OXYNORM 10mg/ml Injection/Solution for

What is OXYNORM 10mg/ml

OXYNORM 10mg/ml is a potent opioid analgesic containing oxycodone hydrochloride. It is presented as a solution for injection, typically used for the management of moderate to severe pain in cases where other painkillers are inadequate. Each 1ml ampoule contains 10mg of oxycodone, designed for intravenous (IV), intramuscular (IM), or subcutaneous (SC) administration.

• Class: Strong opioid analgesic
• Indications: Acute post-operative pain, cancer-related pain, trauma, and palliative care
• Form: Injectable solution (ampoules), 1ml each
• Strength: 10mg of oxycodone per ml

This form allows rapid onset of pain relief, particularly useful in hospital settings or controlled environments where precise pain control is required.

How to use OXYNORM 10mg/ml

OXYNORM 10mg/ml should only be administered by a healthcare professional trained in the use of opioids. It can be administered via various routes depending on the clinical need:

• Intravenous injection (IV): Administer slowly over 2–3 minutes for rapid effect
• Intramuscular injection (IM): Useful when IV access is not available
• Subcutaneous injection (SC): Preferred for patients requiring regular doses in palliative care

Important Instructions:

• Do not self-administer; only trained healthcare providers should inject this medication
• Dose should be individualized based on pain severity, patient response, and prior opioid use
• Monitor respiratory status during administration, especially in opioid-naïve patients
• Always assess for signs of opioid misuse, dependency, or overdose

Mode of Action OXYNORM 10mg/ml

Oxycodone, the active substance in OXYNORM, is a semi-synthetic opioid agonist that binds selectively to the μ-opioid receptors in the central nervous system (CNS).

• μ-opioid receptor stimulation: Leads to inhibition of pain signal transmission
• Peripheral and central effects: Inhibits ascending pain pathways, alters perception of pain, and emotional response
• Rapid onset: Injectable form allows quicker analgesia compared to oral administration
• Duration of effect: Typically lasts 3–4 hours, depending on route of administration

Through this mechanism, OXYNORM effectively reduces both the sensation and emotional experience of pain, making it suitable for acute and breakthrough pain scenarios.

OXYNORM 10mg/ml Interactions OXYNORM 10mg/ml

Oxycodone has the potential to interact with several medications and substances, which can either potentiate its effects or increase the risk of adverse reactions:

• CNS depressants: Such as benzodiazepines, barbiturates, alcohol, antipsychotics – may enhance respiratory depression
• MAO inhibitors: Can cause severe or unpredictable interactions (avoid concurrent use)
• CYP3A4 inhibitors: Erythromycin, ketoconazole, ritonavir – may increase oxycodone plasma levels and toxicity
• CYP3A4 inducers: Rifampin, carbamazepine, phenytoin – may reduce oxycodone effectiveness
• Other opioids: Risk of overdose and increased adverse effects when used concurrently

Recommendation: Always review the patient's full medication list prior to initiating therapy to avoid harmful drug interactions.

Dosage of OXYNORM 10mg/ml

The dosage should be individualized based on the intensity of the pain, patient condition, and previous response to opioids. Initial doses are usually titrated under supervision:

• IV route: 1–2 mg every 5–10 minutes, titrated to pain relief; maximum 10mg/hour (adults)
• IM/SC route: 5–10 mg every 4 hours, adjusted as needed

Special considerations:

• Lower initial doses in elderly or opioid-naïve patients
• Adjustments required in hepatic or renal impairment
• Continuous infusion possible in palliative settings with dosage tailored to patient needs

Do not exceed prescribed doses. Regular review is essential to optimize pain control while minimizing risks.

Possible side effects of OXYNORM 10mg/ml

As with all opioids, oxycodone can cause a range of side effects, some of which may require medical attention:

• Very common: Constipation, nausea, drowsiness, dizziness
• Common: Vomiting, dry mouth, itching, sweating, headache
• Serious: Respiratory depression, hypotension, bradycardia
• Psychological: Euphoria, confusion, hallucinations in some individuals
• Dependence: Risk of physical or psychological dependence, especially with prolonged use

Monitoring and appropriate dose adjustment can reduce the risk of severe side effects. Report any unusual symptoms to the healthcare provider immediately.

OXYNORM 10mg/ml Contraindications OXYNORM 10mg/ml

OXYNORM should not be used in the following situations:

• Known hypersensitivity: To oxycodone or other opioid components
• Severe respiratory depression: In the absence of resuscitative equipment
• Paralytic ileus: Risk of worsening gastrointestinal paralysis
• Severe bronchial asthma: Particularly in unmonitored or poorly controlled patients
• Increased intracranial pressure: Or head injury where CO₂ retention may be dangerous

Relative contraindications include renal/hepatic impairment, hypothyroidism, or adrenal insufficiency. Always consult a specialist before initiating treatment in high-risk populations.

Storage of OXYNORM 10mg/ml

To maintain the effectiveness and safety of OXYNORM injections, proper storage is essential:

• Temperature: Store below 25°C (77°F). Avoid refrigeration unless specified by the manufacturer
• Light exposure: Protect ampoules from direct light – store in original packaging
• Keep away from moisture: Although sealed, ampoules should be kept dry
• Out of reach: Always keep out of reach of children or unauthorized individuals
• Expiry: Do not use after the expiry date indicated on the packaging

Dispose of unused or expired ampoules properly via pharmacy take-back programs or as directed by local regulations. Never flush or throw in household waste.