What is ADOL 500mg
ADOL 500 mg rectal suppositories are a single-ingredient, non-opioid analgesic and antipyretic preparation containing paracetamol (acetaminophen) 500 mg in a hydrogenated fat base. Formulated for rectal administration, they provide an alternative route when oral intake is impractical—such as in vomiting, peri-operative patients, or children who refuse tablets.
- Therapeutic class: Analgesic/antipyretic (ATC code N02BE01).
- Indications:
- Symptomatic relief of mild-to-moderate pain (headache, dental pain, musculoskeletal aches, dysmenorrhoea, post-operative pain).
- Reduction of fever of any aetiology (viral infections, post-immunisation pyrexia, etc.).
- Onset & duration: Analgesia begins ~30–60 min after insertion; antipyresis peaks by 2 h. Effect lasts 4–6 h.
- Why rectal? Bypasses gastric irritation and first-pass variability, offers steady absorption, and is valuable when IV access is unavailable.
- Packaging: Each carton contains two PVC-Alu blisters, five suppositories per strip (10 suppositories total).
- Regulatory status: OTC in many jurisdictions; schedule may vary—check local laws.
How to use ADOL 500mg
Correct insertion maximises efficacy and minimises mucosal trauma. Follow these evidence-based steps:
- Preparation
- Wash hands with soap and warm water; dry thoroughly.
- If the suppository feels soft (ambient > 30 °C), chill in a refrigerator for 5–10 min or run cold water over the foil to harden it.
- Positioning
- Lateral (Sim’s) or dorsal recumbent with knees flexed is ideal. Children can be placed prone across the caregiver’s lap.
- Insertion technique
- Peel the foil from the suppository—never cut with scissors, which may scratch the surface.
- Moisten the tapered end with a drop of water or a water-based lubricant if necessary.
- With gentle pressure, introduce the pointed end past the internal sphincter (~2.5 cm in adults, ~1.5 cm in children) to prevent expulsion.
- Maintain position for 2–3 min; encourage children to lie still for 5 min.
- Hygiene – Rewash hands; discard packaging responsibly.
- Missed dose – Insert as soon as remembered if pain/fever persists, respecting minimum 4-h interval; never double doses.
- Special populations
- Liver disease: Consult a physician before use; cumulative dose often limited to ≤ 2 g/day.
- Renal impairment: Dosing interval may be extended to 6–8 h if eGFR < 30 mL/min.
Mode of Action ADOL 500mg
Although paracetamol has been in therapeutic use since 1893, its pharmacodynamics remain only partially elucidated. Current consensus highlights a centrally mediated, multifactorial mechanism:
- Cyclo-oxygenase (COX) inhibition
- Selectively inhibits a brain-specific COX-2 variant (sometimes termed COX-3), reducing synthesis of prostaglandin E₂—key in fever and pain transmission.
- Spares peripheral prostaglandins, explaining minimal anti-inflammatory and platelet effects.
- Serotonergic modulation
- Enhances descending 5-HT3 anti-nociceptive pathways in the spinal cord.
- Endocannabinoid interaction
- Metabolite p-aminophenol conjugates with arachidonic acid forming AM404, an anandamide re-uptake inhibitor acting on CB1 receptors—attenuates central pain perception.
- TRPA1 channel blockade – Reduces transmission in pain-sensitive neurons.
This composite action lowers the hypothalamic set-point in fever and elevates pain threshold without gastrointestinal or renal vascular compromise typical of NSAIDs.
ADOL 500mg Interactions ADOL 500mg
While paracetamol is generally well tolerated, certain pharmacokinetic or pharmacodynamic interactions warrant caution:
- Hepatic enzyme inducers (e.g., rifampicin, carbamazepine, phenytoin, phenobarbital, St John’s wort)
- Accelerate CYP2E1-mediated conversion to the hepatotoxic metabolite NAPQI → ↑ risk of liver injury at therapeutic doses.
- Warfarin & other coumarin anticoagulants
- Regular paracetamol (> 2 g/day for ≥ 3 days) potentiates INR; monitor clotting or adjust warfarin dose.
- Isoniazid – Competitive metabolism heightens hepatotoxicity.
- Alcohol (chronic ´)
- Chronic intake induces CYP2E1; acute heavy drinking depletes glutathione → both increase susceptibility to hepatotoxicity.
- Probenecid – Nearly doubles paracetamol AUC by inhibiting glucuronidation; halve paracetamol dose if long-term concomitance.
- Metoclopramide or domperidone – Accelerate gastric emptying; not relevant to rectal route but may alter systemic exposure if alternating with oral forms.
- Cholestyramine – Binds drug in the gut; negligible effect rectally but avoid giving orally within 1 h.
- Lamotrigine – Paracetamol may enhance glucuronidation, lowering lamotrigine levels; monitor seizure control.
Always review full medication profiles, including OTC and herbal agents, before prolonged paracetamol therapy.
Dosage of ADOL 500mg
Below are evidence-based rectal dosing regimens; adapt to local guidelines and patient factors:
- Adults & adolescents ≥ 12 y
- 500 mg–1 g every 4–6 h as needed.
- Maximum 4 g in 24 h (8 suppositories).
- Children 6–11 y – 250–500 mg every 6 h; max 60 mg/kg/day.
- Children 3–5 y – 250 mg every 6 h; max 60 mg/kg/day.
- Children 1–2 y – 125 mg every 6 h; max 60 mg/kg/day (use appropriately dosed paediatric suppository).
- Infants 3–11 mo – 60–125 mg every 6–8 h; specialist advice required.
