ADONIS 5 mg Tablets/Film-coated

What is ADONIS 5 mg

ADONIS 5 mg is a film-coated tablet that contains Tadalafil as its active ingredient. Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor, widely prescribed to manage:

• Erectile dysfunction (ED): Helps men achieve and maintain an erection during sexual activity.
• Benign prostatic hyperplasia (BPH): Improves urinary symptoms such as difficulty in starting the flow of urine, weak stream, and the need to urinate frequently or urgently.
• Pulmonary arterial hypertension (PAH): In select cases, Tadalafil is also used to improve exercise ability in patients with this condition (at different dosing levels).

Each blister pack contains 15 tablets, making it convenient for prolonged daily administration, especially for chronic conditions like BPH or daily ED management. ADONIS 5 mg is typically used in a once-daily low-dose regimen.

How to use ADONIS 5 mg

Using ADONIS 5 mg correctly maximizes its benefits while minimizing side effects. Here are the key points to consider:

• Dosage form: Film-coated tablet, taken orally with water.
• Timing: Can be taken with or without food, preferably at the same time each day.
• Recommended use: For ED and/or BPH, 5 mg once daily is typically prescribed. This daily dosing helps maintain consistent blood levels for continuous effectiveness.
• Swallow whole: Do not crush, chew, or break the tablet.
• Alcohol caution: Limit alcohol intake to avoid enhanced hypotensive effects (e.g., dizziness or fainting).
• Missed dose: Take as soon as remembered unless it’s close to the next dose. Do not double the dose to make up for a missed one.
• Do not self-adjust dose: Always follow the healthcare provider’s recommendations. Changing the dose without medical advice can increase the risk of adverse effects.

Adherence to a consistent daily routine helps achieve optimal results, particularly in the management of BPH or ongoing erectile function support.

Mode of Action ADONIS 5 mg

Tadalafil, the active substance in ADONIS 5 mg, works by enhancing blood flow and relaxing smooth muscles. Here's how it works in detail:

• Inhibits PDE5 enzyme: Tadalafil selectively inhibits the phosphodiesterase type 5 (PDE5) enzyme found primarily in the corpus cavernosum of the penis and in smooth muscles of the prostate and bladder.
• Increases cGMP levels: By inhibiting PDE5, Tadalafil increases levels of cyclic guanosine monophosphate (cGMP). Elevated cGMP promotes relaxation of smooth muscle tissue and vasodilation.
• Enhances erectile function: During sexual stimulation, increased cGMP leads to dilation of the penile arteries and filling of erectile tissue with blood, resulting in an erection.
• Improves urinary symptoms: In BPH, the relaxation of smooth muscles in the bladder and prostate reduces urinary outflow resistance and symptoms like urgency or weak stream.

Note: Sexual stimulation is required for the medicine to exert its effect on erectile function. It does not cause an erection in the absence of sexual arousal.

ADONIS 5 mg Interactions ADONIS 5 mg

ADONIS 5 mg (Tadalafil) can interact with several medications and substances. These interactions may reduce its effectiveness or increase the risk of side effects:

• Nitrates (e.g., nitroglycerin): Dangerous drop in blood pressure can occur. Tadalafil should not be used with any nitrate medication.
• Alpha-blockers (e.g., doxazosin): Concurrent use can cause symptomatic hypotension. Use with caution and under medical supervision.
• Antihypertensives: May enhance the blood pressure-lowering effects. Monitor for dizziness or lightheadedness.
• CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): Can increase tadalafil blood levels, raising the risk of side effects. Dose adjustment may be required.
• CYP3A4 inducers (e.g., rifampicin): May decrease tadalafil efficacy by speeding up its breakdown.
• Alcohol: Large amounts may amplify the risk of side effects like dizziness or fainting.

Always inform your doctor about all prescription, OTC, and herbal medications you're taking before starting ADONIS 5 mg.

Dosage of ADONIS 5 mg

The dosage of ADONIS 5 mg depends on the condition being treated and the patient’s individual response to therapy:

• Erectile dysfunction (ED) - Daily use: 5 mg taken at the same time each day, regardless of sexual activity. This regimen supports spontaneous sexual activity without the need to time the dose.
• Benign prostatic hyperplasia (BPH): 5 mg once daily. Provides continuous symptom relief for urinary tract symptoms.
• Combination of ED and BPH: 5 mg once daily is also recommended.

Key considerations:

• Do not exceed the recommended daily dose of 5 mg.
• Patients with hepatic or renal impairment may require dose adjustments or should avoid use depending on severity.
• Older adults generally do not require dose adjustment unless there is comorbid organ impairment.

Always follow your physician’s instructions precisely to ensure both safety and therapeutic success.

Possible side effects of ADONIS 5 mg

Like all medicines, ADONIS 5 mg can cause side effects, though not everyone will experience them. Side effects are usually mild to moderate and transient.

• Very common (≥10%): Headache, indigestion (dyspepsia)
• Common (1–10%): Back pain, muscle aches, flushing, nasal congestion, limb pain
• Uncommon (0.1–1%): Dizziness, blurred vision, eye pain, increased heart rate, palpitations
• Rare but serious:
  • Priapism (prolonged or painful erection lasting over 4 hours)
  • Sudden hearing loss or ringing in the ears (tinnitus)
  • Sudden vision loss (non-arteritic anterior ischemic optic neuropathy – NAION)
  • Allergic reactions (rash, facial swelling, difficulty breathing)

If you experience chest pain, severe dizziness, or signs of an allergic reaction, seek immediate medical attention.

ADONIS 5 mg Contraindications ADONIS 5 mg

ADONIS 5 mg should not be used in certain medical conditions or with specific medications. The main contraindications include:

• Use of nitrates: Concomitant use with nitrates or nitric oxide donors (e.g., amyl nitrite) is strictly contraindicated due to the risk of severe hypotension.
• Severe cardiovascular conditions: Not suitable for patients with unstable angina, recent myocardial infarction or stroke (within 90 days), or severe heart failure.
• Severe liver or kidney impairment: Use may be restricted or contraindicated depending on clinical assessment.
• Hypersensitivity: Known allergy to Tadalafil or any component of the formulation.
• Retinal disorders: Including hereditary degenerative retinal disorders such as retinitis pigmentosa.

Before starting ADONIS 5 mg, your doctor will assess your overall health status, particularly cardiovascular fitness for sexual activity.

Storage of ADONIS 5 mg

Proper storage of ADONIS 5 mg helps maintain its effectiveness and safety. Follow these guidelines:

• Temperature: Store at below 30°C (86°F).
• Keep dry: Protect from moisture and humidity. Do not store in the bathroom or near sinks.
• Original packaging: Keep in the original blister pack until use to protect from light and contamination.
• Keep out of reach of children: Always store in a secure location inaccessible to children and pets.
• Do not use after expiry date: Check the packaging for the expiry date and discard any expired tablets appropriately.

Unused or expired medication should be disposed of according to local pharmaceutical disposal regulations—do not flush or throw in household waste.