DESFLURANE (SHANGHAI HENGRUI) 100% Liquid for inhalation

What is DESFLURANE (SHANGHAI HENGRUI) 100%

DESFLURANE (SHANGHAI HENGRUI) 100% is a volatile anesthetic agent utilized in general anesthesia for surgical procedures. Desflurane is a clear, colorless liquid that is administered via inhalation. The agent works primarily by depressing the central nervous system, leading to loss of consciousness and sensation. Its formulation allows for rapid induction and emergence from anesthesia, making it particularly suitable for outpatient surgeries.

The pharmacokinetic profile of desflurane is defined by its low blood-gas partition coefficient, which facilitates swift onset and offset of action. This characteristic enables quick recovery times, an important consideration in modern anesthetic practice. Desflurane has minimal metabolic degradation, thus limiting the production of potentially harmful metabolites. Its stability at room temperature also ensures ease of storage and handling.

Desflurane is frequently used in various surgical settings, including orthopedic, gynecological, and general surgical procedures. The anesthetic can be combined with nitrous oxide and opioids to enhance analgesia. Its rapid elimination from the body, primarily via exhalation, contributes to its appeal among anesthesiologists. Furthermore, desflurane does not accumulate in body fat, which allows for quick recovery of patients.

In addition to its clinical applications, desfluranes favorable pharmacological properties support its role in minimizing postoperative complications. Studies have indicated that patients receiving desflurane often experience reduced nausea and vomiting after surgery compared to those receiving other anesthetic agents. Moreover, desfluranes versatility allows it to be titrated based on real-time patient feedback during procedures.

The rapid recovery profile associated with desflurane is critical for outpatient procedures, where quick discharge is necessary. Additionally, the agent has been shown to facilitate shorter recovery times, enabling patients to return to their daily activities sooner. Overall, desflurane represents a valuable tool in the anesthetic arsenal, contributing to the safety and efficiency of surgical care.

As with any anesthetic, careful consideration must be given to patient selection and monitoring during the use of desflurane. The anesthesiologist must evaluate the patients medical history and current medications to identify potential contraindications. Pre-operative assessments are crucial to ensure optimal outcomes and minimize risks associated with anesthesia.

How to use DESFLURANE (SHANGHAI HENGRUI) 100%

• Preparation: Before administering desflurane, ensure that the anesthesia machine is functioning correctly and calibrated to deliver the appropriate concentrations of the anesthetic. Perform routine checks for leaks and ensure that all connections are secure.
• Induction: Begin with a low concentration of desflurane, typically around 3% to 6%, to induce anesthesia. Titrate the concentration based on the patient’s response and the requirements of the surgical procedure.
• Monitoring: Continuous monitoring of the patient’s vital signs is essential during the procedure. This includes heart rate, blood pressure, and oxygen saturation levels. Adjust the flow of desflurane as needed based on real-time monitoring data.
• Maintenance: Maintain desflurane delivery throughout the procedure to ensure adequate anesthesia. Adjust the concentration based on the surgical stimuli and the depth of anesthesia required.
• Emergence: Upon completion of the surgical procedure, cease administration of desflurane. Allow the patient to breathe spontaneously or provide supplemental oxygen to facilitate recovery.
• Post-operative Care: Monitor the patient during the recovery phase for any signs of complications or adverse reactions to desflurane.
• Patient Education: Inform patients about what to expect during and after anesthesia with desflurane. Discuss potential side effects and recovery processes to prepare them for their discharge.

Mode of Action DESFLURANE (SHANGHAI HENGRUI) 100%

The primary mechanism of action of desflurane involves the modulation of neurotransmission in the central nervous system. It enhances inhibitory neurotransmission while decreasing excitatory pathways, leading to a state of unconsciousness. Desflurane interacts with gamma-aminobutyric acid (GABA) receptors, promoting sedation and analgesia.

Additionally, desfluranes low solubility in blood allows for rapid equilibrium between the lungs and the bloodstream. This property facilitates quick delivery of the anesthetic to the brain, resulting in fast induction of anesthesia. Upon discontinuation, desflurane is eliminated swiftly through respiration, allowing patients to regain consciousness rapidly.

