ADOL 500mg Tablets (Caplets)

What is ADOL 500mg

ADOL 500mg Tablets (Caplets) contain Paracetamol as the active ingredient. Paracetamol, also known as acetaminophen in some countries, is a widely used analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used to treat mild to moderate pain and fever across all age groups.

• Brand: ADOL
• Strength: 500mg per tablet
• Form: Caplets (Tablet form with a smooth coating for easier swallowing)
• Pack size: 24 tablets (2 blisters of 12 tablets each)
• Generic Name: Paracetamol

ADOL is a trusted over-the-counter medicine that offers symptomatic relief from a wide range of conditions such as headaches, toothaches, menstrual cramps, muscle aches, arthritis-related pain, and fever caused by infections like the common cold or flu.

Due to its well-established safety profile when used appropriately, Paracetamol is often recommended as a first-line treatment for pain and fever in adults and children. However, its misuse—especially overdosing—can lead to serious liver damage, making correct use essential.

How to use ADOL 500mg

To ensure safe and effective use of ADOL 500mg Tablets, always follow the instructions provided by your physician or pharmacist. Self-medication without proper guidance can increase the risk of overdose or mask underlying health issues.

• For Adults and children over 12 years: Take 1 to 2 tablets (500–1000 mg) every 4 to 6 hours as needed.
• Maximum dose: Do not exceed 8 tablets (4000 mg) in 24 hours.
• For children under 12 years: Use a pediatric formulation unless otherwise directed by a healthcare provider.

Administration Guidelines:

• Swallow the tablet whole with a full glass of water. Do not chew or crush.
• Can be taken with or without food, although taking it with food may reduce stomach irritation.
• Maintain regular intervals between doses—do not double a dose to make up for a missed one.

Warnings:

• Avoid alcohol while taking ADOL to reduce the risk of liver damage.
• Check other medications you may be taking—many cough and cold products also contain paracetamol.

Always consult your doctor if your symptoms persist for more than 3 days, or if you develop new symptoms while using this medication.

Mode of Action ADOL 500mg

Paracetamol, the active ingredient in ADOL 500mg, exhibits both analgesic and antipyretic properties but lacks anti-inflammatory action. Its precise mechanism of action is not fully understood, but several pathways contribute to its therapeutic effects.

• Central action: Paracetamol primarily acts on the central nervous system by inhibiting the synthesis of prostaglandins, which are chemicals responsible for pain and fever.
• COX inhibition: It selectively inhibits cyclooxygenase (COX) enzymes in the brain (COX-3 pathway), unlike NSAIDs which act both peripherally and centrally.
• Thermoregulation: It exerts an antipyretic effect by acting on the hypothalamic heat-regulating center, promoting vasodilation and sweating to dissipate body heat.

Key Characteristics:

• Onset of action: Within 30 to 60 minutes after oral administration.
• Peak effect: 1 to 2 hours post-ingestion.
• Duration: Analgesic and antipyretic effects last approximately 4 to 6 hours.

Paracetamol does not have a significant effect on platelet aggregation or gastric mucosa, which makes it safer for individuals at risk of gastrointestinal bleeding or ulcers compared to NSAIDs.

Its central mechanism of action, combined with low side effect profile, makes ADOL 500mg an ideal choice for mild to moderate pain and fever.

ADOL 500mg Interactions ADOL 500mg

While ADOL 500mg (Paracetamol) is considered safe when used as directed, it can interact with other medications, especially when used long-term or in high doses. Understanding these interactions is important to prevent adverse effects.

Common drug interactions include:

• Warfarin and other anticoagulants: Prolonged use of paracetamol may enhance the anticoagulant effect, increasing the risk of bleeding. Occasional use is generally safe.
• Alcohol: Chronic alcohol consumption can increase the risk of hepatotoxicity when combined with paracetamol.
• Rifampicin, Carbamazepine, Phenytoin: These drugs induce liver enzymes that may increase the metabolism of paracetamol, reducing its effectiveness and increasing the risk of liver damage.
• Cholestyramine: May reduce the absorption of paracetamol if taken within 1 hour of the dose.
• Metoclopramide and Domperidone: These drugs may increase the rate of absorption of paracetamol, potentially increasing onset of action.

Safety Tips:

• Always inform your healthcare provider of all medications you are taking, including OTC drugs and supplements.
• Check labels of combination products to avoid exceeding the recommended daily dose of paracetamol.

Dosage of ADOL 500mg

Proper dosing of ADOL 500mg ensures both safety and efficacy. The dosage may vary depending on age, body weight, and the severity of the condition being treated.

Standard Dosage Guidelines:

• Adults and adolescents (≥12 years): 500 mg to 1000 mg (1 to 2 tablets) every 4–6 hours as needed.
• Maximum dose: Do not exceed 4000 mg (8 tablets) in 24 hours.
• Elderly patients: Same adult dose, but with careful monitoring due to possible reduced liver function.

Special Populations:

• Patients with liver or kidney impairment: Dosage adjustment may be necessary under medical supervision.
• Pregnant and breastfeeding women: Paracetamol is considered safe, but it's still best to consult a healthcare professional before use.

Important Considerations:

• Do not use ADOL for more than 3 consecutive days without medical advice.
• In case of a missed dose, take it as soon as you remember. If it’s close to the next dose, skip it—do not double up.

Possible side effects of ADOL 500mg

Paracetamol is generally well tolerated, but like any medication, ADOL 500mg can cause side effects, especially when taken in high doses or for extended periods.

Common side effects (rare at recommended doses):

• Nausea or upset stomach
• Skin rash or itching
• Fatigue or dizziness (rare)

Serious but rare side effects include:

• Hepatotoxicity (liver damage): Especially in cases of overdose or chronic alcohol use.
• Allergic reactions: Swelling, hives, or difficulty breathing (requires emergency care).
• Blood disorders: Such as thrombocytopenia or neutropenia (very rare).

Signs of Paracetamol Overdose:

• Loss of appetite
• Right upper abdominal pain
• Dark urine or jaundice (yellowing of skin/eyes)
• Nausea, vomiting, confusion

Seek immediate medical attention if you suspect overdose, even if symptoms are not immediately present. Early intervention can prevent serious liver damage.

ADOL 500mg Contraindications ADOL 500mg

ADOL 500mg should not be used in certain conditions or situations to avoid harm.

Contraindicated in:

• Hypersensitivity: Individuals with known allergy to paracetamol or any tablet component.
• Severe liver impairment: Paracetamol is metabolized in the liver, and any existing liver condition may worsen.
• Severe renal impairment: Dose adjustment is required, and use may be contraindicated in end-stage disease.

Use with caution in:

• Patients with chronic alcoholism
• Patients taking other hepatotoxic drugs
• Dehydrated individuals or those with poor nutritional status

If you're unsure whether you should take ADOL 500mg, consult your healthcare provider for a proper risk-benefit assessment.

Storage of ADOL 500mg

Proper storage ensures the medication maintains its quality, potency, and safety until its expiration date.

Storage recommendations for ADOL 500mg:

• Store below 25°C (77°F) in a dry place.
• Keep the tablets in the original blister packaging until use to protect from moisture and light.
• Do not store in the bathroom or near a sink to avoid exposure to humidity.
• Keep out of reach and sight of children.

Disposal:

• Do not flush tablets down the toilet or pour into drains.
• Return unused or expired medication to a pharmacy or follow local disposal guidelines.

Always check the expiry date before use. Do not use ADOL 500mg if the packaging is damaged or tablets appear discolored or degraded.