ADVIL 12 HOUR BACK & JOINT Tablets/Extended Release

What is ADVIL 12 HOUR BACK & JOINT

ADVIL 12 HOUR BACK & JOINT is a nonsteroidal anti-inflammatory drug (NSAID) that delivers extended pain relief for up to 12 hours. It is specially formulated for people suffering from recurring or chronic joint and back pain, offering both fast-acting and long-lasting relief in a single tablet.

• Generic Name: Ibuprofen USP
• Total Strength per Tablet: 600 mg
  • Immediate-Release (IR) layer: 200 mg
  • Extended-Release (ER) layer: 400 mg
• Dosage Form: Extended-Release Tablets
• Packaging: 30 tablets in a high-density polyethylene (HDPE) bottle
• Indications:
  • Relief of minor aches and pains due to backache and joint pain
  • Relieves inflammation associated with osteoarthritis, rheumatoid arthritis, or musculoskeletal strain

This dual-layer formulation provides fast absorption from the IR portion and sustained pain control from the ER portion, designed to minimize the need for repeated dosing throughout the day.

How to use ADVIL 12 HOUR BACK & JOINT

Using ADVIL 12 HOUR BACK & JOINT properly ensures both safety and maximum effectiveness. It is designed for oral administration and should be taken exactly as directed on the label or by your healthcare provider.

• Recommended Use:
  • Adults and children over 12 years: Take 1 tablet every 12 hours
  • Do not take more than 2 tablets in 24 hours
• Administration Guidelines:
  • Take with a full glass of water
  • Swallow the tablet whole—do not split, crush, or chew
  • Can be taken with food or milk to minimize gastrointestinal discomfort
• Duration of Use:
  • Use the lowest effective dose for the shortest possible duration
  • If pain persists for more than 10 days, consult a healthcare professional

Improper use may increase the risk of gastrointestinal bleeding, cardiovascular complications, or kidney problems. Always read and follow the label instructions.

Mode of Action ADVIL 12 HOUR BACK & JOINT

ADVIL 12 HOUR BACK & JOINT works through a dual-release mechanism using the active ingredient ibuprofen, a non-selective NSAID. It targets inflammation and pain by inhibiting enzymes involved in the body's inflammatory response.

• Immediate-Release Layer (200 mg):
  • Rapidly absorbed after ingestion
  • Provides quick onset of pain relief, usually within 30 minutes
• Extended-Release Layer (400 mg):
  • Slowly releases ibuprofen over 12 hours
  • Maintains steady therapeutic levels in the bloodstream
• Pharmacologic Action:
  • Inhibits cyclooxygenase enzymes (COX-1 and COX-2)
  • Reduces synthesis of prostaglandins, key mediators of pain, fever, and inflammation

This mode of action provides both immediate and sustained relief from musculoskeletal pain without the need for multiple doses per day, enhancing patient compliance and convenience.

ADVIL 12 HOUR BACK & JOINT Interactions ADVIL 12 HOUR BACK & JOINT

Like other NSAIDs, ADVIL 12 HOUR BACK & JOINT may interact with several medications, potentially altering efficacy or increasing the risk of adverse effects.

• Drug-Drug Interactions:
  • Anticoagulants (e.g., warfarin): Increased risk of bleeding
  • Antihypertensives (ACE inhibitors, ARBs, beta-blockers): Reduced effectiveness due to renal effects
  • Diuretics: Increased risk of nephrotoxicity and electrolyte imbalance
  • Other NSAIDs or aspirin: Additive gastrointestinal and renal toxicity
  • SSRIs/SNRIs: Increased risk of gastrointestinal bleeding
• Drug-Food Interaction:
  • Food may delay absorption slightly, but helps minimize stomach upset
• Alcohol:
  • Increases risk of GI bleeding and liver toxicity with chronic use

Always inform your doctor or pharmacist of all medications, supplements, and over-the-counter products you are taking before starting ADVIL 12 HOUR BACK & JOINT.

Dosage of ADVIL 12 HOUR BACK & JOINT

Proper dosing of ADVIL 12 HOUR BACK & JOINT ensures effective pain relief while minimizing the risk of side effects.

• Adult Dosage:
  • Take 1 tablet (600 mg total) every 12 hours as needed
  • Do not exceed 2 tablets (1200 mg) in 24 hours
• Pediatric Use:
  • Not recommended for children under 12 years of age
• Missed Dose:
  • Take as soon as remembered if not too close to the next dose
  • Do not double the dose to make up for a missed one

Use the lowest effective dose for the shortest duration necessary to control symptoms. Chronic or excessive use may increase the risk of gastrointestinal, cardiovascular, or renal complications.

Possible side effects of ADVIL 12 HOUR BACK & JOINT

While generally safe when used correctly, ADVIL 12 HOUR BACK & JOINT can cause side effects, especially with prolonged or high-dose use.

• Common Side Effects:
  • Upset stomach or indigestion
  • Nausea
  • Dizziness or headache
  • Heartburn
• Serious Side Effects:
  • Gastrointestinal bleeding or ulcers (black or tarry stools, vomiting blood)
  • Kidney dysfunction (reduced urination, swelling in legs/feet)
  • Elevated blood pressure or heart failure symptoms
  • Severe allergic reactions (rash, difficulty breathing, swelling of lips or face)
• Long-Term Risks:
  • Increased risk of heart attack or stroke with chronic use
  • Liver toxicity in high doses

If any serious symptoms occur, discontinue use immediately and seek medical attention. Patients with existing heart, liver, or kidney conditions should use ibuprofen with caution.

ADVIL 12 HOUR BACK & JOINT Contraindications ADVIL 12 HOUR BACK & JOINT

ADVIL 12 HOUR BACK & JOINT should not be used in certain populations due to the risk of serious complications.

• Absolute Contraindications:
  • Known hypersensitivity to ibuprofen or other NSAIDs
  • History of asthma, urticaria, or allergic reaction after NSAID use
  • Active peptic ulcer disease or gastrointestinal bleeding
  • Severe heart failure or recent myocardial infarction
• Relative Contraindications (Use with Caution):
  • Chronic kidney disease
  • Liver dysfunction
  • Uncontrolled hypertension
  • Elderly patients (increased risk of side effects)

Consult your healthcare provider before use if you have chronic health conditions, especially cardiovascular, renal, or gastrointestinal disorders.

Storage of ADVIL 12 HOUR BACK & JOINT

To ensure the integrity and potency of ADVIL 12 HOUR BACK & JOINT, proper storage conditions must be followed.

• Temperature:
  • Store at room temperature between 20°C to 25°C (68°F to 77°F)
  • Short-term excursions between 15°C and 30°C are acceptable
• Packaging:
  • Keep in the original HDPE bottle to protect from moisture and light
  • Close the bottle tightly after each use
• Other Considerations:
  • Keep out of reach of children
  • Do not use past the expiration date printed on the packaging
  • Do not store in damp areas like bathrooms

Improper storage may compromise the effectiveness of the medicine. If tablets become discolored, broken, or deteriorated, dispose of them according to local regulations.