Moreover, desflurane is highly titratable, giving anesthesiologists the ability to adjust the depth of anesthesia based on the surgical requirements and patient responsiveness. The flexibility in dosing is crucial for managing the unique needs of each patient and optimizing surgical conditions.

Desfluranes pharmacodynamics support its safe and effective use in a variety of surgical procedures. Its properties enable rapid adjustments to anesthesia levels, which is beneficial in responding to changes in surgical stimuli or patient condition. Overall, desfluranes action provides anesthesiologists with the control necessary to ensure patient safety and comfort during surgical interventions.

DESFLURANE (SHANGHAI HENGRUI) 100% Interactions DESFLURANE (SHANGHAI HENGRUI) 100%

• Drug Interactions: Desflurane may interact with other anesthetic agents and medications, potentially leading to increased effects or adverse reactions. Careful consideration should be given to the use of additional agents during anesthesia.
• Coexisting Medical Conditions: Patients with respiratory disorders may experience altered responses to desflurane. A thorough assessment of lung function should be conducted prior to administration.
• Medications: The concurrent use of sedatives or muscle relaxants can potentiate the effects of desflurane, necessitating adjustments in dosages to ensure safety.
• Cardiovascular Monitoring: Desflurane may cause fluctuations in heart rate and blood pressure, which should be monitored, especially in patients with cardiovascular disease.
• Neurological Considerations: Patients with a history of seizures or neurological disorders may require special consideration when using desflurane due to its effects on the central nervous system.
• Interactions with Herbal Supplements: Patients should inform their healthcare provider about the use of herbal supplements, as some may interact with desflurane and alter its effects.

Dosage of DESFLURANE (SHANGHAI HENGRUI) 100%

The dosing regimen for desflurane is tailored to individual patient factors, including age, weight, and overall health status. The initial concentration for induction typically ranges from 3% to 6% in a nitrous oxide or oxygen mixture. For maintenance, concentrations may vary from 1% to 6%, based on the required depth of anesthesia and the patient’s physiological responses.

It is essential to monitor the patient’s reactions and adjust dosages accordingly during the surgical procedure. In pediatric patients, the dosages may differ due to variations in metabolism, necessitating careful calculation and adjustment. Regular reassessment of anesthetic depth ensures that adequate levels are maintained while minimizing potential side effects.

Desflurane should be titrated based on clinical observations and equipment readings to ensure optimal safety and efficacy during anesthesia. Anesthesia providers must remain vigilant and responsive to the patients needs throughout the procedure to ensure a safe and effective anesthetic experience.

Possible side effects of DESFLURANE (SHANGHAI HENGRUI) 100%

• Common Side Effects: Some patients may experience transient hypotension, respiratory depression, and postoperative nausea. These effects are generally mild and resolve on their own.
• Cardiovascular Effects: Fluctuations in heart rate and blood pressure can occur, particularly during the induction and emergence phases of anesthesia with desflurane.
• Respiratory Effects: Patients may experience irritation of the airway, coughing, or increased secretions following desflurane administration.
• Neurological Concerns: Rarely, desflurane has been associated with postoperative cognitive dysfunction, particularly in older patients.
• Allergic Reactions: Although extremely rare, some individuals may experience allergic reactions, such as anaphylaxis, requiring immediate medical attention.
• Long-term Effects: Ongoing studies are evaluating potential long-term effects of desflurane use, particularly in vulnerable populations.

DESFLURANE (SHANGHAI HENGRUI) 100% Contraindications DESFLURANE (SHANGHAI HENGRUI) 100%

Information not available.

Storage of DESFLURANE (SHANGHAI HENGRUI) 100%

Desflurane should be stored in a cool, dry place, away from direct sunlight and heat sources to maintain its stability. The ideal storage temperature is typically between 15°C and 30°C (59°F to 86°F). Ensure that the storage area is secure and that access is restricted to authorized personnel only.

Keep desflurane in its original container, tightly closed, to prevent contamination and degradation. The product should not be transferred to other containers as this may compromise its integrity. Regular checks should be conducted to ensure that the storage conditions remain optimal and that the medication has not expired.

Additionally, it is crucial to follow local regulations regarding the disposal of unused or expired desflurane to minimize environmental impact. Proper disposal procedures should be implemented to prevent accidental exposure or environmental contamination. Health care facilities must adhere to all relevant guidelines and protocols for the handling and storage of anesthetic agents.