What is ADONIS 20 mg
ADONIS 20 mg is a film-coated tablet containing 20 mg of tadalafil, a
phosphodiesterase-type-5 (PDE-5) inhibitor indicated primarily for the
symptomatic treatment of erectile dysfunction (ED) in adult males. Tadalafil
is also approved, at lower daily doses, for benign prostatic hyperplasia (BPH)
and pulmonary arterial hypertension (PAH); however, ADONIS 20 mg is
formulated for the on-demand management of ED, offering a
therapeutic window of up to 36 hours—considerably longer than first-generation
PDE-5 inhibitors.
- Active ingredient: Tadalafil 20 mg per tablet (film-coated).
- Pharmacological class: Selective, reversible PDE-5 inhibitor.
- Key benefit: Facilitates penile erection in response to
sexual stimulation by enhancing nitric-oxide–cGMP signalling in the
corpus cavernosum.
- Onset & duration: Median onset ≈ 30 minutes (range
15–45 min); therapeutic effect may persist for up to 36 hours, earning the
nickname “the weekend pill.”
- Regulatory status: Prescription-only medicine (Rx); not
indicated for use in women or persons < 18 years.
- Distinguishing features: Longer half-life (~17.5 h)
compared with sildenafil or vardenafil, allowing greater
spontaneity.
- Packaging: Blister pack of four tablets, each embossed
for dose verification and coated to mask taste.
- Manufacturer information: See outer carton or
patient-information leaflet (PIL) for MA holder, batch number, and
expiry.
- Therapeutic context: Should be part of a broader ED
work-up that screens for cardiovascular disease, endocrine disorders, or
psychosocial factors.
- Patient counselling tip: ADONIS 20 mg does not
increase libido; sexual arousal is still required to achieve an erection.
How to use ADONIS 20 mg
Correct use maximises efficacy while minimising adverse events. The guidance
below reflects current consensus (European Association of Urology, 2023)
and manufacturer recommendations.
- Timing: Swallow one tablet with water at least
30 minutes before anticipated sexual activity; a light meal has no
clinically relevant effect, but a high-fat meal may delay onset.
- Frequency: Do not exceed one 20 mg tablet
within a 24-hour period; the prolonged half-life means repeat dosing
confers minimal added benefit and raises risk of adverse effects.
- Administration route: Oral; do not crush or split the
film-coated tablet.
- Hydration: Take with a full glass of water to aid
oesophageal transit and reduce dyspepsia.
- Alcohol: Limit to ≤ 5 units; excessive alcohol amplifies
hypotensive effects and impairs erectile function independently.
- Missed opportunity: If sexual activity is postponed,
no “make-up” dose is needed; wait ≥ 24 h before the next tablet.
- Special populations:
- Elderly (≥ 65 y): No routine dose adjustment, but start at
10 mg in frail adults.
- Renal impairment: Moderate (CrCl 30–50 mL/min)—
maximum 10 mg once every 48 h; severe (CrCl < 30 mL/min)—
avoid.
- Hepatic impairment: Mild-to-moderate (Child-Pugh A/B)—
consider 10 mg; severe (Child-Pugh C)—contraindicated.
- Patient follow-up: Reassess efficacy, tolerability, and
cardiovascular status after 4–6 doses; consider alternative doses or daily
5 mg regimen if spontaneity is a priority.
- Partner involvement: Encourage open discussion with the
partner to align expectations and alleviate performance anxiety.
Mode of Action ADONIS 20 mg
Tadalafil exerts its pro-erectile effect by selectively inhibiting
phosphodiesterase-type-5 (PDE-5), the enzyme responsible for degradation of
cyclic guanosine monophosphate (cGMP) in the smooth muscle of the corpus
cavernosum.
- Physiological cascade: Sexual stimulation releases
nitric oxide (NO) from non-adrenergic, non-cholinergic neurons and
endothelium ➜ NO activates guanylate cyclase ➜ ↑ cGMP ➜
smooth-muscle relaxation ➜ vasodilatation ➜ increased arterial inflow and
restricted venous outflow ➜ erection.
- Enzymatic blockade: PDE-5 hydrolyses cGMP to inactive
5′-GMP. By inhibiting PDE-5, tadalafil sustains cGMP levels, amplifying and
prolonging the vasodilatory response.
- Selectivity: High affinity for PDE-5 with a
≥ 10-fold selectivity over PDE-6 (retina) and ≥ 700-fold over PDE-3
(cardiac/vascular), reducing visual and cardiac side effects compared with
less selective agents.
