ADAZIO 200mg Tablets/Film-coated

What is ADAZIO 200mg

ADAZIO 200 mg is a film-coated tablet containing Quetiapine fumarate, an atypical antipsychotic medication. It's primarily prescribed for adults to treat:

• Schizophrenia: A mental disorder characterized by distorted thinking, perceptions, emotions, language, sense of self, and behavior.
• Bipolar Disorder: Including manic episodes, depressive episodes, and maintenance therapy to prevent recurrence.
• Major Depressive Disorder (adjunct therapy): In combination with antidepressants for treatment-resistant depression.

Quetiapine works by modulating neurotransmitters in the brain, particularly dopamine and serotonin, to help restore balance and alleviate symptoms associated with these mental health conditions.

How to use ADAZIO 200mg

Administration Guidelines:

• Dosage: Take as prescribed by your healthcare provider. The dosage may vary based on the condition being treated.
• Timing: Depending on the formulation, it may be taken once daily at bedtime or divided into two doses.
• With or Without Food: ADAZIO can be taken with or without food. However, consistency is key.
• Swallow Whole: Do not crush, chew, or split the tablet.
• Missed Dose: If you miss a dose, take it as soon as you remember. If it's close to the next dose, skip the missed one. Do not double up.

Always follow your doctor's instructions and do not adjust the dose without consulting them.

Mode of Action ADAZIO 200mg

Pharmacodynamics:

• Dopamine Receptor Antagonism: Quetiapine blocks D2 receptors, reducing positive symptoms of schizophrenia.
• Serotonin Receptor Antagonism: Blocks 5-HT2A receptors, which may improve negative symptoms and cognitive deficits.
• Histamine and Adrenergic Receptor Antagonism: Leads to sedative effects and may cause orthostatic hypotension.

This multifaceted receptor activity contributes to its efficacy in treating various psychiatric conditions.

ADAZIO 200mg Interactions ADAZIO 200mg

Drug Interactions:

• CYP3A4 Inhibitors: Medications like ketoconazole can increase quetiapine levels, necessitating dose adjustments.
• CYP3A4 Inducers: Drugs like phenytoin may decrease quetiapine effectiveness.
• Alcohol: Can enhance sedative effects; avoid concurrent use.
• Antihypertensive Agents: May potentiate blood pressure-lowering effects.
• QT-Prolonging Drugs: Concurrent use may increase the risk of arrhythmias.

Always inform your healthcare provider about all medications and supplements you're taking to avoid potential interactions.

Dosage of ADAZIO 200mg

Recommended Dosages:

• Schizophrenia: Start with 25 mg twice daily, increasing to 300-400 mg daily in divided doses. Maximum dose: 800 mg/day.
• Bipolar Mania: Begin with 100 mg/day, increasing to 400-800 mg/day in divided doses.
• Bipolar Depression: 50 mg on day 1, increasing to 300 mg/day by day 4.
• Major Depressive Disorder (adjunct): 50 mg on day 1, increasing to 150-300 mg/day.

Dosage may vary based on individual health conditions and response to therapy. Always adhere to your doctor's recommendations.

Possible side effects of ADAZIO 200mg

Common Side Effects:

• Drowsiness
• Dizziness
• Dry mouth
• Constipation
• Weight gain

Serious Side Effects:

• Orthostatic hypotension
• Seizures
• Neuroleptic malignant syndrome
• Tardive dyskinesia
• Increased blood sugar levels

If you experience any severe or persistent side effects, seek medical attention immediately.

ADAZIO 200mg Contraindications ADAZIO 200mg

Do Not Use ADAZIO 200 mg If:

• You are allergic to quetiapine or any other ingredients in the tablet.
• You are taking medications that prolong the QT interval.
• You have a history of severe cardiovascular disease.
• You are under 18 years of age (safety and efficacy not established).

Consult your doctor to ensure ADAZIO 200 mg is safe for you, especially if you have underlying health conditions.

Storage of ADAZIO 200mg

Storage Instructions:

• Store at room temperature (15°C to 30°C).
• Keep the tablets in their original packaging to protect from moisture and light.
• Keep out of reach of children.
• Do not use after the expiration date on the packaging.

Proper storage ensures the medication maintains its efficacy and safety.