ALGOXIB 200mg Capsules (Hard Gelatin)

What is ALGOXIB 200mg

ALGOXIB 200 mg is a prescription oral capsule formulation of **celecoxib**, a selective cyclooxygenase‑2 (**COX‑2**) inhibitor belonging to the nonsteroidal anti-inflammatory drug (**NSAID**) class. Designed to target pain and inflammation, it is available in hard gelatin capsules in a convenient blister pack of 10.

• Mechanism group: Selective COX‑2 inhibitor – reduces inflammation with lower risk of gastrointestinal side effects compared to nonselective NSAIDs :contentReference[oaicite:1]{index=1}.
• Indications:
  • Osteoarthritis (OA) and rheumatoid arthritis (RA) pain/inflammation :contentReference[oaicite:2]{index=2}
  • Ankylosing spondylitis and juvenile rheumatoid arthritis (age ≥ 2 years) :contentReference[oaicite:3]{index=3}
  • Acute pain, including menstruation (dysmenorrhea), migraines with aura :contentReference[oaicite:4]{index=4}
• Benefits: Provides effective pain relief and reduces swelling; works within ~1 hour of dosing :contentReference[oaicite:5]{index=5}.
• Limitations: Does not cure underlying disease; benefits last only while the drug is taken :contentReference[oaicite:6]{index=6}.

How to use ALGOXIB 200mg

Use ALGOXIB only under a healthcare provider's direction. Follow these general points:

• Administration: Swallow capsule whole with water; can be taken with or without food. A high-fat meal may delay absorption by ~1 hour but doesn't reduce efficacy :contentReference[oaicite:7]{index=7}.
• Frequency: Typically prescribed once or twice daily depending on condition severity; highest recommended dose: 400 mg/day divided doses :contentReference[oaicite:8]{index=8}.
• Missed dose: Take it when remembered unless next dose is due soon—do not double up :contentReference[oaicite:9]{index=9}.
• Duration: Use the lowest effective dose for the shortest time to manage symptoms; long-term use increases cardiovascular and gastrointestinal risks :contentReference[oaicite:10]{index=10}.
• Monitoring: Regularly evaluate blood pressure, kidney function, and signs of bleeding or edema during therapy :contentReference[oaicite:11]{index=11}.
• Patient advice: Always disclose concurrent medications—especially anticoagulants, ACE inhibitors, diuretics, SSRIs, fluconazole, lithium, or methotrexate due to potential interactions :contentReference[oaicite:12]{index=12}.

Mode of Action ALGOXIB 200mg

ALGOXIB acts via selective inhibition of COX‑2 enzyme:

• COX‑2 blockade: Prevents conversion of arachidonic acid into prostaglandin precursors—reducing inflammation and pain without significantly affecting COX‑1 pathways that protect gastric lining :contentReference[oaicite:13]{index=13}.
• Selectivity: Approximately 10–20 times more selective for COX‑2 than COX‑1, thus minimizing gastric side effects typical of older NSAIDs :contentReference[oaicite:14]{index=14}.
• Onset: Symptom relief usually begins within one hour of ingestion :contentReference[oaicite:15]{index=15}.
• Additional benefits: Some evidence suggests potential chemopreventive effects in colorectal adenomas due to COX‑2 inhibition in tumor pathways :contentReference[oaicite:16]{index=16}.

ALGOXIB 200mg Interactions ALGOXIB 200mg

Celecoxib interacts with several medications; always inform your doctor of all drugs and supplements you take.

• Other NSAIDs/aspirin: Combined use increases risk of ulcers and bleeding—avoid concurrent use :contentReference[oaicite:17]{index=17}.
• Anticoagulants (e.g., warfarin): May raise bleeding risk—enhance monitoring :contentReference[oaicite:18]{index=18}.
• SSRIs: Combined use may increase GI bleeding risk :contentReference[oaicite:19]{index=19}.
• Lithium: Celecoxib reduces lithium clearance, raising serum levels :contentReference[oaicite:20]{index=20}.
• Methotrexate: Risk of bone marrow suppression increases when used together :contentReference[oaicite:21]{index=21}.
• Digoxin: May elevate serum levels; monitor appropriately :contentReference[oaicite:22]{index=22}.
• Cyclosporine/ACE inhibitors/diuretics: May impair kidney function—monitor renal markers :contentReference[oaicite:23]{index=23}.
• Fluconazole (CYP2C9 inhibitor): May elevate celecoxib levels—dose adjustments recommended :contentReference[oaicite:24]{index=24}.
• Rifampin (inducer): May reduce drug levels—possibly decrease efficacy :contentReference[oaicite:25]{index=25}.

