ACULAR LS 0.4% Ophthalmic Solution Eye Drops (Solution)

What is ACULAR LS 0.4% Ophthalmic Solution

ACULAR LS 0.4% Ophthalmic Solution is a nonsteroidal anti-inflammatory drug (NSAID) formulated for topical ocular use. Its active ingredient, ketorolac tromethamine, is designed to alleviate ocular pain and inflammation. Specifically, ACULAR LS is indicated for:

• Reducing ocular pain and burning/stinging sensations following corneal refractive surgery.

This medication is supplied in a 5 mL dropper bottle, containing a sterile solution of ketorolac tromethamine at a concentration of 0.4% (4 mg/mL) :contentReference[oaicite:4]{index=4}.

How to use ACULAR LS 0.4% Ophthalmic Solution

Proper administration of ACULAR LS ensures optimal efficacy and minimizes potential side effects. Follow these guidelines:

• Dosage: Instill one drop into the affected eye(s) four times daily.
• Duration: Use for up to 4 days following corneal refractive surgery, as directed by your physician :contentReference[oaicite:5]{index=5}.
• Administration Tips:
  • Wash hands thoroughly before use.
  • Shake the bottle gently if required.
  • Tilting your head back, pull down the lower eyelid to create a small pocket.
  • Hold the dropper above the eye and instill one drop into the pocket.
  • Close your eye gently and press the inner corner for 1-2 minutes to prevent drainage.
• Precautions:
  • Do not touch the dropper tip to any surface, including the eye, to avoid contamination.
  • Remove contact lenses prior to application and wait at least 15 minutes before reinserting them :contentReference[oaicite:6]{index=6}.
  • If using other ophthalmic medications, wait at least 5 minutes between applications :contentReference[oaicite:7]{index=7}.

Always adhere to your healthcare provider's instructions regarding dosage and duration of use.

Mode of Action ACULAR LS 0.4% Ophthalmic Solution

Ketorolac tromethamine, the active component in ACULAR LS, functions by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes are pivotal in the biosynthesis of prostaglandins, which are mediators of inflammation and pain. By blocking COX activity, ketorolac reduces the production of prostaglandins, thereby alleviating inflammation and pain in ocular tissues :contentReference[oaicite:8]{index=8}.

This mechanism makes ACULAR LS effective in managing postoperative ocular discomfort and inflammation.

ACULAR LS 0.4% Ophthalmic Solution Interactions ACULAR LS 0.4% Ophthalmic Solution

While ACULAR LS is applied topically, it can still interact with other medications:

• Topical Corticosteroids: Concurrent use may increase the risk of delayed healing and corneal complications :contentReference[oaicite:9]{index=9}.
• Other NSAIDs: Combining with other NSAIDs may enhance the risk of adverse effects.
• Anticoagulants: Ketorolac may potentiate the effects of blood thinners, increasing bleeding risk :contentReference[oaicite:10]{index=10}.
• Contact Lens Solutions: Benzalkonium chloride, a preservative in ACULAR LS, can be absorbed by soft contact lenses. Avoid using the drops while wearing lenses :contentReference[oaicite:11]{index=11}.

Always inform your healthcare provider about all medications and supplements you are taking to avoid potential interactions.

Dosage of ACULAR LS 0.4% Ophthalmic Solution

The recommended dosage for ACULAR LS is:

• Adults and Children (≥3 years): One drop in the affected eye(s) four times daily for up to 4 days following corneal refractive surgery :contentReference[oaicite:12]{index=12}.

Adjustments to the dosage or duration should only be made under medical supervision.

Possible side effects of ACULAR LS 0.4% Ophthalmic Solution

While ACULAR LS is generally well-tolerated, some individuals may experience side effects:

• Common Side Effects:
  • Transient burning or stinging upon instillation.
  • Eye redness or irritation.
  • Headache.
• Less Common Side Effects:
  • Blurred vision.
  • Corneal edema or infiltrates.
  • Increased intraocular pressure.
• Rare but Serious Side Effects:
  • Corneal thinning, erosion, or ulceration.
  • Delayed wound healing.
  • Hypersensitivity reactions, including asthma exacerbation :contentReference[oaicite:13]{index=13}.

If you experience any severe or persistent side effects, discontinue use and consult your healthcare provider immediately.

ACULAR LS 0.4% Ophthalmic Solution Contraindications ACULAR LS 0.4% Ophthalmic Solution

ACULAR LS should not be used in the following situations:

• Known hypersensitivity to ketorolac, aspirin, or other NSAIDs.
• Allergy to any components of the formulation.
• Patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs :contentReference[oaicite:14]{index=14}.

Use with caution in individuals with bleeding disorders or those on anticoagulant therapy, as ketorolac may increase bleeding time.

Storage of ACULAR LS 0.4% Ophthalmic Solution

Proper storage ensures the medication's effectiveness and safety:

• Store at room temperature between 15°C to 25°C (59°F to 77°F).
• Keep the bottle tightly closed when not in use.
• Protect from light and moisture.
• Keep out of reach of children.
• Discard any unused solution 28 days after opening :contentReference[oaicite:15]{index=15}.

Do not use the solution if it becomes cloudy or changes color.