ALGOXIB 200mg Capsules (Hard Gelatin)

What is ALGOXIB 200mg

ALGOXIB 200 mg is a prescription-only celecoxib capsule—a selective inhibitor of cyclooxygenase‑2 (COX‑2), part of the nonsteroidal anti-inflammatory drug (NSAID) family. Its hard gelatin capsules are commonly available in 20-count packs (typically 2 x 10 blister strips).

• Therapeutic class: Selective COX‑2 inhibitor (NSAID), designed to reduce inflammation and pain while minimizing gastrointestinal side effects of nonselective NSAIDs :contentReference[oaicite:1]{index=1}.
• Approved indications:
  • Osteoarthritis and rheumatoid arthritis
  • Ankylosing spondylitis
  • Acute pain, including dysmenorrhea and migraine attacks :contentReference[oaicite:2]{index=2}.
  • Juvenile rheumatoid arthritis (≥ 2 years old) :contentReference[oaicite:3]{index=3}.
• Key attributes: Provides faster pain relief—typically within one hour—and has fewer gastrointestinal effects compared with older NSAIDs due to COX‑2 selectivity :contentReference[oaicite:4]{index=4}.
• Limitations: While effective during administration, it does not cure underlying conditions and is associated with cardiovascular and gastrointestinal risks :contentReference[oaicite:5]{index=5}.

This makes ALGOXIB a valuable options for managing inflammation and pain with a targeted mechanism, yet its use requires careful patient evaluation due to its risk profile.

How to use ALGOXIB 200mg

Proper use of ALGOXIB ensures optimal efficacy and safety; it should only be taken under medical supervision.

• Administration: Swallow capsule whole with water; may be taken with or without food—note: high-fat meals may delay absorption moderately but don’t affect effectiveness :contentReference[oaicite:6]{index=6}.
• Dosing schedule: Typically given once or twice daily
  - Osteoarthritis: 200 mg once daily or 100 mg twice daily
  - Rheumatoid arthritis: 100–200 mg twice daily
  - Acute pain/dysmenorrhea: 400 mg once, followed by 200 mg if needed :contentReference[oaicite:7]{index=7}.
• Missed dose: Take as soon as remembered unless close to next scheduled dose; do not double dose :contentReference[oaicite:8]{index=8}.
• Duration: Use the lowest effective dose for the shortest time; prolonged use increases cardiovascular and GI risks :contentReference[oaicite:9]{index=9}.
• Monitoring: Routine checks of blood pressure, renal/hepatic function, and signs of GI bleeding (e.g., melena, epigastric pain) for long-term therapy :contentReference[oaicite:10]{index=10}.
• Patient cautions: Avoid combining with other NSAIDs; disclose all medications including OTC, herbals, and supplements :contentReference[oaicite:11]{index=11}.

Strict adherence to these guidelines maximizes benefit while guarding against adverse events.

Mode of Action ALGOXIB 200mg

ALGOXIB (celecoxib) provides targeted pain relief through selective COX‑2 inhibition:

• COX‑2 inhibition: Blocks cyclooxygenase‑2, an enzyme elevated during inflammation, which leads to decreased production of inflammatory prostaglandins :contentReference[oaicite:12]{index=12}.
• COX‑1 spared: Less impact on cyclooxygenase‑1, preserving gastric mucosal protection and platelet function, lowering GI bleeding risk :contentReference[oaicite:13]{index=13}.
• Onset and selectivity: Pain relief often within 1–2 hours; celecoxib is ~10–20× more selective for COX‑2 than COX‑1 :contentReference[oaicite:14]{index=14}.
• Additional activity: Research indicates possible anti-cancer benefits through COX‑2–mediated pathways like p53 apoptosis, although clinical evidence remains inconclusive :contentReference[oaicite:15]{index=15}.
• Pharmacokinetics: >97% protein binding; reaches peak blood levels 2–4 hours post dose; eliminated via hepatic CYP2C9 metabolism (half‑life ~6–12 hrs) :contentReference[oaicite:16]{index=16}.

This mechanism underlies its efficacy in inflammation-driven conditions, offering a pain relief option with reduced gastric impact compared to traditional NSAIDs.

ALGOXIB 200mg Interactions ALGOXIB 200mg

Celecoxib interacts with numerous drugs and substances. Always review with your healthcare provider before starting therapy.

• Other NSAIDs/aspirin: Avoid concurrent use—greatly increases GI bleeding and ulcer risk :contentReference[oaicite:17]{index=17}.
• Anticoagulants (e.g., warfarin, apixaban): Heightened bleeding risk—requires close monitoring :contentReference[oaicite:18]{index=18}.
• SSRIs/SNRIs: May exacerbate GI bleeding from additive effects :contentReference[oaicite:19]{index=19}.
• Lithium: Reduced clearance leads to increased lithium levels; monitor for toxicity :contentReference[oaicite:20]{index=20}.
• Methotrexate: Increased risk of bone marrow suppression—monitor CBC :contentReference[oaicite:21]{index=21}.
• ACE inhibitors/ARBs/diuretics: May blunt antihypertensive effects and increase renal risk :contentReference[oaicite:22]{index=22}.
• Cyclosporine: Elevated nephrotoxicity risk—monitor renal function :contentReference[oaicite:23]{index=23}.
• Digoxin: Celecoxib increases digoxin levels—monitor for toxicity :contentReference[oaicite:24]{index=24}.
• CYP2C9 inhibitors (e.g., fluconazole): Increase celecoxib blood levels; dosage adjustments may be necessary :contentReference[oaicite:25]{index=25}.
• Inducers (e.g., rifampin): May reduce efficacy by increasing metabolism :contentReference[oaicite:26]{index=26}.
• Herbs/supplements: Garlic, ginger, and Ginkgo may raise bleeding risk; potassium supplements could lead to hyperkalemia :contentReference[oaicite:27]{index=27}.
• Alcohol: Additive GI risk—limit intake :contentReference[oaicite:28]{index=28}.

