OSTEOMAX 200 mg Capsules (Hard Gelatin)

What is OSTEOMAX 200 mg

OSTEOMAX 200 mg is a prescription medication that contains the active ingredient Celecoxib, a non-steroidal anti-inflammatory drug (NSAID) specifically classified as a selective COX-2 inhibitor. It is formulated in hard gelatin capsule form and commonly used for the management of pain and inflammation associated with various musculoskeletal disorders.

• Generic Name: Celecoxib
• Strength: 200 mg per capsule
• Form: Hard gelatin capsules
• Pack Size: 28 capsules (14’s blister x 2)
• Drug Class: COX-2 selective NSAID

OSTEOMAX is primarily prescribed for conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute pain, including postoperative or menstrual pain. It is favored over traditional NSAIDs in patients who are at higher risk for gastrointestinal complications, due to its selective inhibition of COX-2, sparing COX-1 which protects the gastric lining.

How to use OSTEOMAX 200 mg

Proper usage of OSTEOMAX 200 mg is essential for maximizing its therapeutic effects while minimizing side effects.

• Administration: Take the capsule orally with a full glass of water. It can be taken with or without food, but taking it with food may reduce the risk of stomach upset.
• Do not crush or chew: Swallow the capsule whole. Crushing or chewing can alter the drug release profile.
• Consistency: Take the medication at the same time each day to maintain consistent blood levels.
• Missed Dose: If you miss a dose, take it as soon as you remember. If it's close to the next dose, skip the missed one. Do not double up.
• Hydration: Maintain adequate fluid intake during treatment unless otherwise advised by a healthcare provider.

Always follow your doctor's instructions exactly and do not change the dosage without medical advice. Long-term or high-dose use can increase the risk of cardiovascular events and should be closely monitored.

Mode of Action OSTEOMAX 200 mg

Celecoxib, the active component of OSTEOMAX 200 mg, works by selectively inhibiting the enzyme cyclooxygenase-2 (COX-2). This enzyme is involved in the synthesis of prostaglandins, which are chemical messengers responsible for inflammation and pain.

• COX-2 Inhibition: Celecoxib specifically blocks COX-2 activity, reducing prostaglandin production at sites of inflammation, pain, and swelling.
• Sparing COX-1: Unlike traditional NSAIDs, it spares COX-1, an enzyme that helps maintain the protective lining of the stomach and supports platelet function, reducing gastrointestinal side effects.
• Anti-inflammatory Effect: Decreases redness, swelling, and joint stiffness.
• Analgesic Effect: Relieves moderate pain from acute injuries or chronic conditions like arthritis.

This mechanism makes it especially useful in treating arthritis-related inflammation and pain without the GI complications typically associated with non-selective NSAIDs.

OSTEOMAX 200 mg Interactions OSTEOMAX 200 mg

OSTEOMAX (Celecoxib) can interact with a range of medications and substances, which may alter its effect or increase the risk of adverse reactions.

• Anticoagulants (e.g., Warfarin): Increases bleeding risk due to its effect on platelet function.
• ACE Inhibitors/ARBs: May reduce antihypertensive efficacy and increase risk of kidney damage.
• Diuretics: Can reduce the effectiveness of diuretics and contribute to kidney impairment.
• Other NSAIDs: Combining with ibuprofen, naproxen, or aspirin may heighten gastrointestinal and cardiovascular risks.
• Corticosteroids: Concurrent use raises the risk of GI ulcers and bleeding.
• Cytochrome P450 2C9 Inhibitors: Drugs like fluconazole may increase Celecoxib levels, heightening toxicity risk.

Always inform your healthcare provider about all medications, including over-the-counter drugs and herbal supplements, to avoid harmful interactions.

Dosage of OSTEOMAX 200 mg

The dosage of OSTEOMAX 200 mg should be individualized based on the condition being treated and patient response.

• Osteoarthritis: 200 mg once daily or 100 mg twice daily.
• Rheumatoid Arthritis: 100–200 mg twice daily depending on severity.
• Acute Pain or Primary Dysmenorrhea: 400 mg as a single dose on day one, followed by 200 mg if needed.
• Ankylosing Spondylitis: 200 mg once daily or 100 mg twice daily. Dose may be increased up to 400 mg/day if needed.

Note: The lowest effective dose for the shortest duration should be used to minimize risks. Dose adjustments may be needed in elderly patients or those with hepatic impairment.

Possible side effects of OSTEOMAX 200 mg

While OSTEOMAX 200 mg is generally well tolerated, it can cause side effects. These may be mild, moderate, or severe.

• Common Side Effects:
  • Dyspepsia (indigestion)
  • Abdominal pain
  • Headache
  • Nausea
  • Diarrhea
• Less Common:
  • Hypertension
  • Upper respiratory infections
  • Rash or itching
• Serious Adverse Effects:
  • Increased risk of cardiovascular events (e.g., heart attack, stroke)
  • Gastrointestinal bleeding or ulcers
  • Kidney function impairment
  • Liver dysfunction (elevated liver enzymes)
  • Severe allergic reactions (anaphylaxis)

Any persistent or serious symptoms should prompt immediate medical attention.

OSTEOMAX 200 mg Contraindications OSTEOMAX 200 mg

OSTEOMAX 200 mg is contraindicated in certain individuals due to the risk of serious complications.

• Known hypersensitivity: Allergy to celecoxib, sulfonamides, or any other NSAIDs.
• History of asthma, urticaria, or allergic-type reactions: Especially related to aspirin or other NSAIDs.
• Gastrointestinal bleeding or peptic ulcer disease: Active or history of.
• Severe hepatic impairment: Risk of drug accumulation and toxicity.
• Severe renal impairment: Can worsen renal function.
• Peri-operative pain in coronary artery bypass graft (CABG) surgery: Associated with increased risk of cardiovascular thrombotic events.

Patients with cardiovascular diseases, or risk factors for such diseases, should be assessed carefully before initiating treatment with celecoxib.

Storage of OSTEOMAX 200 mg

Proper storage of OSTEOMAX 200 mg ensures that the medicine remains effective and safe to use until its expiry.

• Temperature: Store at 20°C to 25°C (68°F to 77°F). Excursions permitted to 15°C to 30°C.
• Keep away from moisture and heat: Do not store in humid environments like bathrooms.
• Container: Keep in original blister packaging until use to protect from light and moisture.
• Keep out of reach of children: Accidental ingestion may cause serious health issues.
• Do not use after expiry date: Check the package for the expiration date and dispose of expired capsules properly.

Consult your pharmacist on how to properly dispose of unused or expired medication to prevent environmental contamination or accidental misuse.