What is ALGOBAZ 10mg
ALGOBAZ 10 mg is an injectable preparation containing mecobalamin (also known as methylcobalamin), a coenzyme-active form of vitamin B₁₂. Offered as lyophilized powder in 10 vials, each requiring reconstitution with a solvent ampoule (2 mL), it is used primarily for treating vitamin B₁₂ deficiency and related neurological conditions.
- Vitamin class: Water-soluble B-complex vitamin, essential in DNA synthesis, red blood cell production, and neural function.
- Therapeutic uses:
- Treatment of megaloblastic or pernicious anemia caused by B₁₂ deficiency
- Support in peripheral neuropathy (e.g. diabetic, alcoholic, idiopathic types)
- Adjunctive therapy in neuralgias, such as post-herpetic or trigeminal neuralgia
- General neuroprotective and hematologic support in deficiency states
- Mechanism rationale: Mecobalamin bypasses conversion steps required for cyanocobalamin, entering metabolic pathways directly.
- Formulation advantages: Injectable route ensures reliable absorption—critical for patients with malabsorption or severe deficiency.
- Clinical acceptance: Widely prescribed in Asia, Europe, and other regions; recognized for high tolerability and safety :contentReference[oaicite:1]{index=1}.
How to use ALGOBAZ 10mg
Administration of ALGOBAZ must be done under medical supervision. Proper technique and asepsis are essential to ensure safety and effectiveness.
- Preparation:
- Inspect vials and solvent ampoules for damage or contamination.
- Reconstitute the lyophilized powder with the provided solvent (usually sterile water or saline).
- Gently swirl the vial until powder is fully dissolved; do not shake vigorously.
- Route and technique:
- Intramuscular (IM) injection is commonly used; intravenous (IV) also possible per protocol.
- Use an aseptic technique—clean injection site, change needles after drawing.
- Alternate injection sites to reduce tissue irritation.
- Frequency:
- Often administered daily to thrice weekly depending on severity and indication.
- Neuropathic conditions may require daily to every-other-day injections for weeks.
- Once hematologic improvement is seen, maintenance may shift to weekly or monthly dosing.
- Monitoring:
- Track clinical response—symptom resolution, hemoglobin, and B₁₂ serum levels.
- Observe for injection-site reactions or signs of hypersensitivity.
- Manage mild side effects with rest, analgesics, or hydration.
- Patient instructions:
- Avoid self-administration unless trained and capable.
- Inform provider about all concurrent medications or medical conditions.
- Report any persistent side effects, especially neurological or allergic symptoms.
Mode of Action ALGOBAZ 10mg
Mecobalamin serves as a biologically active form of vitamin B₁₂, integral to numerous biochemical processes—especially those involving the nervous system and hematopoiesis.
- Cofactor in methyl transfer:
- Allows conversion of homocysteine to methionine—crucial for the methylation of nucleic acids, proteins, and lipids.
- Supports synthesis of S-adenosylmethionine (SAMe), a key methyl donor in cellular metabolism.
- Myelin synthesis and nerve repair:
- Methionine and SAMe production supports methylation of myelin basic protein, critical to nerve insulation and conduction.
- Contributes to nerve regeneration in peripheral neuropathies by supporting DNA synthesis and cellular repair.
- Hematopoiesis support:
- Essential for red cell maturation; deficiency leads to megaloblastic anemia characterized by large, dysfunctional erythrocytes.
- Superior cellular bioavailability:
- As an active coenzyme form, it bypasses metabolic conversion, facilitating direct incorporation into enzymatic pathways.
By replenishing active B₁₂ stores, ALGOBAZ restores the biochemical pathways essential to neural health and red blood cell formation, improving symptoms of neuropathy, fatigue, and anemia :contentReference[oaicite:2]{index=2}.
ALGOBAZ 10mg Interactions ALGOBAZ 10mg
Although vitamin B₁₂ generally has low interaction risk, certain medications and conditions can affect mecobalamin’s absorption or efficacy.
- Metformin: May reduce B₁₂ absorption in chronic use; supplementation often required :contentReference[oaicite:3]{index=3}.
- Proton pump inhibitors (PPIs) / H₂-blockers: Long-term use reduces gastric acid and can impair B₁₂ assimilation :contentReference[oaicite:4]{index=4}.
- Chloramphenicol: Histidine suggests it can hinder B₁₂-dependent hematopoiesis :contentReference[oaicite:5]{index=5}.
- Colchicine, neomycin, aminosalicylates: Associated with reduced epithelial absorption of B₁₂ :contentReference[oaicite:6]{index=6}.
- Alcohol: Excessive intake impairs B₁₂ absorption and contributes to deficiency symptoms :contentReference[oaicite:7]{index=7}.
- Hypokalemia risk: Rapid hematologic improvement may trigger potassium shift, exacerbating low serum K⁺ :contentReference[oaicite:8]{index=8}.
- Anticancer agents (arsenic trioxide): Caution advised during combined use :contentReference[oaicite:9]{index=9}.
Disclosure of all medications and supplements is essential to optimize therapy and prevent suboptimal response or complications.
Dosage of ALGOBAZ 10mg
Dosing depends on the indication—ranging from deficiency correction to neuropathy management—and the patient’s clinical status.
- Typical adult dose:
- 500–1,500 µg IM or IV once to thrice weekly for 2–4 weeks;
- Adjust based on symptom resolution and laboratory parameters.
- Neuropathy management:
- 1,500 µg daily or every other day during acute neuropathic flare-ups;
- Maintenance dosing may reduce frequency to weekly once improvement is established.
- Anemia correction:
- As part of anemia regimen—usually daily to every-other-day until hematologic markers normalize;
- Followed by periodic maintenance injections (e.g., weekly or monthly).
