ADIPRIN-EC 100mg Tablets/Enteric-coated

What is ADIPRIN-EC 100mg

ADIPRIN-EC 100mg is an enteric-coated tablet formulation that contains Aspirin (Acetylsalicylic Acid) as its active ingredient. It is primarily used as an antiplatelet agent to help prevent blood clots, which can lead to heart attacks or strokes. The "EC" stands for enteric-coated, meaning the tablet has a special coating that prevents it from dissolving in the acidic environment of the stomach. Instead, it dissolves in the more alkaline environment of the intestines, reducing the risk of gastric irritation.

• Classified as a non-steroidal anti-inflammatory drug (NSAID) with antiplatelet properties.
• Commonly used in low doses (like 100mg) for long-term cardiovascular protection.
• Indicated for the secondary prevention of cardiovascular events such as myocardial infarction, ischemic stroke, and transient ischemic attacks.
• Also used prophylactically in certain high-risk individuals, such as those with diabetes, hypertension, or peripheral arterial disease.

Due to its enteric coating, ADIPRIN-EC is less likely to cause gastrointestinal side effects compared to regular aspirin tablets, making it suitable for long-term daily use under medical supervision.

How to use ADIPRIN-EC 100mg

To achieve maximum effectiveness while minimizing side effects, it is important to use ADIPRIN-EC 100mg exactly as directed by your healthcare provider.

• Dosage: Usually taken once daily, preferably at the same time each day.
• Administration: Swallow the tablet whole with water. Do not crush, chew, or break the tablet, as this will damage the enteric coating and increase the risk of stomach irritation.
• Timing: It may be taken with or without food, but taking it after a meal may help further reduce stomach discomfort.
• Missed Dose: If you miss a dose, take it as soon as you remember. Skip the missed dose if it is almost time for your next dose—do not double up.
• Regular Monitoring: Periodic blood tests may be recommended to monitor bleeding risk and assess effectiveness.

Always inform your doctor about all other medications, supplements, and conditions before starting ADIPRIN-EC, and never stop taking it abruptly without consulting your physician, especially if prescribed for cardiovascular protection.

Mode of Action ADIPRIN-EC 100mg

Aspirin, the active ingredient in ADIPRIN-EC 100mg, works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins and thromboxane. This mechanism underpins both its anti-inflammatory and antiplatelet actions.

• COX Inhibition: Irreversibly blocks COX-1 in platelets, preventing the formation of thromboxane A2—a compound that stimulates platelet aggregation and vasoconstriction.
• Antiplatelet Effect: Reduces the stickiness of platelets, preventing them from clumping together to form harmful clots in arteries.
• Irreversible Binding: A single dose of aspirin affects the platelets for their entire lifespan (7–10 days), which explains its long-lasting effect despite its short half-life.
• Enteric Coating: Designed to bypass the stomach and dissolve in the small intestine, minimizing irritation to gastric mucosa.

This antiplatelet mechanism is especially important in patients at risk of cardiovascular events such as heart attacks and strokes, as it significantly reduces the chances of clot formation in the arteries.

ADIPRIN-EC 100mg Interactions ADIPRIN-EC 100mg

ADIPRIN-EC 100mg can interact with several medications, which may increase the risk of bleeding, reduce the efficacy of other drugs, or potentiate side effects. Always inform your doctor about all medications you are taking.

• Anticoagulants (e.g., Warfarin, Heparin): Increased risk of bleeding when used together.
• NSAIDs (e.g., Ibuprofen, Naproxen): May reduce aspirin’s cardioprotective effect and increase gastrointestinal side effects.
• SSRIs (e.g., Sertraline, Fluoxetine): Increased risk of gastrointestinal bleeding.
• ACE Inhibitors and ARBs: May reduce renal function when combined with aspirin, especially in patients with kidney issues.
• Methotrexate: Aspirin can increase methotrexate toxicity by reducing renal clearance.
• Corticosteroids (e.g., Prednisone): Additive risk of GI ulceration and bleeding.
• Alcohol: Concurrent use increases the risk of stomach bleeding.

Close monitoring and possible dosage adjustments may be required when ADIPRIN-EC is used with any of the above medications.

Dosage of ADIPRIN-EC 100mg

The dosage of ADIPRIN-EC 100mg depends on the condition being treated and the individual patient profile. It is generally used as a low-dose, long-term therapy for cardiovascular protection.

• Standard Dose: 100mg once daily for most adults for prevention of heart attacks, strokes, or following certain cardiovascular interventions (e.g., angioplasty, stenting).
• Primary Prevention: May be considered in select patients at high cardiovascular risk but should be carefully evaluated due to bleeding risk.
• Secondary Prevention: Strong evidence supports daily use in individuals with a history of myocardial infarction, ischemic stroke, or established peripheral arterial disease.
• Special Populations:
  • Elderly: Use with caution due to increased risk of gastrointestinal bleeding and kidney impairment.
  • Renal/Hepatic Impairment: Dose adjustments may be required; use only under medical supervision.

Never alter your dose or discontinue the medication without consulting your healthcare provider, as abrupt cessation can lead to rebound platelet activity and increased risk of clot formation.

Possible side effects of ADIPRIN-EC 100mg

While ADIPRIN-EC 100mg is generally well tolerated at low doses, it can still cause side effects in some individuals. These may range from mild to serious.

• Common Side Effects:
  • Gastrointestinal discomfort or nausea (less likely due to enteric coating)
  • Heartburn or indigestion
  • Mild headache or dizziness
• Less Common But Serious Effects:
  • Bleeding (e.g., gums, nosebleeds, or gastrointestinal bleeding)
  • Allergic reactions (e.g., rash, swelling, itching)
  • Ulceration or perforation of the stomach lining (rare with enteric-coated forms)
• Rare Side Effects:
  • Reye's syndrome (especially in children with viral infections – hence avoided in children)
  • Bronchospasm in aspirin-sensitive asthmatics
  • Liver enzyme abnormalities

Seek immediate medical attention if you experience signs of internal bleeding (black/tarry stools, vomiting blood) or allergic reactions (difficulty breathing, swelling of the face/lips).

ADIPRIN-EC 100mg Contraindications ADIPRIN-EC 100mg

ADIPRIN-EC 100mg should not be used in certain medical conditions due to the risk of severe adverse effects.

• Hypersensitivity: Known allergy to aspirin or other NSAIDs.
• Active bleeding disorders: Including hemophilia or gastrointestinal bleeding.
• Peptic ulcer disease: Particularly active or recurrent ulcers.
• Severe hepatic or renal impairment
• Asthma: Especially if aspirin-induced or NSAID-sensitive asthma has been diagnosed.
• Children and teenagers: Should not be used in those under 16 years for viral illnesses due to the risk of Reye’s syndrome.
• Third trimester of pregnancy: Aspirin can affect fetal cardiovascular and renal function and may delay labor or cause bleeding.

Always consult your doctor to evaluate the risks and benefits of using this medication based on your individual health profile.

Storage of ADIPRIN-EC 100mg

Proper storage of ADIPRIN-EC 100mg is essential to maintain its effectiveness and prevent degradation.

• Temperature: Store at room temperature between 15°C to 25°C (59°F to 77°F).
• Humidity: Keep in a dry place. Protect from excessive moisture and humidity.
• Light: Store away from direct sunlight and in the original blister packaging until use.
• Child Safety: Keep out of reach and sight of children to prevent accidental ingestion.
• Expiry: Do not use beyond the expiration date printed on the packaging. Dispose of expired tablets safely.

Do not transfer the tablets to another container, as this may expose them to air or moisture, compromising the enteric coating.