What is DEXMEDETOMIDINE EVER PHARMA 100mcg/ml
DEXMEDETOMIDINE EVER PHARMA 100 mcg/ml is a sterile, preservative-free concentrate for solution for infusion, manufactured by EVER Pharma. The active ingredient, dexmedetomidine, is a potent, highly selective alpha-2 adrenergic receptor agonist used primarily for sedation of adult patients in intensive care units (ICUs) and for procedural sedation. It is supplied in 2 ml glass vials, with each vial containing 200 mcg of dexmedetomidine (100 mcg/ml concentration).
- Form: Concentrate for solution for infusion
- Strength: 100 mcg/ml (200 mcg per 2 ml vial)
- Packaging: 5 glass vials x 2 ml
- Generic Name: Dexmedetomidine
- Therapeutic Class: Sedative and anxiolytic agent
This formulation is used in various clinical settings where light to moderate sedation is required without the risk of respiratory depression. Its ability to allow easy patient arousability makes it a preferred choice in conscious sedation protocols and post-operative care.
How to use DEXMEDETOMIDINE EVER PHARMA 100mcg/ml
DEXMEDETOMIDINE EVER PHARMA must be diluted before administration and given as an intravenous infusion. It should only be used in hospital settings by healthcare professionals trained in sedation and cardiovascular monitoring.
- Dilution: Dilute the concentrate in 0.9% sodium chloride to achieve a concentration of 4 mcg/ml
- Administration Route: Intravenous infusion only; not for bolus or intramuscular use
- Infusion Rate: Titrate to desired sedation level; infusion pump is recommended for accuracy
- Monitoring: Continuous monitoring of ECG, oxygen saturation, and blood pressure is mandatory during use
The diluted solution should be used within 24 hours of preparation. Avoid rapid infusion or bolus injection as it may cause significant hemodynamic effects such as bradycardia or hypertension. Titrate the dose gradually, especially in patients with comorbidities or elderly individuals.
Mode of Action DEXMEDETOMIDINE EVER PHARMA 100mcg/ml
Dexmedetomidine works by selectively stimulating alpha-2 adrenergic receptors in the brain and spinal cord, particularly in the locus coeruleus. This results in inhibition of norepinephrine release, producing a sedative, anxiolytic, and analgesic effect.
- Central Alpha-2 Agonism: Suppresses sympathetic nervous system activity
- Sedation: Induces a calm, cooperative sedation without respiratory depression
- Analgesia: Provides moderate pain relief through inhibition of pain signal transmission
- Hemodynamic Effects: Lowers blood pressure and heart rate through reduced catecholamine release
This mechanism of action offers a unique advantage over other sedatives such as benzodiazepines, as patients can remain rousable and interactive while still achieving effective sedation. It also helps in reducing opioid requirements in certain settings.
DEXMEDETOMIDINE EVER PHARMA 100mcg/ml Interactions DEXMEDETOMIDINE EVER PHARMA 100mcg/ml
DEXMEDETOMIDINE may interact with a number of other drugs, particularly those affecting the cardiovascular and central nervous systems. Co-administration should be done cautiously with adequate patient monitoring.
- Opioids: Synergistic effects on sedation and analgesia; may increase risk of bradycardia and hypotension
- Anesthetics: Potentiates sedative and hemodynamic effects of volatile and IV anesthetics
- Beta-blockers & Calcium Channel Blockers: May exacerbate hypotension and bradycardia
- Diuretics & Antihypertensives: Enhanced risk of profound hypotension
- Other Sedatives: May cause excessive CNS depression
Dexmedetomidine is metabolized primarily by the liver via glucuronidation and minor cytochrome P450 pathways. Though significant CYP-mediated drug interactions are uncommon, close clinical observation is advised when combined with other sedative or cardiovascular agents.
