ACIC 400 Tablets

What is ACIC 400

ACIC 400 is an antiviral medication that contains Aciclovir 400mg as its active ingredient. It comes in tablet form and is typically packaged as 35 tablets (5s Blister x 7). This medicine is primarily used to manage and treat infections caused by the herpes virus, including:

• Herpes simplex virus (HSV) types 1 and 2 – responsible for cold sores and genital herpes
• Varicella-zoster virus – which causes chickenpox and shingles (herpes zoster)

ACIC 400 works by slowing the growth and spread of the herpes virus in the body. While it does not cure herpes infections, it significantly helps reduce the severity and duration of symptoms, and may also help prevent recurrences in some cases.

This medication may be used in both treatment and prevention scenarios. For people with frequent outbreaks, long-term suppressive therapy with ACIC 400 may be prescribed. Additionally, in immunocompromised patients, such as those undergoing chemotherapy or with HIV, ACIC 400 is used to prevent serious viral infections.

It is important to note that ACIC 400 should only be used under medical supervision, especially in patients with kidney issues or those taking other nephrotoxic drugs.

How to use ACIC 400

ACIC 400 Tablets should be taken exactly as prescribed by your healthcare provider. The dosage and duration of treatment depend on the type and severity of the viral infection, your medical history, and whether the medication is being used for treatment or prevention.

• Administration: Take the tablet by mouth with a full glass of water, usually 2 to 5 times a day depending on your condition.
• With or without food: ACIC 400 can be taken with or without food. If it causes stomach upset, take it with meals.
• Hydration: Drink plenty of fluids during treatment to reduce the risk of kidney issues.
• Adherence: Even if symptoms improve within a few days, complete the full course to ensure the infection is fully controlled.

In case of missed doses, take the missed tablet as soon as you remember, unless it is almost time for the next dose. Do not double the dose to make up for the missed one.

For maximum benefit, start taking ACIC 400 at the first sign of infection symptoms (such as tingling, itching, or burning). Delay in treatment may reduce its effectiveness.

Mode of Action ACIC 400

ACIC 400 (Aciclovir) is a nucleoside analogue antiviral drug that selectively targets viral DNA synthesis. It works in the following manner:

• Activation: Once inside an infected cell, Aciclovir is converted into aciclovir monophosphate by the virus-specific enzyme thymidine kinase.
• Further phosphorylation: Host cellular enzymes then convert the monophosphate into aciclovir triphosphate, the active form of the drug.
• Inhibition of viral DNA polymerase: Aciclovir triphosphate competes with the natural nucleotide deoxyguanosine triphosphate (dGTP) and incorporates into viral DNA.
• Chain termination: Once incorporated, it leads to premature termination of the DNA chain, halting viral replication.

This selective mechanism ensures that only virus-infected cells are targeted, minimizing damage to healthy cells. As a result, the spread of the herpes virus is controlled without significant toxicity to human cells.

The drug is especially effective against herpes simplex virus types 1 and 2, and varicella-zoster virus, making it highly useful in managing infections like genital herpes, cold sores, chickenpox, and shingles.

ACIC 400 Interactions ACIC 400

ACIC 400 may interact with other medications, altering its effectiveness or increasing the risk of side effects. Inform your doctor of all medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements.

• Probenecid: This medication can reduce the renal clearance of aciclovir, leading to increased levels in the blood and a higher risk of toxicity.
• Cimetidine: May also increase plasma levels of aciclovir due to reduced renal elimination.
• Mycophenolate mofetil: Combined use may increase plasma concentrations of both drugs, especially in renal impairment.
• Nephrotoxic drugs (e.g., aminoglycosides, cyclosporine, tacrolimus): Concomitant use increases the risk of kidney damage.

Always notify your healthcare provider if you are taking drugs that affect kidney function or if you have pre-existing renal conditions. Monitoring kidney function during long-term or high-dose therapy is advisable.

Dosage of ACIC 400

Dosage varies based on the condition being treated, patient’s age, kidney function, and whether the goal is treatment or prevention.

• For Herpes Simplex (initial episode): 400mg three times a day for 7–10 days
• For Herpes Simplex (recurrent episodes): 400mg three times a day for 5 days (start at first symptom)
• For Suppressive therapy: 400mg twice daily for up to 6–12 months
• For Herpes Zoster (shingles): 800mg five times a day for 7–10 days (note: higher than ACIC 400 dose)

Renal impairment: Dosage adjustments are necessary in patients with kidney disease. Always consult your doctor for personalized dosing.

Never self-medicate or adjust the dose without medical advice. Overdose may lead to renal toxicity and neurological symptoms like agitation, confusion, or even seizures.

Possible side effects of ACIC 400

Like all medications, ACIC 400 may cause side effects in some individuals. Most are mild and transient, but serious effects may occur in rare cases.

• Common side effects:
  • Nausea or vomiting
  • Diarrhea
  • Headache
  • Dizziness
  • Abdominal pain
• Less common side effects:
  • Fatigue
  • Skin rash or itching
  • Photosensitivity (sensitivity to sunlight)
• Rare but serious side effects:
  • Kidney dysfunction (especially in dehydrated or renal-impaired patients)
  • Hallucinations, confusion, or tremors
  • Seizures (in overdose or with renal impairment)
  • Allergic reactions (swelling, hives, anaphylaxis)

If you experience any unusual or severe symptoms, stop the medication and seek medical attention immediately.

ACIC 400 Contraindications ACIC 400

ACIC 400 is generally safe when used appropriately, but it is contraindicated in certain individuals. The following are conditions under which ACIC 400 should not be used:

• Hypersensitivity: Known allergy to aciclovir or any component of the formulation.
• Severe renal impairment: Without appropriate dose adjustment or monitoring, risk of toxicity increases.
• Neurological disorders: Use with caution in individuals with underlying neurological issues; may worsen symptoms in rare cases.

Special precautions should be taken in elderly patients, those who are dehydrated, or patients with compromised kidney function. Your doctor may perform kidney function tests before prescribing long-term or high-dose therapy.

Pregnant or breastfeeding women should use ACIC 400 only if clearly needed and prescribed by a physician, as limited data are available on its safety profile during pregnancy.

Storage of ACIC 400

Proper storage ensures the efficacy and safety of the medication throughout its shelf life.

• Temperature: Store ACIC 400 at room temperature between 15°C to 25°C (59°F to 77°F).
• Avoid moisture: Keep the tablets in their original blister packaging until use to protect from humidity.
• Away from light: Store in a dry place away from direct sunlight or high heat.
• Keep out of reach: Ensure the medication is stored securely out of the reach of children and pets.

Do not use the tablets after the expiry date printed on the packaging. If you notice any discoloration or unusual odor, consult your pharmacist before use.

Do not dispose of unused or expired medicine in household trash or flush it down the toilet. Follow your local pharmaceutical waste disposal guidelines.