ACCUZIDE 20 Tablets/Film-coated

What is ACCUZIDE 20

ACCUZIDE 20 is a prescription medication combining two active ingredients: Quinapril hydrochloride, an angiotensin-converting enzyme (ACE) inhibitor, and Hydrochlorothiazide, a thiazide diuretic. This combination is primarily used to manage high blood pressure (hypertension) in adults.

• Quinapril HCl (20 mg): Helps relax blood vessels by inhibiting the formation of angiotensin II, a substance that narrows blood vessels.
• Hydrochlorothiazide (12.5 mg): Promotes the elimination of excess salt and water through urine, reducing blood volume and pressure.

By addressing hypertension through two different mechanisms, ACCUZIDE 20 effectively lowers blood pressure, reducing the risk of stroke, heart attack, and kidney problems.

How to use ACCUZIDE 20

Proper administration of ACCUZIDE 20 ensures optimal blood pressure control:

• Dosage: Take one tablet (20 mg Quinapril / 12.5 mg Hydrochlorothiazide) once daily, preferably in the morning.
• Administration: Swallow the tablet whole with a full glass of water. It can be taken with or without food.
• Consistency: Take the medication at the same time each day to maintain even blood levels.
• Missed Dose: If you miss a dose, take it as soon as you remember. If it's near the time of your next dose, skip the missed dose. Do not double up.
• Monitoring: Regularly check your blood pressure and report any significant changes to your healthcare provider.

Always follow your doctor's instructions and do not adjust your dose without consulting them.

Mode of Action ACCUZIDE 20

ACCUZIDE 20 combines two agents that lower blood pressure through complementary mechanisms:

• Quinapril HCl (ACE Inhibitor):
  • Blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor.
  • Results in vasodilation, reducing peripheral vascular resistance and lowering blood pressure.
  • Decreases aldosterone secretion, promoting sodium and water excretion.
• Hydrochlorothiazide (Thiazide Diuretic):
  • Inhibits sodium reabsorption in the distal tubules of the kidneys.
  • Increases excretion of sodium and water, reducing blood volume.
  • Helps prevent fluid retention and lowers blood pressure.

The combination targets both vascular resistance and blood volume, providing a synergistic effect in controlling hypertension.

ACCUZIDE 20 Interactions ACCUZIDE 20

ACCUZIDE 20 may interact with various medications, affecting its efficacy or increasing the risk of adverse effects:

• Potassium Supplements and Potassium-Sparing Diuretics: May increase the risk of hyperkalemia (high potassium levels).
• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Can reduce the antihypertensive effect and increase the risk of kidney dysfunction.
• Lithium: Concurrent use may increase lithium levels and risk of toxicity.
• Other Antihypertensives: May enhance blood pressure-lowering effects, leading to hypotension.
• Diabetes Medications: Hydrochlorothiazide may affect blood glucose control.
• Alcohol: Can potentiate the blood pressure-lowering effect, increasing the risk of dizziness or fainting.

Always inform your healthcare provider about all medications and supplements you are taking to avoid potential interactions.

Dosage of ACCUZIDE 20

The dosage of ACCUZIDE 20 should be individualized based on patient needs:

• Initial Therapy: Not recommended as the first-line treatment. Patients should be stabilized on individual components before switching to the combination.
• Maintenance Dose: One tablet (20 mg Quinapril / 12.5 mg Hydrochlorothiazide) once daily.
• Adjustment: Dosage may be adjusted based on blood pressure response, with careful monitoring.
• Renal Impairment: Use with caution. Not recommended in patients with severe renal dysfunction (creatinine clearance ≤30 mL/min).
• Hepatic Impairment: Use cautiously; monitor for adverse effects.

Regular monitoring of blood pressure, electrolytes, and kidney function is essential during treatment.

Possible side effects of ACCUZIDE 20

While ACCUZIDE 20 is generally well-tolerated, some patients may experience side effects:

• Common:
  • Dizziness or lightheadedness
  • Headache
  • Fatigue
  • Dry cough
• Less Common:
  • Nausea or vomiting
  • Muscle cramps
  • Increased urination
  • Rash
• Serious (Seek immediate medical attention):
  • Swelling of the face, lips, tongue, or throat (angioedema)
  • Severe dizziness or fainting
  • Signs of kidney problems (e.g., change in urine output)
  • Electrolyte imbalances (e.g., irregular heartbeat, muscle weakness)

Report any unusual or persistent symptoms to your healthcare provider promptly.

ACCUZIDE 20 Contraindications ACCUZIDE 20

ACCUZIDE 20 should not be used in the following situations:

• Hypersensitivity: To quinapril, hydrochlorothiazide, or any component of the formulation.
• History of Angioedema: Associated with previous ACE inhibitor therapy.
• Anuria: Severe kidney dysfunction with no urine production.
• Concomitant Use with Aliskiren: In patients with diabetes or renal impairment.
• Pregnancy: Especially during the second and third trimesters due to risk of fetal harm.
• Severe Hepatic Impairment: Use with caution; contraindicated in severe cases.

Always consult your healthcare provider before starting or stopping any medication.

Storage of ACCUZIDE 20

Proper storage of ACCUZIDE 20 ensures its effectiveness and safety:

• Temperature: Store at room temperature between 20°C to 25°C (68°F to 77°F).
• Container: Keep in the original packaging, tightly closed to protect from moisture and light.
• Out of Reach: Store away from children and pets.
• Do Not Use: Beyond the expiration date printed on the packaging.
• Disposal: Dispose of unused or expired medication according to local regulations or consult your pharmacist.

Do not store in the bathroom or areas with high humidity.