About dexmedetomidine

Anesthetic and hypnotic drug, a stimulator of the alpha-A2 adrenergic receptors located in the brain that leads to G activity and inhibition of norepinephrine release.

When given in high doses or intravenously, it stimulates alpha-B2 receptors located in the peripheral nerves, causing the ligament to contract.

Dexmedetomidine side effects

Low or high blood pressure.

Slow or fast heartbeat.

Irritability, constipation, nausea.

High or low blood sugar.

Low level of magnesium in the blood.

Decreased level of calcium in the blood.

Edema, oliguria, fever.

Uses of dexmedetomidine

Procedural anesthesia before and during endoscopic fibrous intubation (insertion of a tube).

An anesthetic or sedative before and during surgeries or other procedures.

Contraindications of dexmedetomidine 

It is forbidden to use the drug without consulting a specialist doctor in the following cases:

Hypersensitivity to dexmedetomidine or to any of the other ingredients of the product.

Precautions before using dexmedetomidine

Use with caution under the supervision of a doctor in the following cases:

Pregnancy and breastfeeding period.

cardiovascular diseases,

diabetes.

Liver malfunction.

the elderly.

The use of this drug may cause slowing of the heart rate, hypotension and stoppage of the sinoatrial node, so it is preferable to give an initial dose and then slowly increase the dose.

Dosage of dexmedetomidine

An initial dose of 1 µg/kg over 10 minutes is given, followed by 0.2-0.7 µg/kg/hour, the rate being controlled based on the level of anesthesia.

DEXMEDETOMIDINE 200 mcg/2 ml (Jiangsu Hengrui) Solution for Injection Alternatives