ACC 200 Solution (Oral)/Powder for

What is ACC 200

ACC 200 is a mucolytic medication that contains the active ingredient Acetylcysteine. It is presented as a powder in sachets, each containing 3 grams of acetylcysteine, designed to be dissolved in water and taken orally. This formulation is used for the treatment of respiratory conditions characterized by thick mucus or excessive phlegm.

• Primary Use: ACC 200 is commonly prescribed to loosen mucus in conditions such as chronic bronchitis, emphysema, cystic fibrosis, and pneumonia.
• Respiratory Benefits: It breaks down mucus, making it easier to cough up, thereby improving airflow and easing breathing.
• Antioxidant Properties: Acetylcysteine also acts as a powerful antioxidant by replenishing levels of glutathione, a critical substance that helps the body neutralize harmful free radicals.
• Secondary Uses: ACC 200 may also be used in the management of acetaminophen (paracetamol) overdose as an antidote due to its ability to protect the liver from toxic damage.
• Formulation: Each sachet of ACC 200 contains a water-soluble powder that is flavored to improve palatability, making it suitable for both adults and adolescents.

ACC 200 provides a dual mechanism of action by not only thinning mucus but also offering antioxidant defense, making it a valuable choice for respiratory tract support.

How to use ACC 200

Proper administration of ACC 200 ensures optimal therapeutic outcomes. It is important to follow the healthcare provider’s instructions and the product leaflet carefully.

• Preparation: Dissolve the contents of one 3g sachet completely in half a glass (approx. 100ml) of hot or cold water. Stir until fully dissolved before drinking.
• Timing: Take the solution immediately after preparation. Do not store the dissolved solution for later use.
• Frequency: Usually taken 1–3 times daily depending on the condition and the doctor's recommendation.
• With or Without Food: ACC 200 can be taken with or without meals. However, taking it after meals may help minimize gastrointestinal side effects like nausea.
• Hydration: Ensure adequate fluid intake throughout the day to assist the mucolytic effect of the medicine.
• Missed Dose: If you forget to take a dose, take it as soon as you remember. Do not double the dose to make up for a missed one.

Do not exceed the recommended dosage without medical advice. Prolonged or unsupervised use should be avoided, especially in chronic respiratory conditions.

Mode of Action ACC 200

ACC 200 (Acetylcysteine) works through several mechanisms to relieve respiratory symptoms and protect the body from oxidative stress.

• Mucolytic Action: Acetylcysteine breaks the disulfide bonds in mucoproteins, which reduces the viscosity of mucus in the airways. This liquefied mucus is easier to expel through coughing or natural clearance.
• Improved Airway Clearance: By thinning thick, tenacious phlegm, it helps restore normal respiratory function and improves oxygen exchange.
• Antioxidant Effect: Acetylcysteine is a precursor of glutathione, one of the most important antioxidants in the body. It helps replenish depleted glutathione levels, thereby reducing oxidative damage in tissues.
• Cellular Protection: By supporting antioxidant defenses, ACC 200 may help protect lung cells from damage induced by infections, smoking, pollution, and chronic inflammation.
• Anti-inflammatory Properties: Some studies also suggest that acetylcysteine may reduce the recruitment of inflammatory cells in the lungs, indirectly contributing to symptom improvement in chronic conditions.

Thanks to these combined effects, ACC 200 not only addresses mucus accumulation but also provides systemic benefits in conditions involving oxidative stress.

ACC 200 Interactions ACC 200

ACC 200 is generally well tolerated but may interact with certain medications, which can affect its efficacy or increase the risk of adverse effects.

• Antibiotics: Acetylcysteine may reduce the effectiveness of certain antibiotics like tetracyclines and aminoglycosides when taken together. It is recommended to separate doses by at least 2 hours.
• Activated Charcoal: May reduce the absorption of acetylcysteine. Concurrent use should be avoided unless advised by a healthcare provider.
• Nitroglycerin: Concomitant use may enhance the vasodilatory effect of nitroglycerin and lead to increased risk of hypotension and headache. Close monitoring is advised if both are prescribed together.
• Cough Suppressants: Should be avoided with ACC 200 unless prescribed by a doctor. While ACC 200 works to clear mucus, antitussives may inhibit the cough reflex, potentially causing mucus retention.
• Bronchodilators: May be used concurrently in respiratory conditions for enhanced mucolytic and bronchodilatory effects, but dosage and timing should be managed by a healthcare professional.