- Pharmacokinetics: Oral bioavailability ≈ 80%; peak
plasma concentration (Tmax) in 2 h; protein binding 94%;
half-life ~17.5 h, accounting for the 36-h therapeutic window.
- Metabolism & elimination: Hepatic CYP3A4-mediated
oxidation to inactive catechol metabolites ➜ renal and faecal excretion.
- Haemodynamic profile: Minimal effect on systemic blood
pressure in normotensive men; potentiation occurs with nitrates and
α-blockers, underscoring interaction risks.
- Extra-cavernosal effects: PDE-5 is expressed in
prostate, bladder, and pulmonary vasculature, explaining efficacy in BPH
symptom relief and PAH at alternative dosing.
ADONIS 20 mg Interactions ADONIS 20 mg
Tadalafil’s safety profile depends heavily on recognising pharmacodynamic and
pharmacokinetic interactions. Co-administration with the following agents or
substances warrants caution or outright avoidance:
- Nitrates (e.g., nitroglycerin, isosorbide dinitrate):
Absolute contraindication. Synergistic NO-cGMP elevation can cause
profound, refractory hypotension.
- Guanylate cyclase stimulators (riociguat): Additive
hypotension—avoid.
- α-Adrenergic blockers (doxazosin, tamsulosin): Start
at the lowest α-blocker dose and separate administrations by ≥ 6 h; monitor
blood pressure.
- Potent CYP3A4 inhibitors
(e.g., ketoconazole, ritonavir, cobicistat, clarithromycin):
↓ tadalafil clearance ➜ ↑ AUC; limit tadalafil to 10 mg every 72 h or
avoid.
- CYP3A4 inducers (e.g., rifampicin, carbamazepine,
phenytoin, St John’s Wort): ↑ tadalafil metabolism ➜ therapeutic failure;
consider dose adjustment or alternative therapy.
- Antihypertensives (ACEIs, ARBs, β-blockers, diuretics):
Modest additional BP reduction; monitor for dizziness or syncope.
- Ethanol: High intake potentiates orthostatic
hypotension and dizziness; counsel moderation.
- Grapefruit juice: Moderate CYP3A4 inhibition may
elevate tadalafil levels; occasional consumption is unlikely to be
clinically significant but advise spacing by ≥ 24 h.
- Other PDE-5 inhibitors (sildenafil, vardenafil) or
recreational “poppers” (amyl nitrite): Concomitant use is unsafe
and offers no added benefit.
Dosage of ADONIS 20 mg
The 20 mg strength is formulated for on-demand use in erectile
dysfunction, not for daily chronic administration. Evidence-based dosing
strategy:
- Standard adult dose: One 20 mg tablet taken orally
prior to anticipated sexual activity; effective from 30 min up to 36 h.
- Initiation: In treatment-naïve patients, consider
starting at 10 mg to assess tolerability; escalate to 20 mg if response
is inadequate.
- Maximum frequency: Once daily; repeated dosing within
24 h confers little benefit due to long half-life.
- Renal adjustment:
- Creatinine clearance 30–50 mL/min: 10 mg as needed, max every 48 h.
- < 30 mL/min or on dialysis: Use not recommended.
- Hepatic adjustment:
- Mild-to-moderate impairment (Child-Pugh A/B): Begin with 10 mg.
- Severe impairment (Child-Pugh C): Contraindicated.
- Elderly (≥ 65 y): Pharmacokinetics largely unchanged;
clinical judgement dictates starting at 10 mg if comorbidities present.
- Duration of trial: Evaluate efficacy after at least
four attempts; psychological factors may require more exposures for
reliable assessment.
- Switching regimens: Patients needing greater
spontaneity can transition to 5 mg once daily, taken at the same time each
day regardless of sexual activity.
- Therapy review: Re-evaluate cardiovascular risk,
medication interactions, and ED aetiology at 3- to 6-month intervals.
Possible side effects of ADONIS 20 mg
Tadalafil is generally well-tolerated; most adverse events are mild-to-moderate
and transient. Vigilance remains essential, especially in polypharmacy and
cardiovascular disease.