Dosage of DEXMEDETOMIDINE EVER PHARMA 100mcg/ml
Dosing should be individualized and based on patient weight, sedation goals, and overall clinical status. It is important to dilute the concentrate before administration to achieve the appropriate infusion concentration (typically 4 mcg/ml).
- ICU Sedation: Optional loading dose of 1 mcg/kg over 10 minutes, followed by maintenance infusion of 0.2–0.7 mcg/kg/hr
- Procedural Sedation: Loading dose of 1 mcg/kg over 10 minutes, followed by 0.6–1 mcg/kg/hr during the procedure
- Hepatic Impairment: Reduce dose due to prolonged half-life
- Elderly: Start at the lower end of dosing range
Discontinue infusion slowly, especially after prolonged use, to minimize risks of rebound hypertension or withdrawal symptoms. Always titrate to the desired level of sedation with careful hemodynamic monitoring.
Possible side effects of DEXMEDETOMIDINE EVER PHARMA 100mcg/ml
While generally safe under professional supervision, DEXMEDETOMIDINE can produce adverse effects, primarily cardiovascular and neurological in nature. These side effects are dose-dependent and often reversible upon dose reduction or cessation.
- Very Common: Hypotension, bradycardia, dry mouth
- Common: Nausea, hypertension (especially during loading), dizziness
- Serious: Sinus arrest, AV block, cardiac arrest (rare)
- Withdrawal Symptoms: Tachycardia, agitation, headache, rebound hypertension
Patients with underlying cardiovascular disease, volume depletion, or those receiving concomitant antihypertensives are at increased risk. Close monitoring during infusion and for several hours post-infusion is recommended, especially in high-risk patients.
DEXMEDETOMIDINE EVER PHARMA 100mcg/ml Contraindications DEXMEDETOMIDINE EVER PHARMA 100mcg/ml
DEXMEDETOMIDINE is contraindicated in certain patient populations where its pharmacological effects may exacerbate pre-existing conditions.
- Known Hypersensitivity: To dexmedetomidine or formulation components
- Advanced Heart Block: Second- or third-degree AV block without pacemaker support
- Severe Bradycardia: Clinically significant bradycardia not responsive to treatment
- Acute Uncontrolled Hypotension: May further reduce blood pressure
- Severe Hepatic Impairment: Slower metabolism increases risk of accumulation and side effects
Use caution in patients with neurological conditions or those on other sedatives or negative chronotropic agents. Benefit-risk assessment should be conducted in borderline cases, and alternative sedative agents considered if necessary.
Storage of DEXMEDETOMIDINE EVER PHARMA 100mcg/ml
Proper storage conditions are essential to maintain the sterility and efficacy of DEXMEDETOMIDINE EVER PHARMA concentrate.
- Storage Temperature: Store at 15°C to 25°C (59°F to 77°F)
- Light Protection: Keep in the original carton to protect from light
- Freezing: Do not freeze
- After Dilution: Use within 24 hours; store between 2°C to 8°C if not used immediately
- Vial Integrity: Do not use if solution is discolored or contains particulate matter
Keep out of reach of unauthorized personnel. Follow institutional guidelines for proper disposal of unused or expired product. Do not reuse single-use vials, and ensure aseptic technique during dilution and administration.
DEXMEDETOMIDINE EVER PHARMA 100mcg/ml features an exceptional active ingredient renowned for its potent effects, comprising Dexmedetomidine. This powerful formulation provides a superior solution for addressing diverse health concerns. With 100 micrograms/ml concentration and an easily manageable Concentrate for solution for infusion, it remains a preferred option for countless individuals seeking effective treatment.
Introduction to DEXMEDETOMIDINE EVER PHARMA 100mcg/ml
DEXMEDETOMIDINE EVER PHARMA 100mcg/ml is a medication used for sedation in adult intensive care unit (ICU) patients. The active ingredient in DEXMEDETOMIDINE EVER PHARMA 100mcg/ml is dexmedetomidine, a selective alpha-2 adrenergic receptor agonist that produces sedative and analgesic effects.
