ACTONEL 30mg _ Tablets/Film-coated

What is ACTONEL 30mg _

ACTONEL 30mg is a prescription medication containing risedronate sodium, a bisphosphonate used to treat and prevent bone loss. It works by inhibiting osteoclast-mediated bone resorption, thereby maintaining or increasing bone mineral density. ACTONEL is indicated for:

• Paget’s disease of bone in men and women.
• Postmenopausal osteoporosis treatment and prevention.
• Osteoporosis in men to increase bone mass.
• Glucocorticoid-induced osteoporosis in patients receiving systemic corticosteroid therapy.

The 30mg dosage is specifically used for the treatment of Paget’s disease, typically administered once daily for 2 months. ACTONEL is supplied as film-coated tablets and should be taken under the guidance of a healthcare professional.

How to use ACTONEL 30mg _

Proper administration of ACTONEL is crucial to maximize its efficacy and minimize potential side effects:

• Timing: Take the tablet first thing in the morning, at least 30 minutes before consuming any food, beverages (other than plain water), or other medications.
• Administration: Swallow the tablet whole with a full glass (6–8 oz) of plain water. Do not chew, crush, or suck the tablet.
• Posture: Remain upright (sitting or standing) for at least 30 minutes after taking the tablet to reduce the risk of esophageal irritation.
• Missed Dose: If you miss a dose, do not take it later in the day. Skip the missed dose and resume your regular dosing schedule the next day. Do not take two doses on the same day.

Always follow your healthcare provider's instructions and read the patient information leaflet provided with the medication.

Mode of Action ACTONEL 30mg _

ACTONEL (risedronate sodium) is a bisphosphonate that:

• Inhibits osteoclast-mediated bone resorption: Risedronate binds to hydroxyapatite crystals in bone, reducing osteoclast activity and bone turnover.
• Maintains or increases bone mineral density: By decreasing bone resorption, it helps to preserve bone mass and strength.

This mechanism is particularly beneficial in conditions like Paget’s disease, where abnormal bone remodeling leads to weakened bones.

ACTONEL 30mg _ Interactions ACTONEL 30mg _

Several substances can interact with ACTONEL, affecting its absorption and efficacy:

• Calcium, magnesium, aluminum, or iron supplements: These can interfere with the absorption of risedronate. Take ACTONEL at least 30 minutes before these supplements.
• Antacids and mineral supplements: Should be taken at a different time of day to avoid interaction.
• NSAIDs (e.g., ibuprofen, naproxen): Concurrent use may increase the risk of gastrointestinal irritation.
• Other medications: Always inform your healthcare provider about all the medications you are taking to assess potential interactions.

To minimize interactions, take ACTONEL with plain water only and avoid other medications or supplements for at least 30 minutes afterward.

Dosage of ACTONEL 30mg _

The dosing regimen for ACTONEL varies based on the condition being treated:

• Paget’s disease: 30mg once daily for 2 months.
• Postmenopausal osteoporosis: 5mg once daily or 35mg once weekly.
• Osteoporosis in men: 35mg once weekly.
• Glucocorticoid-induced osteoporosis: 5mg once daily.

Always follow your healthcare provider's prescribed dosing schedule. Do not alter the dose without consulting your doctor.

Possible side effects of ACTONEL 30mg _

Like all medications, ACTONEL may cause side effects. Common side effects include:

• Abdominal pain
• Indigestion or heartburn
• Musculoskeletal pain (e.g., back, joint, or muscle pain)
• Headache

Serious but less common side effects may include:

• Esophageal ulcers or irritation
• Jaw bone problems (osteonecrosis)
• Unusual thigh bone fractures
• Severe musculoskeletal pain

Contact your healthcare provider if you experience any severe or persistent side effects.

ACTONEL 30mg _ Contraindications ACTONEL 30mg _

ACTONEL should not be used in individuals with:

• Esophageal abnormalities: Conditions that delay esophageal emptying, such as strictures or achalasia.
• Inability to stand or sit upright: For at least 30 minutes after taking the medication.
• Hypocalcemia: Low levels of calcium in the blood.
• Severe renal impairment: Creatinine clearance less than 30 mL/min.
• Known hypersensitivity: To risedronate sodium or any component of the product.

Discuss your medical history with your healthcare provider to ensure ACTONEL is safe for you.

Storage of ACTONEL 30mg _

To maintain the effectiveness of ACTONEL:

• Store at room temperature: Between 20°C to 25°C (68°F to 77°F).
• Keep in original packaging: Protects from moisture and light.
• Keep out of reach of children: To prevent accidental ingestion.
• Do not use expired medication: Check the expiration date on the packaging.

Proper storage ensures the medication remains safe and effective for use.