Always inform your healthcare provider about all medications, supplements, or herbal remedies you are taking before starting ACC 200. This will help prevent adverse interactions and ensure optimal therapeutic outcomes.

Dosage of ACC 200

The appropriate dosage of ACC 200 depends on the patient's age, medical condition, and the severity of mucus build-up. Always follow the prescribing physician's advice.

• Adults and Adolescents (over 14 years): The usual dose is 1 sachet (3g) once or twice daily.
• Children (6–14 years): Generally, 600mg per day, which may require a lower-dose formulation (e.g., ACC 100 or ACC Junior), not ACC 200.
• Children under 6 years: ACC 200 is not recommended. Pediatric formulations are preferred due to the high dosage in each sachet.
• Chronic Conditions: For chronic bronchitis or cystic fibrosis, prolonged treatment may be prescribed under strict medical supervision, with ongoing evaluation of lung function and symptom control.
• Acetaminophen Overdose: High-dose acetylcysteine is used in hospital settings for paracetamol toxicity but is not administered as ACC 200. Specialized IV or oral formulations are required.
• Administration Schedule: ACC 200 should be taken at consistent times daily to maintain steady therapeutic levels. Adherence to dosing improves outcomes and prevents mucus accumulation.

Do not exceed the recommended dose. If symptoms persist beyond 5–7 days of treatment, consult a healthcare professional for further evaluation.

Possible side effects of ACC 200

ACC 200 is considered safe and well tolerated in most individuals. However, like all medications, it may cause side effects, ranging from mild to rarely severe.

• Common Side Effects:
  • Gastrointestinal disturbances such as nausea, vomiting, and diarrhea
  • Stomach pain or bloating
  • Unpleasant taste or aftertaste
  • Headache
• Less Common Side Effects:
  • Rash or skin irritation
  • Fever or chills
  • Tinnitus (ringing in the ears)
• Rare but Serious Reactions:
  • Anaphylactic reactions (swelling, difficulty breathing)
  • Bronchospasm, especially in patients with asthma or COPD
  • Severe skin reactions like Stevens-Johnson Syndrome (very rare)

If you experience signs of a serious allergic reaction or worsening respiratory symptoms, discontinue use and seek immediate medical attention. Most mild side effects are self-limiting and resolve without treatment.

ACC 200 Contraindications ACC 200

There are specific situations where ACC 200 should not be used, as the risks may outweigh the potential benefits.

• Hypersensitivity: Known allergy to acetylcysteine or any component of the formulation (e.g., sweeteners, flavors).
• Active Peptic Ulcer: ACC 200 may irritate the gastrointestinal lining and worsen ulcerative conditions.
• Asthma: Use with caution. In rare cases, ACC 200 can cause bronchospasm, especially in patients with uncontrolled asthma.
• Children under 6: The 3g dose is not appropriate for young children due to the high content of acetylcysteine.
• Phenylketonuria: Some formulations may contain aspartame, which is contraindicated in patients with this condition.
• Pregnancy and Lactation: Use only if clearly needed and prescribed by a healthcare provider. There is limited human data regarding safety in pregnancy.

Always perform a full medical assessment before initiating treatment with ACC 200, especially in patients with chronic respiratory diseases or gastrointestinal disorders.

Storage of ACC 200

Proper storage of ACC 200 helps preserve its effectiveness and prevent degradation of the active ingredient.

• Temperature: Store at room temperature, ideally between 15–25°C (59–77°F).
• Humidity: Protect from moisture. Keep sachets sealed in their original packaging until use.
• Light: Store away from direct sunlight or sources of heat that may degrade the contents.
• Child Safety: Keep out of reach of children to avoid accidental ingestion.
• After Preparation: Once the powder is dissolved, consume the solution immediately. Do not store the prepared solution for later use.
• Expiration Date: Always check the expiry date on the packaging before use. Do not use expired medication.

Improper storage can reduce the efficacy of acetylcysteine and may compromise its therapeutic benefit. If a sachet is damaged or discolored, discard it and consult a pharmacist for a replacement.