ACETAMOL 1000mg Tablet

What is ACETAMOL 1000mg

ACETAMOL 1000mg is a high-strength formulation of Paracetamol (also known as Acetaminophen), an over-the-counter analgesic and antipyretic medication. It is commonly used to relieve mild to moderate pain and reduce fever. ACETAMOL is typically prescribed for conditions such as:

• Headache, including tension headaches and migraines
• Toothache and dental pain
• Musculoskeletal pain (e.g., backache, muscle aches)
• Osteoarthritis and joint pain
• Fever due to infections like the flu or common cold
• Post-operative pain

This 1000mg dosage is typically reserved for adults with more severe pain or high fever where lower doses have not been effective, and should only be used under the guidance of a healthcare provider due to the increased risk of liver toxicity at high doses.

How to use ACETAMOL 1000mg

To ensure safe and effective use of ACETAMOL 1000mg, follow these administration guidelines:

• Route: Oral. Swallow the tablet whole with water. Do not chew or crush.
• Timing: Can be taken with or without food. Taking with food may reduce stomach upset.
• Frequency: Typically 1 tablet (1000mg) every 6 to 8 hours, not exceeding 3 grams (3000mg) per day unless prescribed.
• Missed Dose: Take as soon as remembered unless it’s almost time for the next dose. Do not double dose.

Important notes:

• Do not use with other products containing paracetamol.
• Avoid alcohol as it increases the risk of liver damage.
• Consult a doctor if symptoms persist for more than 3 days.

Mode of Action ACETAMOL 1000mg

Paracetamol works through a dual mechanism:

• Central Analgesic Effect: It inhibits prostaglandin synthesis in the central nervous system (CNS), which are chemicals that cause pain and inflammation. This action results in effective pain relief.
• Antipyretic Effect: Paracetamol acts on the hypothalamic heat-regulating center to reduce fever by promoting heat dissipation through vasodilation and sweating.

Unlike non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol has minimal anti-inflammatory activity and does not irritate the stomach lining or cause gastric bleeding, making it suitable for patients with ulcers or NSAID sensitivity.

ACETAMOL 1000mg Interactions ACETAMOL 1000mg

Paracetamol has relatively few drug interactions, but caution is still advised:

• Alcohol: Increases risk of liver toxicity, especially with chronic consumption.
• Warfarin and other anticoagulants: Regular use of high doses may enhance anticoagulant effect and increase bleeding risk.
• Rifampin, Carbamazepine, and Phenytoin: These drugs induce liver enzymes that metabolize paracetamol, increasing the risk of hepatotoxicity.
• Isoniazid: May enhance liver toxicity when combined.
• Cholestyramine: May reduce absorption of paracetamol if taken together.

Always inform your healthcare provider about all medications and supplements you are taking.

Dosage of ACETAMOL 1000mg

The appropriate dosage depends on age, weight, and clinical condition:

• Adults: 1000mg every 6–8 hours as needed. Do not exceed 3000–4000mg per day.
• Elderly: Similar to adults, but monitor liver function more closely.
• Children: Not recommended for children under 12 unless prescribed in specific situations.

Overdose Warning: Excessive intake can cause life-threatening liver failure. Symptoms may include nausea, vomiting, abdominal pain, and jaundice. Seek immediate medical help in case of overdose.

Possible side effects of ACETAMOL 1000mg

Paracetamol is well tolerated at therapeutic doses, but side effects can occur, especially at high doses:

• Common: Generally none when used appropriately.
• Less Common:
  • Nausea or stomach discomfort
  • Skin rash or allergic reactions
• Rare but Serious:
  • Hepatotoxicity (especially with overdose)
  • Severe allergic reactions (anaphylaxis)
  • Thrombocytopenia, leukopenia (rare blood disorders)

If you experience yellowing of the skin or eyes, confusion, or unusual bleeding, seek medical help immediately.

ACETAMOL 1000mg Contraindications ACETAMOL 1000mg

This medicine is contraindicated in the following cases:

• Hypersensitivity to Paracetamol or any component of the tablet
• Severe liver impairment or active liver disease
• Chronic alcohol abuse
• G6PD deficiency: Use with caution due to rare risk of hemolysis

Paracetamol should be used with caution in patients with kidney disease, malnutrition, or those taking other hepatotoxic medications.

Storage of ACETAMOL 1000mg

Proper storage helps maintain the effectiveness of the medicine:

• Temperature: Store at room temperature between 15°C and 30°C (59°F–86°F).
• Humidity: Keep away from excessive moisture. Do not store in the bathroom.
• Light: Protect from direct sunlight.
• Container: Keep tablets in their original blister until use.
• Keep out of reach of children.

Do not use expired tablets. Safely discard unused medication as per local disposal regulations.