How does DEXMEDETOMIDINE EVER PHARMA 100mcg/ml work?
DEXMEDETOMIDINE EVER PHARMA 100mcg/ml works by selectively activating alpha-2 adrenergic receptors in the brain, resulting in sedation and analgesia. It has minimal respiratory depression and does not cause significant changes in heart rate or blood pressure, making it a preferred choice for sedation in ICU patients.
Dosage and Administration of DEXMEDETOMIDINE EVER PHARMA 100mcg/ml
DEXMEDETOMIDINE EVER PHARMA 100mcg/ml is administered through an IV infusion and should only be administered by a healthcare professional trained in its use. The recommended initial dose is 0.2-0.7 mcg/kg/hour, and the dose can be titrated up or down to achieve the desired level of sedation. It is important to monitor the patient s vital signs and level of consciousness while on DEXMEDETOMIDINE EVER PHARMA 100mcg/ml.
Precautions and Side Effects of DEXMEDETOMIDINE EVER PHARMA 100mcg/ml
Like any medication, DEXMEDETOMIDINE EVER PHARMA 100mcg/ml may cause side effects. Common side effects include hypotension, bradycardia, and dry mouth. However, these side effects can be managed with appropriate monitoring and medication adjustments.
DEXMEDETOMIDINE EVER PHARMA 100mcg/ml should be used with caution in patients with pre-existing cardiovascular disease or those who are hemodynamically unstable. It should also be used with caution in patients with severe hepatic impairment, as the drug is metabolized in the liver.
Introduction
All you need to know about DEXMEDETOMIDINE EVER PHARMA 100mcg/ml .
Welcome to Dwaey, specifically on DEXMEDETOMIDINE EVER PHARMA 100mcg/ml page.
This medicine contains an important and useful components, as it consists of Dexmedetomidine.
DEXMEDETOMIDINE EVER PHARMA 100mcg/ml is available in the market in concentration 100 micrograms/ml and in the form of Concentrate for solution for infusion.
EVER VALINJECT GMBH is the producer of DEXMEDETOMIDINE EVER PHARMA 100mcg/ml and it is imported from AUSTRIA,
The most popular alternatives of DEXMEDETOMIDINE EVER PHARMA 100mcg/ml are listed downward .
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Frequently Asked Questions
DEXMEDETOMIDINE EVER PHARMA 100mcg/ml should be stored according to the instructions provided by EVER VALINJECT GMBH.
In general, it is recommended to store DEXMEDETOMIDINE EVER PHARMA 100mcg/ml in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with DEXMEDETOMIDINE EVER PHARMA 100mcg/ml may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking DEXMEDETOMIDINE EVER PHARMA 100mcg/ml for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking DEXMEDETOMIDINE EVER PHARMA 100mcg/ml. Some medications, including
DEXMEDETOMIDINE EVER PHARMA 100mcg/ml, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of DEXMEDETOMIDINE EVER PHARMA 100mcg/ml, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking DEXMEDETOMIDINE EVER PHARMA 100mcg/ml without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking DEXMEDETOMIDINE EVER PHARMA 100mcg/ml if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of DEXMEDETOMIDINE EVER PHARMA 100mcg/ml during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 100 micrograms/ml,
and the specific recommendations of EVER VALINJECT GMBH.
The effects of DEXMEDETOMIDINE EVER PHARMA 100mcg/ml on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 100 micrograms/ml, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking DEXMEDETOMIDINE EVER PHARMA 100mcg/ml with or without food may vary depending on the medication
and the recommendations of EVER VALINJECT GMBH. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of DEXMEDETOMIDINE EVER PHARMA 100mcg/ml in children or elderly individuals may depend on various factors, including
the specific medication, type Concentrate for solution for infusion, and the recommendations of EVER VALINJECT GMBH. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of DEXMEDETOMIDINE EVER PHARMA 100mcg/ml in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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