- Very common (≥ 10 %):
- Common (1–10 %):
- Dyspepsia, gastro-oesophageal reflux
- Nasal congestion, rhinitis
- Back pain, myalgia (often delayed 12–24 h post-dose)
- Dizziness
- Visual colour tinge or mild blurred vision
- Uncommon (0.1–1 %):
- Palpitations, tachycardia
- Hypotension or hypertension
- Epistaxis
- Ocular hyperaemia
- Rash, pruritus
- Rare (< 0.1 %):
- Priapism (erection > 4 h)—urological emergency
- Non-arteritic anterior ischaemic optic neuropathy (NAION)
- Sudden hearing loss, tinnitus
- Severe cutaneous reactions (Stevens-Johnson syndrome)
- Angina, myocardial infarction in predisposed patients
- Post-marketing signals: Hypersensitivity,
stroke, ventricular arrhythmia—causality often confounded by underlying
cardiovascular risk.
- Management: Advise patients to seek immediate medical
attention for chest pain, vision/hearing changes, or erections
> 4 h.
ADONIS 20 mg Contraindications ADONIS 20 mg
Tadalafil must not be used where the risk of adverse cardiovascular or
drug-induced events outweighs the benefit.
- Concomitant nitrate therapy: Any form of organic
nitrate or nitric-oxide donor.
- Severe cardiovascular disorders:
- Recent myocardial infarction or stroke (< 90 days)
- Unstable angina, uncontrolled arrhythmias
- Severe hypotension (BP < 90/50 mmHg) or uncontrolled hypertension
(BP > 170/100 mmHg)
- NYHA class III–IV heart failure not stabilised on therapy
- Severe hepatic impairment (Child-Pugh C)
- Severe renal impairment (CrCl < 30 mL/min) or dialysis
dependence
- Hereditary degenerative retinal disorders
(e.g., retinitis pigmentosa)
- Known hypersensitivity to tadalafil or excipients
- Concomitant guanylate cyclase stimulators
(e.g., riociguat)
- Pediatrics: Safety and efficacy not established in
individuals < 18 years
Storage of ADONIS 20 mg
Proper storage preserves drug potency and patient safety.
- Temperature: Store below 30 °C (86 °F); avoid
refrigeration or freezing.
- Humidity: Keep in the original aluminium-PVC blister
until use to protect from moisture; do not decant into pill organisers
unless moisture-proof.
- Light protection: Film-coated tablets are stable under
normal lighting, but prolonged exposure to direct sunlight should be
avoided.
- Child safety: Store out of sight and reach of children;
consider a locked cabinet for households with minors.
- Transportation: During travel, use an insulated pouch
if ambient temperatures exceed 30 °C (e.g., summer car glove box).
- Expiry: Check the embossed date on the carton and
each blister; discard unused tablets after expiry or if integrity is
compromised (e.g., tablets chipped or discoloured).
- Disposal: Return expired or unused medication to a
pharmacy take-back program; avoid flushing or discarding in household
trash to reduce environmental impact.
- Patient reminder: Retain the package insert for
reference on interactions, side effects, and emergency guidance.
ADONIS 20 mg features an exceptional active ingredient renowned for its potent effects, comprising Tadalafil
. This powerful formulation provides a superior solution for addressing diverse health concerns. With 20mg/Tablet
concentration and an easily manageable Tablets/Film-coated, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ADONIS 20 mg .
Welcome to Dwaey, specifically on ADONIS 20 mg page.
This medicine contains an important and useful components, as it consists of Tadalafil
.
ADONIS 20 mg is available in the market in concentration 20mg/Tablet
and in the form of Tablets/Film-coated.
PHARMAX PHARMACEUTICALS FZ LLC is the producer of ADONIS 20 mg and it is imported from UAE,
The most popular alternatives of ADONIS 20 mg are listed downward .
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Active Substance
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Size
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Indications
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Type
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Company
PHARMAX PHARMACEUTICALS FZ LLC
Frequently Asked Questions
ADONIS 20 mg should be stored according to the instructions provided by PHARMAX PHARMACEUTICALS FZ LLC.
In general, it is recommended to store ADONIS 20 mg in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ADONIS 20 mg may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ADONIS 20 mg for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ADONIS 20 mg. Some medications, including
ADONIS 20 mg, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ADONIS 20 mg, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ADONIS 20 mg without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ADONIS 20 mg if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ADONIS 20 mg during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 20mg/Tablet
,
and the specific recommendations of PHARMAX PHARMACEUTICALS FZ LLC.
The effects of ADONIS 20 mg on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 20mg/Tablet
, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ADONIS 20 mg with or without food may vary depending on the medication
and the recommendations of PHARMAX PHARMACEUTICALS FZ LLC. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ADONIS 20 mg in children or elderly individuals may depend on various factors, including
the specific medication, type Tablets/Film-coated, and the recommendations of PHARMAX PHARMACEUTICALS FZ LLC. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ADONIS 20 mg in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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