ADCITAN 500mg Tablets/Film-coated

What is ADCITAN 500mg

ADCITAN 500 mg is a film-coated tablet formulation containing Levetiracetam, an antiepileptic drug used primarily to control seizures. It is supplied in packs of 100 tablets, arranged in 10 tablets per blister and 10 blisters per pack. This medicine is intended for oral administration and is widely prescribed for epilepsy management.

Levetiracetam is used to treat several types of seizures including:

• Partial-onset seizures (with or without secondary generalization) in adults and children.
• Myoclonic seizures, especially in patients with juvenile myoclonic epilepsy.
• Generalized tonic-clonic seizures.

It is often prescribed as adjunctive therapy but can also be used as monotherapy depending on the patient’s condition. ADCITAN 500 mg helps reduce seizure frequency and severity, improving patient quality of life and minimizing the risk of seizure-related injury.

How to use ADCITAN 500mg

Using ADCITAN 500 mg correctly is essential for effective seizure control and minimizing adverse effects:

• Administration: Take the tablets orally, with or without food, as directed by your healthcare provider.
• Consistency: Take the medication at the same times each day to maintain stable blood levels.
• Swallow whole: Do not crush, chew, or break the tablets to avoid altering the release profile.
• Missed doses: If you miss a dose, take it as soon as possible unless it is almost time for your next dose. Do not double the dose.
• Duration: Antiepileptic therapy is often long-term; never stop or adjust the dose without consulting your doctor.
• Monitoring: Regular follow-up visits to assess seizure frequency and side effects are crucial.
• Adjustments: Dose adjustments may be necessary based on clinical response and kidney function.

Mode of Action ADCITAN 500mg

Levetiracetam, the active ingredient in ADCITAN 500 mg, has a distinctive mechanism of action compared to other antiepileptics:

• Binding to SV2A protein: It selectively binds to the synaptic vesicle protein 2A (SV2A), which plays a key role in neurotransmitter release. This modulates synaptic transmission and reduces abnormal electrical activity in the brain that leads to seizures.
• Reduction of neuronal hypersynchronization: Levetiracetam dampens excessive neuronal firing and synchronization that cause epileptic discharges.
• Inhibition of calcium currents: It inhibits N-type calcium channels, reducing the release of excitatory neurotransmitters.
• Neuroprotective effects: Some evidence suggests levetiracetam protects neurons from excitotoxic damage.

This unique mode of action contributes to its efficacy across multiple seizure types and a generally favorable side effect profile.

ADCITAN 500mg Interactions ADCITAN 500mg

Levetiracetam is known for a low risk of drug interactions, but some important points should be considered:

• Minimal metabolism: Levetiracetam is minimally metabolized by the liver, reducing interactions with drugs metabolized by cytochrome P450 enzymes.
• Other antiepileptics: It can be used safely with many AEDs such as carbamazepine, phenytoin, valproate, and lamotrigine without significant interaction.
• Oral contraceptives: Does not reduce the effectiveness of hormonal contraceptives, unlike some other antiepileptic drugs.
• CNS depressants: Concomitant use with alcohol, benzodiazepines, or opioids may increase sedation and dizziness.
• Renal function modifiers: Since levetiracetam is excreted primarily by the kidneys, drugs affecting renal function may alter its clearance.

Inform your healthcare provider of all medications and supplements to avoid unexpected effects.

Dosage of ADCITAN 500mg

Dosage varies depending on patient age, renal function, and seizure type. Typical adult dosing guidelines include:

• Starting dose: Usually 500 mg twice daily.
• Titration: The dose may be increased by 500 mg twice daily every 2 weeks based on clinical response and tolerability.
• Maintenance dose: Typically ranges between 1000 mg and 3000 mg per day, divided into two doses.
• Maximum dose: Up to 3000 mg daily depending on clinical judgment.
• Renal impairment: Dose reduction is necessary in patients with decreased renal function to prevent accumulation.
• Pediatric dosing: Weight-based and age-adjusted; requires specialist consultation.

Always follow your doctor’s prescribed dose and schedule carefully.

Possible side effects of ADCITAN 500mg

While levetiracetam is generally well tolerated, side effects can occur. These include:

• Common side effects:
• Drowsiness and fatigue
• Dizziness or headache
• Weakness
• Increased infection risk (e.g., respiratory infections)
• Psychiatric side effects:
• Irritability or agitation
• Depression or mood swings
• Anxiety or nervousness
• Rarely, psychotic symptoms or suicidal thoughts
• Gastrointestinal effects: Nausea, vomiting, and diarrhea.
• Serious adverse effects (rare):
• Severe allergic reactions
• Skin rash or Stevens-Johnson syndrome
• Blood abnormalities such as neutropenia or thrombocytopenia

Any unusual or severe symptoms should be reported to a healthcare provider promptly.

ADCITAN 500mg Contraindications ADCITAN 500mg

Contraindications and precautions include:

• Known hypersensitivity: Allergy to levetiracetam or any formulation excipients.
• Severe renal impairment: Without appropriate dose adjustment, risk of toxicity increases.
• Psychiatric conditions: Use with caution in patients with a history of depression, suicidal ideation, or psychosis.
• Pregnancy and breastfeeding: Only if the potential benefit justifies the risk; consult your doctor.

Always disclose your full medical history to your healthcare provider before starting treatment.

Storage of ADCITAN 500mg

Proper storage ensures the stability and effectiveness of ADCITAN tablets:

• Store in a cool, dry place below 30°C (86°F).
• Keep tablets in their original blister pack until use to protect from moisture and light.
• Keep out of reach of children and pets.
• Do not use beyond the expiration date on the package.
• Dispose of unused or expired medication safely, following local regulations or pharmacy advice.