What is AKLIEF 50 µg/g
AKLIEF 50 µg/g Cream is a topical prescription medication containing the active ingredient Trifarotene, a fourth-generation retinoid. It is specifically developed for the treatment of acne vulgaris in patients aged 9 years and older. Unlike older retinoids, trifarotene is highly selective for the retinoic acid receptor gamma (RAR-γ), the most predominant retinoid receptor in the skin, making it particularly effective and targeted for cutaneous use.
- Form: Cream
- Packaging: 30g in a polypropylene (PP) bottle with a pump and overcap for hygienic and accurate dispensing
- Active Ingredient: Trifarotene 50 micrograms per gram of cream
- Indications: Indicated for the treatment of facial and truncal acne (e.g., on the chest, shoulders, and back)
- Patient population: Suitable for use in children (≥9 years), adolescents, and adults
Trifarotene represents an evolution in topical retinoid therapy, offering both efficacy and tolerability for acne patients, especially those with both facial and body involvement.
How to use AKLIEF 50 µg/g
Proper application of AKLIEF Cream is crucial for achieving the desired therapeutic effects and minimizing the risk of skin irritation.
- Preparation:
- Wash the affected area (face, chest, back, or shoulders) with a mild cleanser and lukewarm water.
- Gently pat the skin dry before application.
- Application instructions:
- Use AKLIEF once daily, preferably in the evening before bedtime.
- Dispense a small amount of cream onto the fingertips (usually one pump is sufficient for the face).
- Apply a thin, even layer to the entire affected area. Avoid contact with eyes, lips, and mucous membranes.
- Do not use more than recommended—overuse may increase irritation without improving efficacy.
- Additional Tips:
- Use a moisturizer to reduce dryness and irritation, ideally applied after the cream has fully dried.
- Apply sunscreen during the day as trifarotene may increase sun sensitivity.
- Do not apply to broken or sunburned skin.
Consistency is key: Results may take 4–8 weeks to become noticeable. Do not stop using AKLIEF abruptly without consulting your healthcare provider.
Mode of Action AKLIEF 50 µg/g
AKLIEF works through the pharmacological activity of its active ingredient, Trifarotene, a retinoid compound that targets specific pathways involved in acne formation.
- Receptor specificity:
- Trifarotene is a selective agonist of the retinoic acid receptor gamma (RAR-γ).
- This receptor is the most abundant retinoic acid receptor in the skin, enabling targeted therapeutic action with fewer systemic effects.
- Cellular effects:
- Regulates the differentiation and proliferation of keratinocytes, reducing abnormal keratinization that leads to clogged pores.
- Promotes the expulsion of comedones and inhibits the formation of new ones.
- Anti-inflammatory action:
- Decreases the inflammatory response within the skin, thereby reducing redness, swelling, and papules/pustules.
- Skin renewal:
- Accelerates epidermal turnover, helping improve skin texture and tone.
These combined effects help to control acne at both the comedonal (non-inflammatory) and inflammatory stages, making AKLIEF a comprehensive topical therapy.
AKLIEF 50 µg/g Interactions AKLIEF 50 µg/g
While topical AKLIEF is less likely to interact with systemic medications due to minimal absorption, certain product combinations may affect its efficacy or increase the risk of side effects.
- Topical medications:
- Avoid simultaneous use of other topical retinoids (e.g., tretinoin, adapalene) to prevent cumulative irritation.
- Use caution when combining with benzoyl peroxide—apply at different times (e.g., benzoyl peroxide in the morning, AKLIEF at night).
- Products containing salicylic acid, sulfur, or resorcinol may intensify drying or peeling effects.
- Cosmetic products:
- Avoid harsh soaps, astringents, and exfoliating agents while using AKLIEF.
- Use gentle, non-comedogenic moisturizers and cleansers to support skin barrier function.
- Photosensitizing agents:
- Drugs that increase photosensitivity (e.g., tetracyclines, thiazides, sulfonamides) may potentiate sunburn risk.
- Oral retinoids:
- Concurrent use with oral isotretinoin is not recommended due to the risk of additive irritation or unknown synergistic effects.
Always inform your healthcare provider of all topical and oral products being used to avoid potential interactions.
Dosage of AKLIEF 50 µg/g
The dosage of AKLIEF is standardized as a once-daily topical application. Individual patient response and skin sensitivity may require dosage adjustments.
- Recommended dose:
- Apply once daily, in the evening.
- One pump is usually sufficient for the entire face; additional pumps may be required for chest, shoulders, or back.
- Dosage adjustment:
- If excessive irritation occurs (peeling, redness, burning), reduce the frequency to every other night or every third night until tolerance improves.
