What is ACETYLCYSTEINE 200mg/ml (MARTINDALE)
ACETYLCYSTEINE 200mg/ml (MARTINDALE) is a sterile injectable solution of acetylcysteine, available in 10ml glass ampoules. It is primarily used as an antidote for paracetamol (acetaminophen) poisoning and also serves as a mucolytic agent in conditions involving thick or viscous mucus secretions, such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, and bronchitis.
- Generic Name: Acetylcysteine
- Form: Solution for Injection
- Concentration: 200 mg/mL
- Pack Size: 10ml Glass Ampoules × 10
Its clinical value lies in its ability to replenish glutathione levels, break down mucus, and counteract hepatotoxic effects in acetaminophen overdose.
How to use ACETYLCYSTEINE 200mg/ml (MARTINDALE)
The administration of ACETYLCYSTEINE injection should always be carried out under medical supervision.
- Paracetamol Overdose: Administered intravenously over a specific time schedule using a three-step infusion protocol (e.g., 150 mg/kg over 1 hour, 50 mg/kg over 4 hours, and 100 mg/kg over 16 hours).
- Mucolytic Indication: May be given intravenously or via inhalation when available in nebulized form, though this injectable solution is predominantly for IV use.
Always dilute the ampoule content before administration and use appropriate aseptic techniques. Dosing must be calculated based on body weight and clinical condition.
Mode of Action ACETYLCYSTEINE 200mg/ml (MARTINDALE)
Acetylcysteine acts via two primary mechanisms:
- As an antidote: It restores hepatic glutathione levels, allowing detoxification of NAPQI (a toxic metabolite of paracetamol), thereby preventing liver damage.
- As a mucolytic: The free sulfhydryl group in acetylcysteine breaks disulfide bonds in mucoproteins, reducing mucus viscosity and aiding clearance from the respiratory tract.
These actions make it effective in both life-threatening paracetamol overdose and chronic respiratory conditions involving retained secretions.
ACETYLCYSTEINE 200mg/ml (MARTINDALE) Interactions ACETYLCYSTEINE 200mg/ml (MARTINDALE)
Acetylcysteine has relatively few drug interactions, but caution is advised with the following:
- Activated charcoal: May adsorb acetylcysteine when administered orally, reducing its effectiveness (not relevant for IV form but worth noting).
- Nitroglycerin: Co-administration may enhance vasodilatory and hypotensive effects.
- Antibiotics: Mixing with some antibiotics (e.g., tetracyclines) in the same nebulizer can reduce effectiveness; less relevant for injection but important in alternate forms.
Always assess the patient's medication profile when administering acetylcysteine, especially in polypharmacy cases.
Dosage of ACETYLCYSTEINE 200mg/ml (MARTINDALE)
Dosage varies depending on the indication and patient's clinical condition:
- Paracetamol Overdose (Adult):
- Initial dose: 150 mg/kg IV over 1 hour
- Second dose: 50 mg/kg IV over 4 hours
- Third dose: 100 mg/kg IV over 16 hours
- Paracetamol Overdose (Pediatric): Similar to adult dosing, adjusted for body weight.
- Mucolytic use: Dosing is typically lower and depends on severity and response.
Dosages must be strictly calculated and infused over recommended time intervals to minimize adverse reactions.
Possible side effects of ACETYLCYSTEINE 200mg/ml (MARTINDALE)
While generally well tolerated, acetylcysteine may cause the following side effects:
- Common:
- Nausea and vomiting (especially with high doses)
- Flushing
- Urticaria (hives)
- Serious but Rare:
- Anaphylactoid reactions (rash, bronchospasm, hypotension)
- Chest tightness
- Severe hypotension
Adverse reactions can often be managed by slowing the infusion rate or temporarily discontinuing the drug. Emergency support should be available in the event of hypersensitivity reactions.
ACETYLCYSTEINE 200mg/ml (MARTINDALE) Contraindications ACETYLCYSTEINE 200mg/ml (MARTINDALE)
ACETYLCYSTEINE should not be used in the following cases:
- Known hypersensitivity: Allergy to acetylcysteine or any component of the formulation.
- Severe respiratory distress: For mucolytic purposes, acetylcysteine may worsen bronchospasm in susceptible individuals (more relevant in inhalation use).
- Advanced hepatic failure: Though used to protect the liver, caution is needed in severe hepatic impairment.
Relative caution is also required in patients with asthma or history of peptic ulcer disease.
Storage of ACETYLCYSTEINE 200mg/ml (MARTINDALE)
To maintain the stability and efficacy of this injectable solution, adhere to the following storage recommendations:
- Temperature: Store below 25°C (77°F). Do not freeze.
- Light protection: Keep ampoules in the original packaging to protect from light.
- Post-opening: Once an ampoule is opened, use immediately. Do not store opened ampoules for later use.
- Visual inspection: Do not use the solution if it is cloudy, discolored, or contains particulates.
Always keep medications out of the reach of children and follow local regulations for disposal of unused ampoules.
ACETYLCYSTEINE 200mg/ml (MARTINDALE) features an exceptional active ingredient renowned for its potent effects, comprising Acetylcysteine. This powerful formulation provides a superior solution for addressing diverse health concerns. With 200mg/ml concentration and an easily manageable Injection/Solution for, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ACETYLCYSTEINE 200mg/ml (MARTINDALE) .
Welcome to Dwaey, specifically on ACETYLCYSTEINE 200mg/ml (MARTINDALE) page.
This medicine contains an important and useful components, as it consists of Acetylcysteine.
ACETYLCYSTEINE 200mg/ml (MARTINDALE) is available in the market in concentration 200mg/ml and in the form of Injection/Solution for.
AURUM PHARMACEUTICALS LIMITED is the producer of ACETYLCYSTEINE 200mg/ml (MARTINDALE) and it is imported from UK,
The most popular alternatives of ACETYLCYSTEINE 200mg/ml (MARTINDALE) are listed downward .
-
Active Substance
-
Size
-
Indications
-
Type
-
Company
AURUM PHARMACEUTICALS LIMITED
Frequently Asked Questions
ACETYLCYSTEINE 200mg/ml (MARTINDALE) should be stored according to the instructions provided by AURUM PHARMACEUTICALS LIMITED.
In general, it is recommended to store ACETYLCYSTEINE 200mg/ml (MARTINDALE) in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ACETYLCYSTEINE 200mg/ml (MARTINDALE) may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ACETYLCYSTEINE 200mg/ml (MARTINDALE) for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ACETYLCYSTEINE 200mg/ml (MARTINDALE) . Some medications, including
ACETYLCYSTEINE 200mg/ml (MARTINDALE) , may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ACETYLCYSTEINE 200mg/ml (MARTINDALE) , take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ACETYLCYSTEINE 200mg/ml (MARTINDALE) without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ACETYLCYSTEINE 200mg/ml (MARTINDALE) if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ACETYLCYSTEINE 200mg/ml (MARTINDALE) during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 200mg/ml,
and the specific recommendations of AURUM PHARMACEUTICALS LIMITED.
The effects of ACETYLCYSTEINE 200mg/ml (MARTINDALE) on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 200mg/ml, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ACETYLCYSTEINE 200mg/ml (MARTINDALE) with or without food may vary depending on the medication
and the recommendations of AURUM PHARMACEUTICALS LIMITED. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ACETYLCYSTEINE 200mg/ml (MARTINDALE) in children or elderly individuals may depend on various factors, including
the specific medication, type Injection/Solution for, and the recommendations of AURUM PHARMACEUTICALS LIMITED. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ACETYLCYSTEINE 200mg/ml (MARTINDALE) in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
Related Products
0 Comments