- Elderly – No dose adjustment if liver & renal function normal; consider reduced frequency if frail or low body weight.
- Hepatic impairment – Reduce total daily dose to ≤ 2 g and extend dosing interval to 6–8 h.
- Renal impairment (CrCl < 30 mL/min) – Standard single dose but interval ≥ 6 h; avoid consecutive high doses.
- Dose calculation tip – In paediatrics, base on weight: 15 mg/kg per dose up to 60 mg/kg/day.
Important: Do not exceed recommended limits; cumulative paracetamol from combination cold/flu products counts toward the daily ceiling.
Possible side effects of ADOL 500mg
At therapeutic doses, paracetamol’s adverse-event profile is benign, yet no drug is risk-free. Monitor for:
- Common (< 1 %)
- Local rectal discomfort, transient burning, or urge to defecate.
- Uncommon (0.1–1 %)
- Pruritus, erythema, urticaria.
- Nausea or abdominal cramps (rare, often dose-related).
- Rare (< 0.1 %)
- Hypersensitivity reactions: angio-oedema, bronchospasm—higher risk in NSAID-asthma triad.
- Hepatic enzyme elevation after prolonged high doses.
- Thrombocytopenia, neutropenia, pancytopenia—idiosyncratic, reversible on withdrawal.
- Very rare (< 0.01 %)
- Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN); discontinue immediately if mucocutaneous lesions appear.
- Acute generalized exanthematous pustulosis (AGEP).
- Toxicity (overdose)
- Phase I (0–24 h): anorexia, nausea, diaphoresis → often mild.
- Phase II (24–72 h): RUQ pain, rising ALT/AST.
- Phase III (72–96 h): fulminant hepatic failure, coagulopathy, encephalopathy.
- Phase IV (4–14 d): recovery or death/transplant.
Any jaundice, dark urine, or severe abdominal pain warrants urgent medical review, regardless of dose taken.
ADOL 500mg Contraindications ADOL 500mg
Although broad safety supports widespread OTC use, treatment is contraindicated in the following circumstances:
- Known hypersensitivity to paracetamol or any excipients (e.g., hard fat suppository base).
- Severe hepatic impairment (Child-Pugh C), active liver disease, or acute viral hepatitis.
- Severe haemolytic anaemia or G6PD deficiency where oxidative stress may precipitate crisis.
- Rectal pathology – Anal fissures, proctitis, recent colorectal surgery, or active haemorrhoids causing pain/bleeding.
- Repeated high-dose alcohol misuse because of depleted glutathione stores.
- Dehydration & malnutrition (e.g., anorexia, eating disorders, cachexia) where glutathione reserves are low.
- Premature neonates (< 37 weeks gestation) without specialist supervision due to immature hepatic enzymes.
Clinicians should weigh risk–benefit in moderate hepatic or renal impairment and consider lower total daily doses.
Storage of ADOL 500mg
Proper storage preserves potency and microbial integrity:
- Temperature: Store below 25 °C (77 °F). Short excursions to 30 °C tolerated, but avoid prolonged heat that may soften suppositories.
- Humidity: Keep in original heat-sealed blister until use; moisture may erode the suppository base.
- Light: Paracetamol is photo-stable, yet opaque packaging shields from oxidation.
- Handling hints
- Do not refrigerate for extended periods (> 1 month) to prevent fat bloom and brittleness.
- For travel, transport in an insulated pouch if ambient > 35 °C.
- Child safety: Store out of sight and reach; rectal suppositories resemble confectionery.
- Shelf-life: Typically 36 months unopened. Check expiry date; discard if discoloured, rancid-smelling, or fissured.
- Disposal: Return unused or expired medicines to a pharmacy take-back program; do not flush or burn.
Following these guidelines ensures each suppository delivers its full therapeutic promise when required.
ADOL 500mg features an exceptional active ingredient renowned for its potent effects, comprising Paracetamol. This powerful formulation provides a superior solution for addressing diverse health concerns. With 500mg/Suppository concentration and an easily manageable Rectal Suppositories, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ADOL 500mg .
Welcome to Dwaey, specifically on ADOL 500mg page.
This medicine contains an important and useful components, as it consists of Paracetamol.
ADOL 500mg is available in the market in concentration 500mg/Suppository and in the form of Rectal Suppositories.
JULPHAR (GULF PHARMACEUTICAL INDUSTRIES) is the producer of ADOL 500mg and it is imported from UAE,
The most popular alternatives of ADOL 500mg are listed downward .
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Active Substance
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JULPHAR (GULF PHARMACEUTICAL INDUSTRIES)
Frequently Asked Questions
ADOL 500mg should be stored according to the instructions provided by JULPHAR (GULF PHARMACEUTICAL INDUSTRIES).
In general, it is recommended to store ADOL 500mg in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ADOL 500mg may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ADOL 500mg for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ADOL 500mg. Some medications, including
ADOL 500mg, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ADOL 500mg, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ADOL 500mg without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ADOL 500mg if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ADOL 500mg during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 500mg/Suppository,
and the specific recommendations of JULPHAR (GULF PHARMACEUTICAL INDUSTRIES).
The effects of ADOL 500mg on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 500mg/Suppository, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ADOL 500mg with or without food may vary depending on the medication
and the recommendations of JULPHAR (GULF PHARMACEUTICAL INDUSTRIES). Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ADOL 500mg in children or elderly individuals may depend on various factors, including
the specific medication, type Rectal Suppositories, and the recommendations of JULPHAR (GULF PHARMACEUTICAL INDUSTRIES). Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ADOL 500mg in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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