DIABACT UBT 50MG Tablets

What is DIABACT UBT 50MG

DIABACT UBT 50MG is a diagnostic medicine that contains Urea labeled with Carbon-13 isotope (C¹³ Urea). It is primarily used in the Urea Breath Test (UBT) to detect the presence of Helicobacter pylori (H. pylori) infection in the stomach. This infection is a common cause of peptic ulcers and gastritis and is also associated with gastric malignancies.

• Form: Oral tablet containing 50 mg of C¹³-labeled urea.
• Purpose: Diagnostic only—used to confirm the presence or absence of active H. pylori infection.
• Mechanism: Based on the urease activity of H. pylori, which breaks down urea into CO₂ that can be measured in breath samples.
• Non-invasive: This test offers a reliable, non-invasive alternative to endoscopy or biopsy.
• Highly accurate: High sensitivity and specificity when administered under recommended guidelines.

DIABACT UBT is not used for treatment—it is strictly for diagnostic purposes in adults and children who can cooperate with breath sample collection procedures.

How to use DIABACT UBT 50MG

DIABACT UBT 50MG is taken orally as part of a structured diagnostic test protocol, typically in a medical or diagnostic setting. Proper preparation and adherence to guidelines are essential for accurate results.

• Fasting Required: Patients must fast for at least 6 hours prior to the test.
• Baseline Sample: A baseline breath sample is collected before taking the tablet.
• Administration: The 50 mg tablet is swallowed whole with a citric acid solution or test drink to slow gastric emptying.
• Post-Ingestion: After 30 minutes, a second breath sample is collected for analysis.
• Avoid Interfering Drugs: Discontinue proton pump inhibitors, antibiotics, and bismuth-containing compounds 2–4 weeks before the test.
• Supervised Use: Always taken under medical supervision to ensure compliance and proper sample collection.

Following the procedure, the breath samples are analyzed using isotope ratio mass spectrometry or infrared spectroscopy to detect elevated levels of C¹³-labeled carbon dioxide.

Mode of Action DIABACT UBT 50MG

The active ingredient in DIABACT UBT 50MG—C¹³-labeled urea—acts as a substrate for the urease enzyme produced by H. pylori in the stomach.

• When C¹³ urea reaches the stomach, it comes into contact with H. pylori if the bacteria are present.
• H. pylori secretes urease, which hydrolyzes the urea into ammonia (NH₃) and C¹³-labeled carbon dioxide (C¹³O₂).
• The C¹³O₂ is absorbed into the bloodstream and transported to the lungs.
• It is then exhaled and measured via breath sampling.

If significant levels of C¹³O₂ are detected in the exhaled breath, it indicates the presence of active H. pylori infection. If not, the test is considered negative. The method is precise, rapid, and reflects ongoing infection, unlike serological tests which may remain positive long after treatment.

DIABACT UBT 50MG Interactions DIABACT UBT 50MG

DIABACT UBT 50MG, being a diagnostic agent, does not directly interact with the body’s metabolism or biochemical pathways. However, interactions with medications or substances that affect H. pylori presence or urease activity can lead to inaccurate test results.

• Proton Pump Inhibitors (PPIs): Medications like omeprazole, lansoprazole, or pantoprazole should be stopped at least 2 weeks prior to the test.
• Antibiotics: Should be discontinued at least 4 weeks before the test to avoid false-negative results.
• Bismuth Compounds: Products like Pepto-Bismol should also be avoided for at least 4 weeks.
• Antacids: While they have minimal effect, frequent use may slightly reduce test sensitivity.
• Food & Drink: Avoid food, alcohol, and caffeine before the test as these can alter gastric pH or motility.

Inform your healthcare provider of all medications and supplements you're taking before the test to avoid compromised results.

Dosage of DIABACT UBT 50MG

The dosage of DIABACT UBT 50MG is standardized and depends on the age and body weight of the patient.

• Adults: One 50 mg tablet of C¹³ Urea taken orally with a citric acid-based test drink.
• Children (age-specific): Typically, a single 50 mg tablet is sufficient for children over 3 years who can follow instructions. Dosage should be adjusted according to the child’s weight and under strict medical supervision.
• Timing: Breath sample is collected at 30 minutes post-administration.
• Repeat Testing: Used again 4–6 weeks after eradication therapy to confirm treatment success.

The test should only be conducted under trained healthcare supervision, and strict adherence to fasting and medication restriction is crucial to prevent diagnostic inaccuracies.

Possible side effects of DIABACT UBT 50MG

DIABACT UBT 50MG is generally well tolerated since it is not absorbed systemically in a pharmacologically active manner. However, minor and rare adverse reactions may occur.

• Gastrointestinal Discomfort: Mild bloating, nausea, or flatulence after ingestion of the test drink.
• Allergic Reactions: Rare; hypersensitivity to excipients may cause rash, itching, or swelling.
• Respiratory Reactions: Some may experience coughing or slight discomfort during breath sample collection.
• Taste Disturbance: Some patients report an unpleasant taste due to the citric acid test drink.

These side effects are typically transient and resolve without intervention. If any severe reactions occur, medical attention should be sought promptly.

DIABACT UBT 50MG Contraindications DIABACT UBT 50MG

Though generally safe, DIABACT UBT 50MG is contraindicated in specific conditions due to safety concerns or test reliability issues.

• Hypersensitivity: Known allergy to urea or any excipients in the formulation.
• Young children: Children under 3 years or those who cannot cooperate with breath sampling.
• Severe Respiratory Conditions: May interfere with breath sample collection and accuracy.
• Recent H. pylori Therapy: Testing too soon after eradication therapy may produce false results.

Testing should be deferred in patients who have taken antibiotics or PPIs recently or who are unable to follow the test protocol.

Storage of DIABACT UBT 50MG

Proper storage of DIABACT UBT 50MG is essential to maintain the stability and accuracy of the diagnostic compound.

• Storage Temperature: Store below 25°C in a dry place away from moisture and direct sunlight.
• Original Packaging: Keep tablets in their original blister packs to avoid contamination.
• Protect from Humidity: Ensure the packaging remains sealed until use to preserve test accuracy.
• Keep Out of Reach of Children: This is a diagnostic tool, not a medicinal product for daily use.
• Shelf Life: Follow the manufacturer’s expiration date printed on the pack.

Do not use the product if the packaging is damaged or if the tablet shows signs of discoloration or deterioration.