ACETAB 25mg Tablets

What is ACETAB 25mg

ACETAB 25mg is a film-coated tablet containing Captopril, an angiotensin-converting enzyme (ACE) inhibitor used primarily to manage high blood pressure (hypertension), heart failure, and certain types of kidney disease (especially diabetic nephropathy).

• Generic Name: Captopril
• Class: ACE Inhibitor
• Form: Tablets
• Strength: 25 mg
• Pack Size: 30 tablets (10s Blister x 3)

ACETAB 25mg lowers blood pressure by relaxing blood vessels, making it easier for the heart to pump blood and reducing strain on the cardiovascular system. It is often prescribed alone or with other antihypertensives and diuretics.

It is also effective in protecting kidney function in patients with diabetes and in preventing complications after a heart attack.

How to use ACETAB 25mg

Proper usage of ACETAB 25mg is critical to ensure therapeutic benefit and reduce the risk of side effects.

• Take the tablet by mouth with or without food. Food may delay the absorption but does not reduce the effectiveness.
• Use the medication at the same time every day for consistent blood levels.
• Swallow the tablet whole with water. Do not crush or chew.
• Always follow your doctor's instructions regarding dosing frequency and duration.
• Do not stop taking ACETAB suddenly, even if you feel well, unless instructed by your healthcare provider.
• Monitor your blood pressure regularly during treatment.

If you miss a dose, take it as soon as you remember. If it’s near the time of your next dose, skip the missed dose. Do not double up.

ACETAB is usually part of a long-term treatment plan, so consistent adherence is essential for optimal results.

Mode of Action ACETAB 25mg

Captopril, the active ingredient in ACETAB 25mg, works by inhibiting the angiotensin-converting enzyme (ACE).

• ACE plays a key role in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure and fluid balance.
• By inhibiting ACE, Captopril prevents the conversion of angiotensin I to angiotensin II—a potent vasoconstrictor.
• This results in dilation of blood vessels, reducing systemic vascular resistance and lowering blood pressure.
• It also decreases aldosterone secretion, promoting sodium and water excretion, which lowers blood volume and pressure.
• In patients with heart failure, this reduces the workload on the heart and improves cardiac output.

Captopril also helps protect kidneys from damage due to high blood sugar levels in diabetic patients.

ACETAB 25mg Interactions ACETAB 25mg

ACETAB (Captopril) may interact with other medications, which can affect its efficacy or increase the risk of side effects.

• Diuretics: May potentiate the hypotensive effect. Use with caution.
• Potassium supplements or potassium-sparing diuretics (e.g., Spironolactone): Risk of hyperkalemia.
• NSAIDs (e.g., Ibuprofen): May reduce antihypertensive effect and increase kidney toxicity risk.
• Other antihypertensives: Additive blood pressure-lowering effect; dose adjustments may be necessary.
• Insulin and oral antidiabetics: Risk of hypoglycemia due to increased insulin sensitivity.
• Lithium: Risk of lithium toxicity when used concurrently.
• Allopurinol: May increase the risk of leukopenia when taken with ACE inhibitors.

Always inform your doctor or pharmacist about all the medications, supplements, or herbal products you are taking before starting ACETAB.

Dosage of ACETAB 25mg

The dosage of ACETAB 25mg is individualized based on the condition being treated, the patient’s response, and kidney function.

• Hypertension: Initial dose is typically 12.5–25 mg two to three times daily. Maintenance dose: 25–50 mg two to three times daily.
• Congestive Heart Failure: Starting dose: 6.25–12.5 mg three times daily; may be increased based on response.
• Post-Myocardial Infarction: Initiate therapy as early as 3 days post-MI; start with 6.25 mg then increase to 25–50 mg twice daily.
• Diabetic Nephropathy: 25 mg three times daily is typically recommended.

Special Considerations:

• Adjust dose in patients with renal impairment.
• Monitor serum potassium and renal function regularly.

Possible side effects of ACETAB 25mg

Like all medications, ACETAB 25mg can cause side effects, although not everyone will experience them.

• Common:
  • Dry, persistent cough
  • Dizziness or lightheadedness
  • Fatigue
  • Headache
• Less Common but Serious:
  • Angioedema (swelling of the face, lips, or tongue)
  • Hypotension (especially after the first dose)
  • Hyperkalemia (high potassium levels)
  • Kidney dysfunction
  • Neutropenia or agranulocytosis (rare blood disorders)
• Gastrointestinal: Nausea, vomiting, diarrhea, taste disturbances

Report any unusual symptoms or allergic reactions to your healthcare provider immediately. Serious allergic reactions require emergency attention.

ACETAB 25mg Contraindications ACETAB 25mg

ACETAB 25mg is contraindicated in certain patient populations due to increased risks.

• History of angioedema related to previous ACE inhibitor therapy
• Pregnancy: Especially second and third trimesters—risk of fetal harm or death
• Bilateral renal artery stenosis or severe renal impairment
• Hypersensitivity to captopril or any component of the formulation
• Concomitant use with aliskiren in patients with diabetes or renal impairment

Use with caution in elderly patients, those with impaired renal function, or those with autoimmune disorders such as lupus.

Storage of ACETAB 25mg

To maintain the quality and efficacy of ACETAB 25mg, it should be stored properly.

• Store in a cool, dry place at a temperature below 30°C (86°F).
• Protect from moisture and direct sunlight.
• Keep the tablets in their original blister packaging until use to prevent degradation.
• Keep out of reach of children and pets.
• Do not use after the expiration date printed on the pack.

Dispose of unused or expired medicine according to local pharmacy or regulatory guidelines. Do not flush into toilets or pour into drains.