Dosage of ALGOXIB 200mg

• Osteoarthritis (OA): 200 mg once daily or 100 mg twice daily :contentReference[oaicite:26]{index=26}.
• Rheumatoid arthritis (RA): 100–200 mg twice daily :contentReference[oaicite:27]{index=27}.
• Ankylosing spondylitis: 200 mg once or twice daily :contentReference[oaicite:28]{index=28}.
• Acute pain/dysmenorrhea: 400 mg initially (single dose), then 200 mg if needed :contentReference[oaicite:29]{index=29}.
• Pediatric (≥2 years) juvenile RA: Weight-based dosing; consult pediatric guidelines :contentReference[oaicite:30]{index=30}.
• Max dose: 400 mg/day; prolonged use at higher doses increases serious risk :contentReference[oaicite:31]{index=31}.
• Special populations: Reduce dose in hepatic/renal impairment and elderly; monitor BP/renal function :contentReference[oaicite:32]{index=32}.
• Administration tips: Begin at symptom onset and reassess regularly; aim for minimal effective dose for shortest duration :contentReference[oaicite:33]{index=33}.

Possible side effects of ALGOXIB 200mg

Celecoxib is generally well tolerated, but side effects can range from mild to serious. Regular monitoring is essential:

• Common (mild): Abdominal pain, dyspepsia, nausea, diarrhea, gas, constipation, headache, dizziness, upper respiratory infection :contentReference[oaicite:34]{index=34}.
• Cardiovascular: Increased risk of hypertension, edema, heart failure exacerbation, heart attack, and stroke—especially in prolonged use :contentReference[oaicite:35]{index=35}.
• Gastrointestinal: Ulcers, bleeding, and perforation—though less frequent than nonselective NSAIDs, risk remains :contentReference[oaicite:36]{index=36}.
• Renal: Acute kidney injury, hyperkalemia, fluid retention :contentReference[oaicite:37]{index=37}.
• Hepatic: Rare cytolytic hepatitis or liver enzyme elevation :contentReference[oaicite:38]{index=38}.
• Allergic/skin reactions: Sulfonamide-related rash, urticaria, rarely severe reactions (Stevens–Johnson, anaphylaxis) :contentReference[oaicite:39]{index=39}.
• Hematologic: Anemia, unusual bleeding in combination with other hemorrhagic agents :contentReference[oaicite:40]{index=40}.
• Miscellaneous: Weight gain, sinusitis, upper respiratory symptoms :contentReference[oaicite:41]{index=41}.

Serious effects warrant immediate evaluation. Use the lowest effective dose, and monitor patients with pre-existing cardiovascular, GI, or renal risks closely.

ALGOXIB 200mg Contraindications ALGOXIB 200mg

• Absolute contraindications: History of allergy to celecoxib, aspirin, or sulfonamides; active GI bleeding or ulcers; severe heart failure; coronary artery bypass graft surgery; known coronary disease; severe hepatic impairment (Child-Pugh C); pregnancy ≥ 20 weeks due to fetal renal risk :contentReference[oaicite:42]{index=42}.
• Relative contraindications (caution):
  • Hypertension, heart failure, peripheral edema
  • Renal impairment or on ACE inhibitors/diuretics
  • Older adults (> 65 years): start with lower dose
  • Concurrent use of anticoagulants or SSRIs—close monitoring needed
• Pediatric use: Approved for juvenile RA from 2 years old; avoid off-label uses without specialist guidance :contentReference[oaicite:43]{index=43}.
• Pregnancy/breastfeeding: Avoid at ≥ 20 weeks gestation; limited data on nursing—risk/benefit counsel required :contentReference[oaicite:44]{index=44}.

Storage of ALGOXIB 200mg

• Temperature: Store at room temperature, between 20–25 °C; protect from heat and moisture :contentReference[oaicite:45]{index=45}.
• Packaging: Keep capsules in original, tightly closed blister packs away from children.
• Expiry: Discard expired capsules; do not use if blister is damaged or pills discolored.
• Disposal: Dispose unwanted medication via take‑back programs; do not flush down the toilet :contentReference[oaicite:46]{index=46}.