ACIC 200 Tablets

What is ACIC 200

ACIC 200 is an oral antiviral medication that contains Aciclovir (Acyclovir) 200mg per tablet. It is used primarily for the treatment and prevention of infections caused by the herpes virus family. These include herpes simplex virus (HSV) types 1 and 2, which cause oral and genital herpes, as well as varicella-zoster virus (VZV), responsible for chickenpox and shingles (herpes zoster).

• Belongs to the class of drugs known as nucleoside analogues (antiviral agents).
• Specifically targets and inhibits viral replication inside infected cells.
• Commonly prescribed for:
  • Genital herpes (initial and recurrent episodes)
  • Cold sores (herpes labialis)
  • Shingles (herpes zoster)
  • Chickenpox (in high-risk or immunocompromised patients)
  • Prophylaxis in immunocompromised individuals

ACIC 200 is not a cure for herpes infections but helps to reduce symptom severity, frequency, and duration.

How to use ACIC 200

ACIC 200 tablets should be taken exactly as prescribed by your doctor. It is important to follow the recommended dosage and schedule to ensure optimal antiviral activity and to avoid resistance.

• Administration:
  • Take orally with or without food.
  • Swallow the tablet whole with a glass of water.
• Dosing frequency:
  • Usually taken 4 to 5 times a day, depending on the condition.
  • Maintain consistent intervals between doses (e.g., every 4 hours).
• Hydration: Adequate fluid intake is essential to prevent kidney side effects.
• Compliance:
  • Complete the full course even if symptoms resolve early.
  • Do not skip doses or stop abruptly without medical advice.

Set reminders if needed to maintain the regular dosing schedule.

Mode of Action ACIC 200

Aciclovir exerts its antiviral activity by selectively inhibiting the replication of herpes viruses. Its mechanism is highly specific to infected cells.

• Selective Activation: Once inside the body, aciclovir is converted by viral thymidine kinase (an enzyme produced by herpes-infected cells) into aciclovir monophosphate.
• Inhibition of DNA replication: This is further converted into aciclovir triphosphate, which acts as a faulty DNA building block. It:
  • Competes with deoxyguanosine triphosphate during DNA synthesis.
  • Incorporates into viral DNA and causes chain termination.
  • Effectively stops viral DNA polymerase activity.
• Host Cell Safety: It has minimal effect on human cells, making it highly selective and safe when used appropriately.

This mechanism controls the viral load, reduces outbreak severity, and shortens healing time.

ACIC 200 Interactions ACIC 200

While ACIC 200 is generally safe, certain drug interactions may influence its effectiveness or increase the risk of side effects.

• Probenecid: Slows renal clearance of aciclovir, increasing blood levels and duration of action.
• Other nephrotoxic drugs:
  • Such as cyclosporine, tacrolimus, aminoglycosides – increase the risk of kidney toxicity when used with aciclovir.
• Mycophenolate mofetil: Concomitant use may raise aciclovir levels, though usually without clinical significance.
• Theophylline: Aciclovir may increase serum levels; monitor closely in long-term use.
• Vaccines: Live virus vaccines may be less effective in patients taking antivirals like aciclovir.

Always inform your doctor or pharmacist about all medicines and supplements you're using.

Dosage of ACIC 200

Dosage varies depending on the infection being treated, patient age, renal function, and immune status.

• For Genital Herpes (Initial episode):
  • 200mg five times daily for 5–10 days
• For Recurrent Genital Herpes:
  • 200mg five times daily for 5 days or 800mg twice daily for 2 days
• For Shingles (Herpes Zoster):
  • 800mg five times daily for 7–10 days
• For Chickenpox:
  • 800mg four times daily for 5 days (in immunocompromised or adults)
• Renal Impairment: Dose adjustment is required depending on creatinine clearance.

Dosing should always be individualized by a physician.

Possible side effects of ACIC 200

ACIC 200 is generally well tolerated, but some individuals may experience side effects, especially with higher doses or prolonged use.

• Common side effects:
  • Nausea, vomiting
  • Diarrhea
  • Headache
  • Fatigue or dizziness
• Less common or serious side effects:
  • Skin rash or itching (hypersensitivity)
  • Abdominal pain
  • Confusion or hallucinations (especially in elderly or renal impairment)
  • Kidney function changes (in high doses or dehydration)
• Rare effects:
  • Hematologic abnormalities (anemia, leukopenia)
  • Seizures

Seek immediate medical help if signs of allergic reaction or severe side effects occur.

ACIC 200 Contraindications ACIC 200

ACIC 200 should not be used in certain cases where risks outweigh benefits.

• Known hypersensitivity: Patients allergic to aciclovir or any other component of the tablet.
• Severe dehydration: Increases the risk of renal toxicity.
• Caution in renal impairment: Dose adjustment required; monitor renal function closely.
• Pregnancy and breastfeeding: Use only if clearly needed. Consult a doctor.

Risk-benefit assessment should be done in patients with neurological disorders or electrolyte imbalances.

Storage of ACIC 200

Proper storage of ACIC 200 helps maintain its effectiveness and prevents degradation.

• Store in a cool, dry place at temperatures below 25°C (77°F).
• Protect from direct sunlight and moisture.
• Keep in the original blister packaging until use.
• Keep out of reach of children and pets.
• Do not use after the expiration date printed on the packaging.

Discard any damaged or discolored tablets and consult a pharmacist for proper disposal.