What is ADVACEF 500mg
ADVACEF 500mg is a sterile powder formulation intended for injection, containing the active ingredient Ceftriaxone (as sodium). Ceftriaxone is a broad-spectrum, third-generation cephalosporin antibiotic widely used to treat a variety of bacterial infections. The powder form is reconstituted with a suitable diluent before administration via intramuscular or intravenous injection.
This medication is effective against many gram-positive and gram-negative bacteria, including strains responsible for respiratory tract infections, urinary tract infections, skin and soft tissue infections, septicemia, meningitis, gonorrhea, and intra-abdominal infections. ADVACEF 500mg is often used in hospital settings for serious or complicated infections where oral antibiotics may not be suitable.
- Active Ingredient: Ceftriaxone (as sodium)
- Form: Powder for injection (dry vial)
- Administration Routes: Intramuscular (IM) or intravenous (IV)
- Therapeutic Class: Third-generation cephalosporin antibiotic
- Indications: Bacterial infections including pneumonia, meningitis, urinary tract infections, gonorrhea, and septicemia
How to use ADVACEF 500mg
ADVACEF 500mg must be administered under medical supervision, typically in a hospital or clinical environment. It comes as a dry powder that needs reconstitution before injection. Here are the key usage guidelines:
- Reconstitution: Use sterile water for injection, 1% lidocaine (for IM only), or normal saline as the diluent depending on the administration route.
- Administration:
- Intramuscular: Inject deep into a large muscle after reconstitution with lidocaine to reduce pain.
- Intravenous: Inject slowly over 2-4 minutes or as a continuous infusion after dilution in an appropriate intravenous fluid.
- Dosage frequency: Usually given once or twice daily depending on the infection severity and patient condition.
- Duration: Treatment length varies from 1 to 14 days, guided by the clinical response and infection type.
- Precautions: Ensure aseptic technique during preparation and administration to prevent contamination or infection.
- Monitoring: Monitor for allergic reactions, signs of superinfection, and renal or hepatic function during prolonged use.
Mode of Action ADVACEF 500mg
Ceftriaxone, the active ingredient in ADVACEF 500mg, acts by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. The detailed mechanism is:
- Binding to Penicillin-Binding Proteins (PBPs): Ceftriaxone binds irreversibly to specific PBPs located inside the bacterial cell wall.
- Inhibition of Peptidoglycan Cross-linking: PBPs catalyze the final stages of peptidoglycan cross-linking, an essential step for cell wall strength and rigidity. Ceftriaxone blocks this process.
- Cell Wall Weakening: The inhibition leads to a defective cell wall that cannot withstand osmotic pressure, causing cell lysis and death.
- Bactericidal Effect: Unlike some antibiotics that are bacteriostatic, ceftriaxone kills bacteria, making it effective in severe infections.
- Broad Spectrum: It works against many gram-positive and gram-negative bacteria, including resistant strains due to its stability against many beta-lactamases.
ADVACEF 500mg Interactions ADVACEF 500mg
Ceftriaxone may interact with various medications, potentially altering its effectiveness or increasing side effects. Important drug interactions include:
- Calcium-containing solutions: Ceftriaxone can form precipitates with calcium in IV lines or fluids, especially in neonates, causing serious adverse events. Avoid concurrent use or flush IV lines thoroughly.
- Anticoagulants (Warfarin): Ceftriaxone may enhance anticoagulant effects, increasing bleeding risk. Monitor INR and adjust dose as necessary.
- Probenecid: This drug decreases renal tubular secretion of ceftriaxone, increasing its plasma concentration and prolonging effects.
- Other antibiotics: Combining with bacteriostatic antibiotics (e.g., tetracyclines) may antagonize the bactericidal effect of ceftriaxone.
- Vaccines: Ceftriaxone may reduce the efficacy of live bacterial vaccines like typhoid vaccine.
Always inform healthcare providers of all concurrent medications to avoid harmful interactions.
Dosage of ADVACEF 500mg
The dosage of ADVACEF 500mg varies according to the type and severity of infection, patient age, weight, and renal function. General dosage guidelines are:
- Adults:
- Standard dose: 1 to 2 grams once daily or divided into two doses (every 12 hours).
- Severe infections: Up to 4 grams per day in divided doses.
