LISAFEN 400 mg/3 ml Solution for injection

What is LISAFEN 400 mg/3 ml

LISAFEN 400 mg/3 ml is a parenteral (injectable) form of Ibuprofen, a well-known nonsteroidal anti-inflammatory drug (NSAID). It is used for the rapid relief of moderate pain and inflammation in conditions where oral administration is not feasible or when faster onset of action is required. Each 3 ml ampoule contains 400 mg of Ibuprofen, typically administered intravenously or intramuscularly under medical supervision.

• Active Ingredient: Ibuprofen 400 mg per 3 ml ampoule
• Drug Class: NSAID – Nonsteroidal Anti-Inflammatory Drug
• Main Uses: Acute pain, postoperative pain, musculoskeletal inflammation, fever
• Formulation: Sterile solution suitable for IV or IM injection

LISAFEN is often used in clinical settings like hospitals or outpatient surgical centers for immediate pain management.

How to use LISAFEN 400 mg/3 ml

LISAFEN injection should only be administered by qualified healthcare professionals.

• Intravenous (IV) Use: Administer slowly over 30 minutes as an infusion diluted in compatible IV fluid
• Intramuscular (IM) Use: Inject deep into the gluteal muscle
• Do Not Administer as a Bolus: Must not be given undiluted as a rapid IV push
• Aseptic Technique: Strict sterile technique must be followed during preparation and administration

Never self-administer. Always follow physician instructions and product-specific dilution guidelines.

Mode of Action LISAFEN 400 mg/3 ml

Ibuprofen works by inhibiting the cyclooxygenase enzymes (COX-1 and COX-2), which are involved in the synthesis of prostaglandins — chemicals that mediate inflammation, pain, and fever.

• Anti-inflammatory: Reduces swelling and tissue inflammation
• Analgesic: Provides relief from moderate pain (e.g., post-op pain, soft tissue injury)
• Antipyretic: Reduces fever by acting on the hypothalamus

Because it is given via injection, LISAFEN provides a more rapid onset of action compared to oral ibuprofen.

LISAFEN 400 mg/3 ml Interactions LISAFEN 400 mg/3 ml

Ibuprofen may interact with a range of medications. Clinical monitoring is advised if used with:

• Anticoagulants: May increase risk of bleeding (e.g., warfarin)
• Antihypertensives: May reduce effectiveness of ACE inhibitors, beta-blockers
• Diuretics: Can diminish diuretic effect, increase renal risks
• Other NSAIDs: Avoid concurrent use to minimize gastrointestinal and renal side effects
• SSRIs: May increase risk of bleeding

Inform your healthcare provider of all medications you’re taking, including over-the-counter drugs.

Dosage of LISAFEN 400 mg/3 ml

• Adults: 400–800 mg every 6–8 hours as needed; maximum daily dose: 2400 mg
• Children: Not typically recommended unless specified by a pediatric specialist
• Elderly: Use with caution; may require lower doses

Dosage must be individualized based on patient’s condition, weight, and clinical response. Avoid prolonged use.

Possible side effects of LISAFEN 400 mg/3 ml

As with all NSAIDs, LISAFEN may cause a range of side effects, especially with prolonged use or high doses.

• Common: Nausea, dizziness, headache, injection site irritation
• GI Effects: Stomach pain, dyspepsia, risk of ulcers or bleeding
• Renal: Fluid retention, elevated creatinine, decreased kidney function
• Cardiovascular: Increased risk of hypertension, thrombotic events (with long-term use)
• Allergic: Rash, bronchospasm, anaphylaxis (rare)

Seek immediate medical help if severe allergic reactions, chest pain, or gastrointestinal bleeding symptoms occur.

LISAFEN 400 mg/3 ml Contraindications LISAFEN 400 mg/3 ml

• Known allergy to ibuprofen, aspirin, or other NSAIDs
• History of peptic ulcer disease or gastrointestinal bleeding
• Severe liver or kidney impairment
• Uncontrolled heart failure or hypertension
• Third trimester of pregnancy

Use with caution in patients with asthma or bleeding disorders.

Storage of LISAFEN 400 mg/3 ml

• Store at temperatures below 25°C (77°F)
• Protect from light and moisture
• Do not freeze
• Keep ampoules in the original packaging until ready to use
• Keep out of reach of children

Do not use the ampoule if it appears cloudy or contains particles. Discard after opening.