ALCOS-ANAL Rectal Suppositories

What is ALCOS-ANAL

ALCOS‑ANAL Rectal Suppositories are a locally applied pharmaceutical product designed for treatment of anorectal discomfort and mild inflammatory conditions. Manufactured by NORGINE LIMITED (UK), each suppository contains:

• Chlorothymol: A mild antiseptic compound for antimicrobial action.
• Laureth: A surfactant/emulsifier that supports distribution and may have mild local antiseptic effects.
• Sodium oleate: A soothing fatty acid salt acting as an astringent and emollient.

This combination is available in strengths typically listed as 0.7 mg, 20 mg, and 200 mg per suppository, with packaging in tubes or boxes of 10 suppositories :contentReference[oaicite:1]{index=1}.

Intended use: Local symptomatic relief of anorectal conditions such as internal hemorrhoids, anal fissures, proctitis, anal eczema, and postoperative irritation. By delivering active ingredients directly to the rectal mucosa, ALCOS‑ANAL promotes antisepsis, soothing, and mucosal recovery.

How to use ALCOS-ANAL

Rectal suppositories require careful administration to ensure proper effect and comfort. Follow these professional guidelines:

• Preparation: Gently cleanse the anal area; ensure dryness before insertion.
• Opening: Remove any plastic or foil wrapper just prior to use.
• Positioning: Lie on your left side with your upper leg slightly drawn toward your abdomen, or stand with one leg elevated on a chair :contentReference[oaicite:2]{index=2}.
• Insertion: Moisten the tapered end with water for comfort, then gently insert the suppository about 2 cm (3/4 in) into the rectum until it stays in place :contentReference[oaicite:3]{index=3}.
• Post‑insertion: Remain still for a few minutes to allow melting. Avoid defecating for at least one hour so the medication remains effective :contentReference[oaicite:4]{index=4}.
• Administration frequency: Typically up to 3–4 times daily or as prescribed, ideally after bowel movements and at bedtime.
• Hygiene: Wash hands before and after use and clean or dispose of applicators if provided.

These instructions help optimize delivery to the affected area, enhancing symptom relief.

Mode of Action ALCOS-ANAL

The pharmacological effects of ALCOS‑ANAL suppositories arise from the synergistic properties of their ingredients:

• Chlorothymol: A mild antiseptic that helps prevent secondary bacterial or fungal infection within inflamed anorectal tissue :contentReference[oaicite:5]{index=5}.
• Laureth: A non-ionic surfactant that improves mucosal spread and may contribute to topical antiseptic activity by disrupting microbial membranes :contentReference[oaicite:6]{index=6}.
• Sodium oleate: Acts as both a soothing emollient and mild astringent; it helps restore mucosal barrier function and reduce irritation :contentReference[oaicite:7]{index=7}.

Collectively, these actions ease symptoms such as burning, itching, pain, inflammation, and mild bleeding, supporting natural healing processes and improving mucosal comfort.

ALCOS-ANAL Interactions ALCOS-ANAL

Due to its local application and minimal systemic absorption, ALCOS‑ANAL has a low risk of systemic drug interactions. However, some local considerations apply:

• Other anorectal medications: Avoid using simultaneously with corticosteroid or other medicated suppositories without consulting your physician, to prevent overtreatment.
• Topical sensitivity: Laureth and sodium oleate may cause local irritation in susceptible individuals—monitor for reactions.
• No known systemic drug interactions: Ingredients are minimally absorbed, reducing the likelihood of affecting systemic therapies.

Patients should inform healthcare providers about all local medications being applied to avoid duplication or enhanced mucosal exposure.

Dosage of ALCOS-ANAL

General dosing recommendations (not a substitute for professional advice):

• Adults: Use 1 suppository 2–4 times daily—preferably after bowel movements, before sleep, and morning on waking.
• Pediatrics: Limited data; use only under pediatric guidance.
• Treatment duration: Use regularly for 2–4 weeks, depending on response and clinical severity. Discontinue if no improvement after 7–10 days, or if symptoms worsen.
• Pregnancy/Lactation: Horned limited safety data – only use if benefits outweigh risks, and under medical supervision :contentReference[oaicite:8]{index=8}.

Dosage may be tailored according to physician assessment and symptom severity.

Possible side effects of ALCOS-ANAL

ALCOS‑ANAL is generally well tolerated, but potential side effects include:

• Common mild reactions: Temporary local burning or stinging upon insertion; mild rectal discomfort or mucosal moisture.
• Occasional irritation: Redness, increased sensitivity, or mild inflammation around the rectum due to surfactant components.
• Rare allergic contact dermatitis: Sensitized individuals may develop rash or pruritus—usually reversible post-discontinuation.
• Insertion trauma: Inappropriate or forceful insertion can cause minor bleeding or rectal irritation.

If you experience persistent burning, worsening symptoms, bleeding, or new pain, discontinue use and consult a healthcare provider.

ALCOS-ANAL Contraindications ALCOS-ANAL

• Known hypersensitivity: Allergy to chlorothymol, laureth, sodium oleate, or related compounds :contentReference[oaicite:9]{index=9}.
• Severe anorectal disease: Include ulcerative proctitis, severe proctitis, or malignancy—these require medical investigation.
• Active infections: Bacterial, fungal, viral—or those at high risk of systemic spread—should use targeted antimicrobial therapy.
• Compromised immune status: Use cautiously; immunosuppressed patients may have atypical reactions.

Overall, contraindications largely revolve around hypersensitivity and severe local pathology requiring specialist care.

Storage of ALCOS-ANAL

• Temperature: Store at 15–25 °C, away from excessive heat; do not freeze.
• Packaging: Keep in original blister or box to protect from light and moisture.
• Expiry: Observe and do not use after the printed expiry date.
• Hygiene: Avoid touching tip or wrapper to skin. Use hygienically and re-seal blister if applicable.
• Safety: Keep out of reach of children to avoid accidental insertion or ingestion.

Proper storage ensures product integrity and suitability until dosing.