ADCITAN 1000mg Tablets/Film-coated

What is ADCITAN 1000mg

ADCITAN 1000 mg is a film-coated tablet formulation of Levetiracetam, an anticonvulsant medication widely used in the management of epilepsy. It is designed for oral administration and comes in 100 tablets per pack (10 tablets per blister, 10 blisters).

This medication is primarily indicated for the treatment of partial-onset seizures, myoclonic seizures, and generalized tonic-clonic seizures in adults and children. ADCITAN works to reduce the frequency and severity of seizures, improving patient quality of life.

• Used as monotherapy or adjunctive therapy in epilepsy management.
• Effective in various types of seizures including partial-onset and generalized seizures.
• Known for a favorable safety and tolerability profile compared to older antiepileptic drugs.

Levetiracetam's oral bioavailability is nearly 100%, allowing predictable absorption, and it has minimal interactions with other antiepileptic or concomitant drugs.

How to use ADCITAN 1000mg

Proper administration of ADCITAN 1000 mg is essential for optimal seizure control and minimizing side effects.

• Dosage form: Take the tablet orally with or without food as prescribed by your healthcare provider.
• Consistency: It is important to take ADCITAN at the same time every day to maintain stable blood levels.
• Swallow whole: Tablets should be swallowed whole with water; do not crush or chew as it may alter drug release.
• Missed dose: If a dose is missed, take it as soon as remembered unless it is near the time for the next dose. Do not double doses.
• Duration: Treatment duration is typically long-term and individualized depending on seizure control and clinical response.
• Medical supervision: Never stop or adjust the dose without consulting your healthcare provider to avoid increased seizure risk.

Regular monitoring of seizure frequency and side effects is recommended during treatment.

Mode of Action ADCITAN 1000mg

Levetiracetam, the active ingredient in ADCITAN, exerts its antiepileptic effects through unique mechanisms, distinct from other anticonvulsants.

• Synaptic vesicle protein 2A (SV2A) binding: Levetiracetam binds selectively to SV2A, a protein involved in neurotransmitter release, modulating synaptic transmission.
• Inhibition of neuronal hypersynchronization: By modulating SV2A, it reduces abnormal electrical activity that leads to seizures.
• Calcium channel modulation: It may inhibit N-type calcium channels, decreasing excitatory neurotransmitter release.
• Neuroprotective effects: Shows some protective action on neurons against excitotoxicity.

This unique mode of action contributes to its efficacy across multiple seizure types and its generally favorable safety profile.

ADCITAN 1000mg Interactions ADCITAN 1000mg

Levetiracetam has a low potential for pharmacokinetic interactions, but certain considerations remain important:

• Minimal hepatic metabolism: Unlike many antiepileptics, levetiracetam is not extensively metabolized by cytochrome P450 enzymes, reducing drug interaction risk.
• Other antiepileptic drugs (AEDs): It can be safely combined with drugs such as carbamazepine, valproate, phenytoin, and lamotrigine without significant interaction.
• Oral contraceptives: Unlike some AEDs, levetiracetam does not reduce the efficacy of hormonal contraceptives.
• CNS depressants: Concurrent use with sedatives or alcohol may enhance CNS depression; caution advised.
• Renal function: Drugs affecting renal function can influence levetiracetam elimination since it is primarily excreted unchanged in urine.

Always inform your healthcare provider of all medications you are taking to avoid unexpected interactions.

Dosage of ADCITAN 1000mg

Dosage should be tailored based on patient age, renal function, seizure type, and response. General guidelines include:

• Adults and adolescents (≥16 years): Initial dose usually starts at 500 mg twice daily, increased to 1000 mg twice daily based on clinical response.
• Maximum dose: Up to 3000 mg/day in divided doses may be used depending on tolerability and efficacy.
• Renal impairment: Dose adjustments are essential in patients with impaired kidney function, based on creatinine clearance.
• Children: Pediatric dosing varies with weight and age; consult pediatric-specific guidelines.

Regular assessment is necessary to balance seizure control and side effects, and gradual titration is recommended.

Possible side effects of ADCITAN 1000mg

Levetiracetam is generally well tolerated, but side effects can occur:

• Common side effects:
• Drowsiness or fatigue
• Dizziness
• Headache
• Weakness
• Infection (upper respiratory tract infections)
• Psychiatric effects:
• Irritability
• Depression or mood changes
• Anxiety
• Rarely, psychosis or suicidal thoughts
• Gastrointestinal effects: Nausea, vomiting, and diarrhea
• Serious but rare: Severe allergic reactions, severe skin reactions (e.g., Stevens-Johnson syndrome), blood dyscrasias

Any severe or persistent side effects warrant immediate medical attention.

ADCITAN 1000mg Contraindications ADCITAN 1000mg

Contraindications and precautions for levetiracetam include:

• Hypersensitivity: Known allergy to levetiracetam or any component of the formulation.
• Severe renal impairment without dose adjustment: Risk of accumulation and toxicity.
• Pregnancy and breastfeeding: Use only if benefits outweigh risks, as safety data is limited.
• Psychiatric disorders: Use cautiously in patients with a history of depression, suicidal ideation, or psychosis.

Careful assessment of risks and benefits is crucial before initiation.

Storage of ADCITAN 1000mg

Proper storage is important to maintain the stability and effectiveness of ADCITAN tablets:

• Store in a cool, dry place at temperatures below 30°C (86°F).
• Keep the tablets in their original blister pack until use to protect from moisture and light.
• Keep out of reach of children and pets.
• Do not use tablets past the expiration date indicated on the packaging.
• Dispose of unused or expired medication according to local regulations or pharmacy guidelines.

Following these storage instructions helps ensure drug integrity and patient safety.