ADONIS 20 mg Tablets/Film-coated

What is ADONIS 20 mg

ADONIS 20 mg is a film-coated tablet containing Tadalafil, a selective phosphodiesterase type 5 (PDE5) inhibitor. It is primarily prescribed for the treatment of erectile dysfunction (ED) in adult men. Tadalafil works by enhancing blood flow to the penis, facilitating the achievement and maintenance of an erection in response to sexual stimulation. Key Features: Active Ingredient: Tadalafil Dosage Form: Film-coated tablet Strength: 20 mg Packaging: 15 tablets per blister pack Therapeutic Class: PDE5 inhibitor Prescription Status: Prescription-only medication fda.report Tadalafil is also indicated for the treatment of benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension (PAH) under different brand names and dosages. However, ADONIS 20 mg is specifically formulated for managing erectile dysfunction.

How to use ADONIS 20 mg

Administration Guidelines: Dosage: Take one 20 mg tablet orally, at least 30 minutes before anticipated sexual activity. Frequency: Do not take more than one tablet in a 24-hour period. With or Without Food: ADONIS 20 mg can be taken with or without food. However, high-fat meals may delay the onset of action. Swallowing: Swallow the tablet whole with a glass of water; do not crush or chew. Sexual Stimulation: Sexual arousal is necessary for the medication to be effective. Special Considerations: Alcohol Consumption: Excessive alcohol intake may increase the risk of side effects such as dizziness and hypotension. Grapefruit Juice: Avoid grapefruit juice as it can interfere with the metabolism of Tadalafil, leading to increased plasma concentrations. Missed Dose: If you miss a dose and still intend to engage in sexual activity, take the missed dose as soon as you remember. Do not double the dose to make up for a missed one. Always follow your healthcare provider's instructions regarding dosage and administration.

Mode of Action ADONIS 20 mg

Tadalafil, the active ingredient in ADONIS 20 mg, functions by inhibiting the enzyme phosphodiesterase type 5 (PDE5). This inhibition leads to increased levels of cyclic guanosine monophosphate (cGMP), resulting in smooth muscle relaxation and vasodilation in the corpus cavernosum of the penis. The enhanced blood flow facilitates the achievement and maintenance of an erection during sexual stimulation. Pharmacokinetics: Onset of Action: Approximately 30 minutes after oral administration. Duration of Effect: Up to 36 hours, allowing for greater spontaneity. Half-Life: Approximately 17.5 hours. Metabolism: Primarily metabolized by the liver enzyme CYP3A4. Excretion: Eliminated mainly in feces (61%) and urine (36%). go.drugbank.com +1 en.wikipedia.org +1 This prolonged duration distinguishes Tadalafil from other PDE5 inhibitors, offering a longer window of opportunity for sexual activity.

ADONIS 20 mg Interactions ADONIS 20 mg

Tadalafil can interact with various medications and substances, potentially leading to adverse effects or reduced efficacy. Contraindicated Combinations: Nitrates: Concurrent use with nitrates (e.g., nitroglycerin) can cause severe hypotension and is contraindicated. Guanylate Cyclase Stimulators: Co-administration with drugs like riociguat is contraindicated due to the risk of symptomatic hypotension. medicines.org.uk +4 medthority.com +4 patient-info.co.uk +4 Medications Requiring Caution: Alpha-Blockers: Co-administration may lead to symptomatic hypotension. CYP3A4 Inhibitors: Drugs such as ketoconazole, ritonavir, and erythromycin can increase Tadalafil levels, necessitating dose adjustments. CYP3A4 Inducers: Rifampin and similar drugs may decrease Tadalafil efficacy by increasing its metabolism. patient-info.co.uk +4 medicines.org.uk +4 medicines.org.uk +4 Other Considerations: Alcohol: Excessive consumption can enhance the hypotensive effects of Tadalafil. Grapefruit Juice: May increase plasma concentrations of Tadalafil, leading to increased side effects. Always inform your healthcare provider about all medications and supplements you are taking to avoid potential interactions.

Dosage of ADONIS 20 mg

ADONIS 20 mg is intended for use in adult men with erectile dysfunction. Standard Dosage: Erectile Dysfunction: One 20 mg tablet taken before anticipated sexual activity. Do not exceed one tablet in 24 hours. Special Populations: Renal Impairment: Use with caution; dose adjustments may be necessary. Hepatic Impairment: Not recommended in severe hepatic impairment. Elderly Patients: No dosage adjustment required solely based on age. medicines.org.uk Daily Use: For conditions like BPH or if daily use is prescribed, lower doses (e.g., 2.5 mg or 5 mg) are typically used. ADONIS 20 mg is not intended for daily use. Consult your healthcare provider for personalized dosing recommendations.

Possible side effects of ADONIS 20 mg

While many individuals tolerate Tadalafil well, some may experience side effects. Common Side Effects: Headache Back pain Muscle aches Flushing Nasal congestion Indigestion medicines.org.uk +4 medicines.org.uk +4 patient-info.co.uk +4 en.wikipedia.org Uncommon Side Effects: Dizziness Blurred vision Changes in color vision Erections lasting more than 4 hours (priapism) medicines.org.uk +1 medthority.com +1 Rare but Serious Side Effects: Sudden hearing loss Sudden vision loss Chest pain Allergic reactions (e.g., rash, itching, swelling) Seek immediate medical attention if you experience any serious side effects.

ADONIS 20 mg Contraindications ADONIS 20 mg

ADONIS 20 mg should not be used in certain populations due to potential risks. Absolute Contraindications: Concurrent use of nitrates or nitric oxide donors. Known hypersensitivity to Tadalafil or any component of the tablet. Severe cardiovascular disorders where sexual activity is inadvisable. History of non-arteritic anterior ischemic optic neuropathy (NAION). Severe hepatic or renal impairment. medthority.com +3 medicines.org.uk +3 patient-info.co.uk +3 medicines.org.uk +3 medthority.com +3 patient-info.co.uk +3 medthority.com +4 patient-info.co.uk +4 medicines.org.uk +4 medthority.com Relative Contraindications: Anatomical deformation of the penis (e.g., Peyronie's disease). Conditions predisposing to priapism (e.g., sickle cell anemia, multiple myeloma). Uncontrolled hypertension or hypotension. medicines.org.uk +1 medthority.com +1 medthority.com +1 medicines.org.uk +1 A thorough medical evaluation is essential before initiating therapy with ADONIS 20 mg.

Storage of ADONIS 20 mg

Proper storage ensures the medication's efficacy and safety. Storage Guidelines: Temperature: Store at room temperature between 15°C and 30°C (59°F to 86°F). Humidity: Keep in a dry place; avoid exposure to moisture. Light: Store away from direct sunlight. Packaging: Keep tablets in their original blister pack until use. Child Safety: Store out of reach of children and pets. Disposal: Do not use after the expiration date. Dispose of unused or expired medication according to local regulations. Always check the packaging for specific storage instructions.