- Special populations:
- Elderly, renal/hepatic impairment: Dosage frequency may be lower; monitoring required.
- Pediatrics: Usually 100–500 µg IM, frequency based on weight and severity.
- Transition to oral therapy: Once stable, oral or sublingual B₁₂ (e.g., 1,000 µg daily) may replace injections.
- Tapering and follow-up: Continue injections until deficiency markers normalize, then taper gradually. Monitor CBC and B₁₂ levels.
- Note: Dose conversion from powder: each vial contains 10 mg mecobalamin; after reconstitution volume must be calculated to deliver correct µg dose.
Possible side effects of ALGOBAZ 10mg
Injectable mecobalamin is well tolerated. Side effects are generally mild and transient, but monitoring is still important.
- Local injection-site reactions:
- Pain, redness, swelling, induration, or itching :contentReference[oaicite:10]{index=10}.
- Rare sterile abscess or granuloma; manage with local care or referral.
- Systemic effects:
- Gastrointestinal: Nausea, vomiting, diarrhea, anorexia :contentReference[oaicite:11]{index=11}.
- Neurological: Headache, mild dizziness :contentReference[oaicite:12]{index=12}.
- Allergic: Rare anaphylactoid reactions—hypotension, dyspnea—require immediate treatment :contentReference[oaicite:13]{index=13}.
- Metabolic shifts: Hypokalemia from rapid erythropoietic response; monitor electrolytes :contentReference[oaicite:14]{index=14}.
- Dermatologic effects: Rare rash or urticaria.
- Long-term issues: Very low risk; no addiction potential, little toxicity even at higher doses :contentReference[oaicite:15]{index=15}.
Advise patients to report unusual symptoms promptly. Mild effects often resolve without intervention; severe reactions may need symptomatic or emergency care.
ALGOBAZ 10mg Contraindications ALGOBAZ 10mg
While generally safe, certain conditions necessitate caution or avoidance.
- Absolute contraindications:
- Known hypersensitivity to mecobalamin, cobalt, or excipients :contentReference[oaicite:16]{index=16}.
- Anaphylactic reaction history to vitamin B₁₂ injections—inject with caution or avoid.
- Relative precautions:
- Leber’s optic atrophy: Potential to accelerate degeneration; use only with ophthalmology guidance :contentReference[oaicite:17]{index=17}.
- Hypokalemia or electrolyte disorders: Monitor during hematologic recovery :contentReference[oaicite:18]{index=18}.
- Renal or hepatic impairment: Adjust dosing frequency and monitor response.
- Pregnancy and lactation: Generally considered safe; follow clinical guidance :contentReference[oaicite:19]{index=19}.
- Pediatric use: Acceptable with adjusted dosing; observe for injection tolerance :contentReference[oaicite:20]{index=20}.
Mecobalamin should only be administered when clinically indicated, with allergy history and condition specifics guiding usage.
Storage of ALGOBAZ 10mg
Proper storage ensures product stability, sterility, and potency.
- Temperature: Maintain between 15 °C and 25 °C (59–77 °F); avoid extremes and freezing :contentReference[oaicite:21]{index=21}.
- Light protection: Store in original box or amber container to prevent photodegradation.
- Moisture control: Keep in a dry area. Lyophilized powder is moisture sensitive.
- Sterility: Single-use vials/ampoules; discard any unused portions after reconstitution.
- Expiry: Adhere to manufacturer’s labeled expiration date; dispose of expired units per protocol.
- Handling: Inspect for particulate matter or discoloration; do not use compromised products.
- Disposal: Treat as medical waste—used vials, needles, and packaging should follow safety biohazard protocols.
ALGOBAZ 10mg features an exceptional active ingredient renowned for its potent effects, comprising Vitamin - B12 (Mecobalamine). This powerful formulation provides a superior solution for addressing diverse health concerns. With 10mg/Vial concentration and an easily manageable Injection/Powder for, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ALGOBAZ 10mg .
Welcome to Dwaey, specifically on ALGOBAZ 10mg page.
This medicine contains an important and useful components, as it consists of Vitamin - B12 (Mecobalamine).
ALGOBAZ 10mg is available in the market in concentration 10mg/Vial and in the form of Injection/Powder for.
SANOFI-CLIN MIDY-LABAZ is the producer of ALGOBAZ 10mg and it is imported from FRANCE,
The most popular alternatives of ALGOBAZ 10mg are listed downward .
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Active Substance
Vitamin - B12 (Mecobalamine)
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Size
4 Vials (Lyophilisate) + 4 Solvent Ampoules (2ml)
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Indications
-
Type
-
Company
Frequently Asked Questions
ALGOBAZ 10mg should be stored according to the instructions provided by SANOFI-CLIN MIDY-LABAZ.
In general, it is recommended to store ALGOBAZ 10mg in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ALGOBAZ 10mg may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ALGOBAZ 10mg for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ALGOBAZ 10mg. Some medications, including
ALGOBAZ 10mg, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ALGOBAZ 10mg, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ALGOBAZ 10mg without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ALGOBAZ 10mg if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ALGOBAZ 10mg during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 10mg/Vial,
and the specific recommendations of SANOFI-CLIN MIDY-LABAZ.
The effects of ALGOBAZ 10mg on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 10mg/Vial, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ALGOBAZ 10mg with or without food may vary depending on the medication
and the recommendations of SANOFI-CLIN MIDY-LABAZ. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ALGOBAZ 10mg in children or elderly individuals may depend on various factors, including
the specific medication, type Injection/Powder for, and the recommendations of SANOFI-CLIN MIDY-LABAZ. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ALGOBAZ 10mg in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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