Thorough medication review and monitoring (e.g., CBC, renal/hepatic panels, electrolytes) help minimize risks during celecoxib therapy.

Dosage of ALGOXIB 200mg

• Osteoarthritis: 200 mg once daily or 100 mg twice daily :contentReference[oaicite:29]{index=29}.
• Rheumatoid arthritis: 100–200 mg twice daily :contentReference[oaicite:30]{index=30}.
• Ankylosing spondylitis: 200 mg once or twice daily :contentReference[oaicite:31]{index=31}.
• Acute pain/dysmenorrhea: 400 mg initially, followed by 200 mg if needed :contentReference[oaicite:32]{index=32}.
• Juvenile RA: Weight-based dosing for ≥ 2 years—follow pediatric guidelines :contentReference[oaicite:33]{index=33}.
• Maximum dose: 400 mg/day. Exceeding increases serious risks :contentReference[oaicite:34]{index=34}.
• Special populations: In elderly or hepatic/renal impairment, start lower and monitor renal/hepatic and cardiovascular status :contentReference[oaicite:35]{index=35}.

Dosage decisions should always balance efficacy with patient-specific risk, using the lowest effective dose for the shortest period.

Possible side effects of ALGOXIB 200mg

Celecoxib is generally well tolerated, but adverse effects can range from mild to severe and require monitoring:

• Common, mild:
  • Abdominal pain, dyspepsia, gas, constipation, diarrhea, nausea/vomiting :contentReference[oaicite:36]{index=36}.
  • Headache, dizziness, upper respiratory symptoms :contentReference[oaicite:37]{index=37}.
• Cardiovascular risks:
  • Elevated BP, fluid retention, heart failure exacerbation, increased risk of MI or stroke—especially with long-term use :contentReference[oaicite:38]{index=38}.
• Gastrointestinal effects:
  • Ulcers, bleeding, or perforation—may occur without warning and can be fatal :contentReference[oaicite:39]{index=39}.
• Renal/hepatic issues:
  • Acute kidney injury, hyperkalemia, elevated liver enzymes/hepatitis in rare cases :contentReference[oaicite:40]{index=40}.
• Allergic/dermatologic:
  • Rash, pruritus, sulfa allergy reactions; rare severe skin reactions like Stevens–Johnson syndrome :contentReference[oaicite:41]{index=41}.
• Hematologic:
  • Anemia, unusual bleeding (especially with anticoagulants/SSRIs) :contentReference[oaicite:42]{index=42}.

Any serious or persistent symptoms should prompt immediate medical attention. Use the lowest effective dose and regularly monitor at-risk patients.

ALGOXIB 200mg Contraindications ALGOXIB 200mg

• Absolute:
  • Known allergy to celecoxib, sulfonamides, NSAIDs, aspirin, or history of asthma/urticaria induced by NSAIDs :contentReference[oaicite:43]{index=43}.
  • Use in periprocedural period of coronary artery bypass graft (CABG) surgery :contentReference[oaicite:44]{index=44}.
  • Active GI bleeding or ulcer disease :contentReference[oaicite:45]{index=45}.
  • Severe heart failure, uncontrolled hypertension :contentReference[oaicite:46]{index=46}.
  • Severe hepatic impairment (Child‑Pugh C) :contentReference[oaicite:47]{index=47}.
  • Pregnancy ≥ 20 weeks (risk for fetal ductus arteriosus closure) :contentReference[oaicite:48]{index=48}.
• Relative (caution advised):
  • History of cardiovascular disease, stroke, peripheral edema
  • Renal impairment or on nephrotoxic medications
  • Gastrointestinal risk factors (elderly, alcohol use, corticosteroid/anticoagulant therapy)
  • Asthma worsened by NSAIDs
  • Breastfeeding (weigh risks and benefits) :contentReference[oaicite:49]{index=49}.
• Pediatric: Only indicated for juvenile RA ≥ 2 years—other uses are off-label :contentReference[oaicite:50]{index=50}.

Storage of ALGOXIB 200mg

Proper storage preserves quality, safety, and efficacy:

• Temperature: Store between 20–25 °C (68–77 °F); avoid heat, humidity, and direct sunlight :contentReference[oaicite:51]{index=51}.
• Packaging: Keep capsules sealed in original blister packs, out of children’s reach.
• Disposal: Discard expired or damaged capsules; follow regulated medication disposal processes—do not flush :contentReference[oaicite:52]{index=52}.