• Uncontrolled hypertension: Caffeine may exacerbate high blood pressure.
• Children under 12 years: Not recommended due to caffeine sensitivity and risk of overdose.
• Pregnancy and breastfeeding:
  • Should be used with caution. Consult a healthcare provider before use.
  • Caffeine crosses the placenta and is present in breast milk.

Always consult a physician before initiating therapy if you have pre-existing medical conditions or are on long-term medications.

Storage of PANADOL EXTRA WITH OPTIZORB

Proper storage ensures the medicine retains its potency and remains safe for consumption.

• Temperature: Store below 25°C (77°F). Avoid extreme heat or cold.
• Humidity: Keep in a dry place. Do not store in a bathroom or near a sink.
• Packaging: Keep in original blister pack until ready to use.
• Light: Protect from direct sunlight.
• Child Safety: Store out of reach and sight of children.

Disposal: Do not flush down toilets or pour into drains. Ask a pharmacist how to properly dispose of expired or unused medication.

Follow the expiration date on the package. Do not use the medicine beyond this date, even if it appears intact.