- Gonorrhea: Single dose of 250 mg to 500 mg IM.
- Children:
- 50 to 75 mg/kg/day in one or two divided doses, not to exceed 2 grams per day.
- Renal impairment: Dose adjustment may not be necessary except in severe renal and hepatic impairment, but monitoring is essential.
- Duration: Depends on infection but usually 4 to 14 days; longer courses for meningitis or complicated infections.
Possible side effects of ADVACEF 500mg
ADVACEF 500mg, like all antibiotics, can cause side effects ranging from mild to severe. Common and serious side effects include:
- Common:
- Pain or swelling at injection site
- Diarrhea, nausea, vomiting
- Rash or itching
- Headache or dizziness
- Serious (require immediate medical attention):
- Severe allergic reactions (anaphylaxis): swelling of face, lips, throat, difficulty breathing
- Clostridium difficile-associated diarrhea causing severe colitis
- Hemolytic anemia or blood disorders
- Kidney or liver dysfunction (jaundice, dark urine)
- Seizures (rare, mostly in renal impairment)
- Other: Possible superinfection with resistant bacteria or fungi during prolonged therapy.
Patients should report any unusual or severe symptoms promptly.
ADVACEF 500mg Contraindications ADVACEF 500mg
ADVACEF 500mg should not be used in patients with the following conditions or history:
- Hypersensitivity: Known allergy to ceftriaxone, other cephalosporins, penicillins, or beta-lactam antibiotics.
- Neonates: Especially premature infants or newborns requiring calcium-containing IV fluids due to risk of fatal precipitates.
- History of severe allergic reaction: Patients with prior anaphylaxis or severe hypersensitivity reactions to beta-lactams should avoid ceftriaxone.
- Liver or kidney failure: Use with caution; avoid if severe dysfunction is present unless benefits outweigh risks.
- Concurrent calcium therapy in neonates: Contraindicated due to risk of precipitation and fatal outcomes.
Storage of ADVACEF 500mg
Proper storage of ADVACEF 500mg is critical to maintain its efficacy and safety:
- Temperature: Store the vial at controlled room temperature, between 20°C and 25°C (68°F to 77°F). Protect from freezing.
- Light protection: Keep the vial in its original packaging to protect from light exposure.
- After reconstitution: Use immediately after preparation. If not used immediately, the reconstituted solution should be stored at 2°C to 8°C (refrigerated) and used within 24 hours.
- Handling: Use aseptic technique during reconstitution and discard any unused solution after recommended storage times.
- Keep out of reach of children.
ADVACEF 500mg features an exceptional active ingredient renowned for its potent effects, comprising Ceftriaxone (as sodium). This powerful formulation provides a superior solution for addressing diverse health concerns. With 500mg/Vial concentration and an easily manageable Injection/Powder for, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ADVACEF 500mg .
Welcome to Dwaey, specifically on ADVACEF 500mg page.
This medicine contains an important and useful components, as it consists of Ceftriaxone (as sodium).
ADVACEF 500mg is available in the market in concentration 500mg/Vial and in the form of Injection/Powder for.
NEOPHARMA is the producer of ADVACEF 500mg and it is imported from UAE,
The most popular alternatives of ADVACEF 500mg are listed downward .
-
Active Substance
-
Size
1 Glass Vial (Dry Powder)
-
Indications
-
Type
-
Company
Frequently Asked Questions
ADVACEF 500mg should be stored according to the instructions provided by NEOPHARMA.
In general, it is recommended to store ADVACEF 500mg in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ADVACEF 500mg may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ADVACEF 500mg for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ADVACEF 500mg. Some medications, including
ADVACEF 500mg, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ADVACEF 500mg, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ADVACEF 500mg without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ADVACEF 500mg if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ADVACEF 500mg during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 500mg/Vial,
and the specific recommendations of NEOPHARMA.
The effects of ADVACEF 500mg on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 500mg/Vial, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ADVACEF 500mg with or without food may vary depending on the medication
and the recommendations of NEOPHARMA. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ADVACEF 500mg in children or elderly individuals may depend on various factors, including
the specific medication, type Injection/Powder for, and the recommendations of NEOPHARMA. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ADVACEF 500mg in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
Related Products
0 Comments