LINEZOLID DENK 2mg/ml solution for infusion

What is LINEZOLID DENK 2mg/ml

LINEZOLID DENK 2 mg/ml is a sterile intravenous solution used to treat serious bacterial infections caused by Gram-positive bacteria, including those resistant to multiple antibiotics. Each 300 ml LDPE bag contains a total of 600 mg of Linezolid, an oxazolidinone-class antibiotic that works by preventing bacterial growth. Manufactured by Denk Pharma, it is typically used in hospitals to treat life-threatening infections when oral therapy is inappropriate.

• Generic: Linezolid
• Strength: 2 mg per 1 ml (i.e., 600 mg in 300 ml)
• Form: Ready-to-use IV infusion bag
• Indications: Pneumonia (community-acquired and nosocomial), skin and soft tissue infections, and infections caused by MRSA and VRE

Linezolid is often reserved for use when other antibiotics have failed or when pathogens show resistance to standard therapies.

How to use LINEZOLID DENK 2mg/ml

LINEZOLID DENK is intended for intravenous infusion only and must be administered in a hospital or clinical setting by healthcare professionals. The solution is infused over 30 to 120 minutes depending on institutional protocols.

• Dosage: 600 mg every 12 hours (one 300 ml bag)
• Infusion duration: Minimum 30 minutes; do not use bolus injection
• Preparation: Do not dilute or mix with other IV drugs
• Administration: Via a central or peripheral IV line

Ensure the bag is not damaged or discolored before use. Discard any unused portion after the infusion.

Mode of Action LINEZOLID DENK 2mg/ml

Linezolid works by inhibiting bacterial protein synthesis. It binds to the bacterial 50S ribosomal subunit and prevents the formation of a functional 70S initiation complex, a critical component in the replication process.

• Target: 23S rRNA of the 50S ribosome
• Mechanism: Prevents the formation of the initiation complex in protein synthesis
• Effect: Bacteriostatic against staphylococci and enterococci; bactericidal against most streptococci

This novel mechanism of action is effective even against organisms resistant to other major antibiotic classes.

LINEZOLID DENK 2mg/ml Interactions LINEZOLID DENK 2mg/ml

Due to its weak, reversible MAO-inhibiting properties, Linezolid can interact with a range of medications and food substances.

• SSRIs and SNRIs: Increased risk of serotonin syndrome
• Adrenergic agents (e.g., epinephrine, pseudoephedrine): Risk of hypertension
• MAOIs: Contraindicated within 14 days of MAOI therapy
• Tyramine-rich foods: Aged cheese, wine, fermented soy—risk of hypertensive crisis

Close monitoring is essential when combining Linezolid with serotonergic or adrenergic drugs.

Dosage of LINEZOLID DENK 2mg/ml

The standard dosage for adults is 600 mg administered intravenously every 12 hours. Pediatric dosing depends on body weight.

• Adults: 600 mg (1 infusion bag) every 12 hours
• Children: 10 mg/kg every 8–12 hours (maximum 600 mg)
• Renal or hepatic impairment: No dose adjustment necessary, but monitor during prolonged therapy
• Maximum duration: Up to 28 days (IV and oral combined)

Always follow your healthcare provider’s instructions for dosage and treatment duration.

Possible side effects of LINEZOLID DENK 2mg/ml

While Linezolid is generally effective and well-tolerated, some side effects may occur, particularly with prolonged use.

• Common: Diarrhea, nausea, vomiting, headache
• Less common: Thrombocytopenia, anemia, fungal infections
• Serious: Lactic acidosis, optic neuropathy, peripheral neuropathy, serotonin syndrome

Patients receiving treatment beyond 14 days should have their blood counts and visual function monitored regularly.

LINEZOLID DENK 2mg/ml Contraindications LINEZOLID DENK 2mg/ml

• Known hypersensitivity to Linezolid
• Concurrent use with MAOIs or serotonergic agents (unless under close supervision)
• Uncontrolled hypertension
• Hyperthyroidism
• History of serotonin syndrome

Caution is advised in patients with bone marrow suppression or a history of seizures.

Storage of LINEZOLID DENK 2mg/ml

• Store at 20–25°C (68–77°F); excursions allowed between 15–30°C
• Do not freeze or expose to excessive heat
• Protect from direct light
• Use immediately after opening

Store in the original LDPE overwrap until ready to use. Keep out of reach of children.