- Resume daily use as tolerated.
- Duration of treatment:
- Continue treatment for at least 8–12 weeks to assess full effectiveness.
- Long-term use may be continued under medical supervision.
- Missed dose:
- If a dose is missed, do not double the next dose. Simply continue with the regular schedule the following evening.
Proper dosing and application technique are crucial for optimal results and tolerability.
Possible side effects of AKLIEF 50 µg/g
As with any topical retinoid, AKLIEF may cause local skin reactions, particularly during the early weeks of treatment. These effects are generally mild to moderate and tend to subside with continued use.
- Common side effects (may affect up to 1 in 10 patients):
- Skin dryness
- Peeling or scaling of the skin
- Redness (erythema)
- Burning or stinging sensation
- Less common side effects:
- Itching (pruritus)
- Sun sensitivity (photosensitivity)
- Skin irritation or discomfort
- Rare side effects:
- Contact dermatitis
- Allergic reaction (e.g., swelling, severe redness)
To reduce irritation, start with every-other-day application and use a gentle moisturizer. Contact your healthcare provider if severe or persistent reactions occur.
AKLIEF 50 µg/g Contraindications AKLIEF 50 µg/g
AKLIEF is generally safe for use in most patients with acne vulgaris, but it should not be used under certain conditions.
- Known hypersensitivity:
- Contraindicated in patients with known allergy to Trifarotene or any of the excipients in the cream formulation.
- Pregnancy:
- While systemic absorption is low, AKLIEF is not recommended during pregnancy due to retinoid-related teratogenic risk.
- Patients of childbearing potential should discuss pregnancy planning with their healthcare provider before using AKLIEF.
- Breastfeeding:
- Use with caution. Avoid applying to areas that may come into direct contact with an infant (e.g., chest).
- Damaged or eczematous skin:
- Avoid application to open wounds, cuts, sunburned, or eczematous skin, as it may worsen irritation.
Always consult a healthcare provider before initiating therapy, particularly in special populations such as pregnant or breastfeeding individuals.
Storage of AKLIEF 50 µg/g
Proper storage ensures the stability and effectiveness of AKLIEF over its shelf life.
- Temperature:
- Store below 25°C (77°F). Do not freeze.
- Packaging:
- Comes in a PP (polypropylene) bottle with a pump dispenser and overcap to maintain hygiene and prevent contamination.
- Light and moisture protection:
- Keep the container tightly closed when not in use. Store in a dry place, away from direct sunlight and humidity.
- Keep out of reach of children:
- Store in a secure location to prevent accidental ingestion or misuse.
- Disposal:
- Do not flush unused medication down the drain or toilet. Follow local regulations for proper disposal.
Always check the expiration date before use and consult your pharmacist or healthcare provider if the product appears discolored or altered.
AKLIEF 50 µg/g features an exceptional active ingredient renowned for its potent effects, comprising Trifarotene. This powerful formulation provides a superior solution for addressing diverse health concerns. With 0.05 mg/g concentration and an easily manageable Cream, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about AKLIEF 50 µg/g .
Welcome to Dwaey, specifically on AKLIEF 50 µg/g page.
This medicine contains an important and useful components, as it consists of Trifarotene.
AKLIEF 50 µg/g is available in the market in concentration 0.05 mg/g and in the form of Cream.
GALDERMA INTERNATIONAL is the producer of AKLIEF 50 µg/g and it is imported from FRANCE,
The most popular alternatives of AKLIEF 50 µg/g are listed downward .
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Active Substance
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Size
1 Polypropylene (PP) Bottle (30 g) with a PP Pump/Overcap
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Indications
- No indications available.
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Type
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Company
Frequently Asked Questions
AKLIEF 50 µg/g should be stored according to the instructions provided by GALDERMA INTERNATIONAL.
In general, it is recommended to store AKLIEF 50 µg/g in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with AKLIEF 50 µg/g may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking AKLIEF 50 µg/g for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking AKLIEF 50 µg/g. Some medications, including
AKLIEF 50 µg/g, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of AKLIEF 50 µg/g, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking AKLIEF 50 µg/g without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking AKLIEF 50 µg/g if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of AKLIEF 50 µg/g during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 0.05 mg/g,
and the specific recommendations of GALDERMA INTERNATIONAL.
The effects of AKLIEF 50 µg/g on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 0.05 mg/g, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking AKLIEF 50 µg/g with or without food may vary depending on the medication
and the recommendations of GALDERMA INTERNATIONAL. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of AKLIEF 50 µg/g in children or elderly individuals may depend on various factors, including
the specific medication, type Cream, and the recommendations of GALDERMA INTERNATIONAL. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of AKLIEF 50 µg/g in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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